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1.
Isolation and characterization of two 16-membered lactones: 20-deoxorosaramicin and 20-deoxo-12,13-desepoxy-12,13-dehydrorosaramicin aglycones, from a mutant strain of Micromonospora rosaria.
Vaughan, R W; Lotvin, J; Puar, M S; Patel, M; Kershner, A; Kalyanpur, M G; Marquez, J; Waitz, J A.
J Antibiot (Tokyo) ; 35(2): 251-3, 1982 Feb.
Article in English | MEDLINE | ID: mdl-7076570

Subject(s)
Leucomycins/isolation & purification , Micromonospora/analysis , Tylosin/analogs & derivatives , Leucomycins/biosynthesis , Magnetic Resonance Spectroscopy , Mass Spectrometry , Micromonospora/genetics , Mutation
2.
Biosynthetic pathway leading to gentamicin C2b.
Lee, B K; Nagabhushan, T L; Condon, R G; Shimonaski, G; Kalyanpur, M G; Patel, M; Waitz, J A.
Antimicrob Agents Chemother ; 16(5): 589-91, 1979 Nov.
Article in English | MEDLINE | ID: mdl-525999

ABSTRACT

Incubation of Micromonospora purpurea SC 1210 (NRRL 5467) with L-[methyl-14C]methionine yielded [methyl-14C]gentamicin A and methyl-14C-labeled antibiotic JI-20A in a molar radioactivity ratio of 9:2. We did not isolate methyl-14C-labeled gentamicin X2, which was expected as an intermediate based on the biosynthetic pathways proposed by others. Addition of methyl-14C-labeled antibiotic JI-20A to M. purpurea SC 1124 (NRRL 8102) yielded [methyl-14C]-gentamicin C1a and [methyl-14C]gentamicin C2b in variable molar radioactivity ratios. These data do not support the biosynthetic pathway leading to gentamicin C2b proposed by Testa and Tilley.


Subject(s)
Gentamicins/biosynthesis , Micromonospora/metabolism , Fermentation
3.
Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine.
Cole, F E; Kalyanpur, M G; Stevens, C M.
Biochemistry ; 12(17): 3346-50, 1973 Aug 14.
Article in English | MEDLINE | ID: mdl-4270046

Subject(s)
Leucine/biosynthesis , Malates/metabolism , Neurospora/metabolism , Acetates/metabolism , Anhydrides/biosynthesis , Carbon Isotopes , Chemical Phenomena , Chemistry , Citrates , Isocitrates , Isomerism , Malates/biosynthesis , Maleates/biosynthesis , Models, Structural , Mutation , Neurospora crassa/metabolism , Propane/biosynthesis , Structure-Activity Relationship , Tritium , Valine/metabolism , X-Ray Diffraction
4.
Use of Torulopsis utilis and invert sugar in Streptomycin fermentation.
Pilagaokar, A K; Borkar, P; Chiddarwar, P P; Kalyanpur, M G.
Hindustan Antibiot Bull ; 12(2): 81-5, 1970.
Article in English | MEDLINE | ID: mdl-5464095

Subject(s)
Mitosporic Fungi , Streptomycin/biosynthesis , Fermentation , Fructose , Glucose , Streptomyces/metabolism
5.
The absolute configuration of homocitric acid (2-hydroxy-1,2,4-butanetricarboxylic acid), an intermediate in lysine biosynthesis.
Thomas, U; Kalyanpur, M G; Stevens, C M.
Biochemistry ; 5(8): 2513-6, 1966 Aug.
Article in English | MEDLINE | ID: mdl-5968558

Subject(s)
Citrates , Lysine/biosynthesis , Chemical Phenomena , Chemistry, Organic , Chemistry, Physical , Infrared Rays , Mutation , Organic Chemistry Phenomena , Quinic Acid , Saccharomyces , Spectrophotometry
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