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Exp Biol Med (Maywood)
; 245(13): 1122-1129, 2020 07.
Article
in English
| MEDLINE
| ID: mdl-32389029
ABSTRACT
IMPACT STATEMENT: WW domain-containing oxidoreductase encoded by the WWOX gene is a transcription regulator and a key player in a number of cellular and biological processes such as tumor suppression, cell proliferation, apoptosis induction, steroid metabolism, and central nervous system development. This review provides a comprehensive summary of currently known roles and discusses the importance of WWOX gene for CNS development and functioning.