Quetiapine versus Haloperidol in Controlling Conversion Disorder Symptoms; a Randomized Clinical Trial.

INTRODUCTION: About 5% of visits to emergency departments are made up of conversion disorder cases. This study was designed with the aim of comparing the effectiveness of quetiapine and haloperidol in controlling conversion disorder symptoms. METHODS: The present single-blind clinical trial has been performed on patients with conversion disorder (based on the DSM-IV definition) presenting to emergency department of 9-Day Hospital, Torbat Heydariyeh, Iran, from January 2017 until May 2018. RESULTS: 73 patients were allocated to haloperidol and 71 to quetiapine group. Mean age of these patients was 32.03 ± 12.80 years (62.50% female). Two groups were similar regarding the baseline characteristics. Within 30 minutes, 90.41% of haloperidol cases and 91.55% of quetiapine cases were relieved (p=0.812). The most common side effects after 30 minutes were extrapyramidal symptoms (9.59%) in the haloperidol group and fatigue and sleepiness (7.04%) in the quetiapine group. Extrapyramidal symptoms was significantly higher than the quetiapine group (p=0.013). CONCLUSION: The results of the present study showed that although quetiapine and haloperidol have a similar effect in relieving the patients from conversion disorder symptoms, the prevalence of extrapyramidal symptoms is significantly lower in the group under treatment with quetiapine. Therefore, it seems that quetiapine is a safer drug compared to haloperidol.

Nonlinear analysis of postural sway in subjects with below knee amputation during opened and closed eye conditions.

OBJECTIVE: The aim of this study was to compare the structure of postural sway in healthy people and amputees with SACH foot (solid ankle cushion heel) and single axis foot during standing. METHODS: Twenty healthy, 10 amputees with single axis foot, and 10 amputees with SACH foot participated in this study. The structure of postural sway of the subjects was evaluated using approximate entropy (ApEn). RESULTS: People with SACH foot prosthesis exhibit increased regularity in postural sway compared to healthy people and people with single axis foot. CONCLUSION: Amputees who used single axis prosthesis achieved appropriate adaptation to their prosthesis device.

Evaluation of the efficiency of cervical orthoses on cervical fracture: A review of literature.

BACKGROUND: Various methods have been used to stabilize the vertebra in cervical fractures, including the use of various orthoses and surgery. However, it is not cleared which type of orthosis is more suitable for the subjects with cervical fractures to best immobilize the vertebra and to decrease the associated side effects. Therefore, the aim of this study was to evaluate the efficiency of various orthoses based on the available literature. MATERIALS AND METHODS: A search was done in some databases include PubMed, ISI Web of Knowledge, EBSCO, Embasco, and Google Scholar. The search was done with some key words such as: Cervical spine injuries; odontoid fractures; hangman's fractures; axis fracture; axis, atlas, cervical fractures; trauma; neck fracture; neck injury in combination with cervical orthoses. The quality of the studies was evaluated by use of Downs and Black assessment and Assessment of Multiple Systematic Reviews (AMSTAR) for original research and review articles, respectively. RESULTS: Based on the aforementioned key words, 25 papers were selected. The quality of the studies varies 10-24. Most of the studies were on the use of the halo vest orthosis, its side effects and also on complications associated with various orthoses. DISCUSSION: Halo orthoses provide a high degree of restriction and immobilization; however, there are some side effects associated with this orthosis, including swallowing, pin loosening, and infection. It should be emphasized that other types of orthoses fewer complications, with reasonable outputs on motion restrictions.

Balance and gait performance of scoliotic subjects: A review of the literature.

INTRODUCTION: Scoliosis is one of the common spinal deformities and considered as lateral curvature of the spine. Scoliosis lead to changes in the synergy between body segments, spinal anatomy, left-right trunk symmetry and cause pathological gait pattern [1,4,5-7]. Scoliosis is a structural deformity, so it can alter center of mass (COM) position and weight distribution on lower limbs. This suggests that scoliotic patients show the poorer stability rather aged match normal group. It was controversial that scoliosis influences the balance and gait performances, and also the effects of brace on these parameters. Therefore, it was aimed to evaluate the available literatures on balance and gait of scoliotic subjects. MATERIALS AND METHODS: We conducted a search via PubMed, Google scholar and ISI web of knowledge to identify studies on scoliosis field and the effect of this deformity on kinetic and kinematic parameters as well as the influence of bracing on mentioned parameters. Some key words such as kinetic, kinematic, gait, stability, and walking were used in combination with scoliosis. The publication dates of the full-length articles were between 1998 and 2014. Down and Black tool was used to evaluate the quality of the articles. RESULTS: Our multiple Medline searches led to the find out 54 papers that 26 of which were relevant based on title and abstract. Based on their references, we retrieved 6 more articles. We ultimately included 31 articles in this literature review. The number of studies regarding the influence of brace on kinetic and kinematic parameters in scoliotic subject was small. Based on the results of various studies, there is no correlation between gait pathology and scoliotic curve direction, no difference between stability of scoliotic and normal subjects and no difference between range of motions of lower limb joints in scoliotic subjects while walking with and without orthosis. CONCLUSION: There was a not sufficient robust evidence to judge about the influence of scoliosis deformity on kinetic and kinematic parameters. However, it should be emphasized that use of orthosis may influence the symmetry of gait and improve standing stability in adult with idiopathic scoliosis.

A comparison of linear and nonlinear stability parameters in different clinical forms of multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) is one of the neurological diseases that affect the ability of subjects to stand and walk. The stability of MS subjects has been evaluated in various studies, mostly based on linear approach. Based on this approach it is controversial weather stability of MS subjects differ from normal or not. Therefore, the aim of this study was to evaluate stability in three groups of MS subjects (spastic, ataxic and ataxic-spastic) using both linear and non-linear approaches. METHOD: Seventeen healthy and 36 subjects with MS participated in this study. The MS group presenting with spastic, ataxic and ataxic-spastic (each group consisted of 12 subjects) participated in the study. The stability of the subjects was evaluated using Kistler force plate. The difference between stability of the subjects was evaluated using the Multi Analysis of Variance and significant value was set at P < 0.05. RESULT: There was a significant difference in the mean value of Approximate Entropy (ApEn) in anterior-posterior direction between normal (0.66 ± 0.13) and ataxic (0.85 ± 0.12) and ataxic-spastic (0.90 ± 0.12) subjects (P < 0.05) and no difference between normal and spastic groups (0.76 ± 0.13). The results of both linear and nonlinear approaches confirmed that both ataxic and ataxic-spastic subjects had more instability than normal subjects. Although, the mean values of stability parameters increased in spastic compared to normal, the difference was not statistically significant. CONCLUSION: Subjects with ataxic and ataxic-spastic MS disorder had difficulty in controlling their stability during quiet standing. The results of this study also confirmed that spasticity of muscles surrounding the hip and knee joints did not influence standing stability in patients with spastic MS.

Influential factors in stability of lower-limb amputees.

OBJECTIVE: Lower-limb amputation is mainly a result of trauma, vascular disease, diabetes, or congenital disorders. Persons with amputation lose their ability to stand and walk on the basis of the level of amputation. Contribution of level of amputation, type of amputation, or cause of amputation to balance impairment has not been clearly defined. Furthermore, it is controversial how much the mentioned parameters influence standing stability. Therefore, the aim of this review article was to find the relationship between the abovementioned factors and balance impairment in the available literature. It was also aimed to find the possibility of improving standing stability by the use of different prosthesis components. DESIGN: An electronic search was done via the PubMed, EMBASE, and ISI Web of Knowledge databases from 1960 to 2012. Quality of the articles was assessed using the Downs and Black tool. RESULTS: On the basis of the used key words, 100 articles were found, of which 20 articles were selected in accordance with the selection criteria. The scores of reporting, external validity, internal validity (bias), and internal validity (confounding) varied between 4-9, 1-3, 3-5, and 2-6, respectively. CONCLUSIONS: The literature review confirmed that standing stability of amputees depends on level of amputation, type of amputation, and cause of amputation. Moreover, prosthetic characteristics such as prosthetic ankle stiffness have influences on dynamic stability, whereas torsional adaptor does not have any positive influence on stability during level walking and on turning stability. Therefore, it can be concluded that the stability of a person with amputation can be improved by the use of appropriate prosthesis components.