ABSTRACT
BACKGROUND: It is still unclear how well the established attention deficit-hyperactive disorder (ADHD)-specific rating scales can differentiate between ADHD symptoms and symptoms of other mental disorders. METHODS: A total of 274 patients with suspected adult ADHD were extensively examined clinically and guideline-conform in an ADHD outpatient clinic. In 190 patients the diagnosis of ADHD could be made with certainty. The patients were also subsequently assessed according to the DSM IV criteria by self-rating scales on current (ADHS-SB, ASRS, CAARS) and retrospective (WURS-K) complaints. A binary logistic regression analysis was performed in order to extract from the questionnaires, which could best distinguish the diagnosis of ADHD from other mental disorders. RESULTS: The results showed that two self-rating scales (WURS-K and ADHS-SB) were sufficient to correctly diagnose ADHD in 83% of the patients examined with a sensitivity of 94% and specificity of 56%. CONCLUSION: The ADHD-specific self-rating scales are additionally useful for the diagnostic differentiation between ADHD-specific and other psychiatric symptoms in the clinical practice and can improve the safety of the diagnosis.
Subject(s)
Attention Deficit Disorder with Hyperactivity , Mental Disorders , Psychiatric Status Rating Scales , Adult , Attention Deficit Disorder with Hyperactivity/complications , Diagnosis, Differential , Diagnostic and Statistical Manual of Mental Disorders , Humans , Logistic Models , Mental Disorders/complications , Psychiatric Status Rating Scales/standards , Retrospective Studies , Sensitivity and Specificity , Surveys and QuestionnairesABSTRACT
BACKGROUND AND OBJECTIVE: Psychological problems in children and parents related to children's atopic eczema (AE) may impede the success of treatment. We studied the question, if behavior-based parental education in groups (DPE) or standardized video-education (VPE) could enhance dermatological treatment effects and reduce skin-damaging behaviors in children and stress in their mothers. PATIENTS/METHODS: 47 mothers attending the university outpatient-clinic for dermatology and their AE-children (mean age 4 years) participated in the study. 18 mothers underwent the DPE (10 sessions), 15 mothers worked with VPE at home. Dermatological standard treatment (CG; N = 14) served as control for a 16-weeks-evaluation-period. RESULTS: AE-symptoms improved overall, but the effectiveness of the treatments differed significantly, improval with parent education and was best with VPE. Psychological problems of mothers were equally reduced with DPE and VPE. CONCLUSIONS: It is suggested that VPE is a cost effective and less time consuming method for supporting dermatological therapy of AE in children.
Subject(s)
Behavior Therapy , Dermatitis, Atopic/therapy , Mothers/education , Neurodermatitis/therapy , Patient Care Team , Patient Education as Topic , Adult , Child , Child, Preschool , Dermatitis, Atopic/psychology , Female , Home Nursing/psychology , Humans , Infant , Male , Mothers/psychology , Neurodermatitis/psychology , Patient Compliance , Pilot Projects , Treatment OutcomeABSTRACT
Wheat flour was extracted with phosphate-buffered saline. The biologic significance of the extracted cereal proteins was demonstrated. Basophil leukocytes were obtained from patients suffering from "baker's asthma disease." Histamine release in vitro was induced by addition of the aqueous flour extract. By means of ELISA, as well as immunoblotting technique, IgG and IgE binding to wheat flour proteins was demonstrated. Wheat-specific antibodies could be detected in sera obtained from healthy and atopic individuals. Further analysis of the cereal components by monoclonal antibodies revealed that several wheat molecules exhibit identical epitopes.
Subject(s)
Antibodies, Monoclonal/immunology , Antigens/analysis , Flour/analysis , Immunoglobulin E/immunology , Immunoglobulin G/immunology , Plant Proteins/immunology , Allergens/analysis , Animals , Edible Grain/analysis , Histamine Release , Humans , Mice , Plant Extracts/immunology , Plant Proteins/analysisABSTRACT
Malignant fibrous histiocytomas of the storiform pleomorphic type were found in the lower legs of two patients, 79 and 42 years of age. In the first, dermatofibrosarcoma protuberans, in the second, squamous cell carcinoma, had to be discussed. In the first patient, the tumor arose in the area of a preexisting paresis of the superficial peroneal nerve; the second patient developed the tumor in fistulous osteomyelitis existing since childhood.
