ABSTRACT
A 12-year old girl presented with general weakness and weight loss, a localised cervical lymph node enlargement and cutaneous lesions compatible with lymphomatoid papulosis (LyP). Biopsies from lymph node and skin revealed a histological diagnosis of nodal large cell ALK-1- anaplastic lymphoma (ALCL) with a synchronous CD30+ cutaneous lymphoproliferation consistent with lymphomatoid papulosis (LyP). The girl was treated with mistletoe (MT) as monotherapy. Within 1 week after initiation of MT-treatment the skin lesions and lymph node enlargement improved. Under continuing MT-therapy 30 months after diagnosis the patient is still in complete remission. It is not possible to know whether this was a rare case of spontaneous remission of the nodal and skin-manifestations of this CD30+ T-cell lymphoproliferation or whether the observed effect was a specific therapeutic response to MT-treatment.
Subject(s)
Activin Receptors, Type II/analysis , Lymphoma, Large-Cell, Anaplastic/drug therapy , Lymphomatoid Papulosis/drug therapy , Mistletoe , Phytotherapy , Plant Extracts/therapeutic use , Remission Induction , Skin Neoplasms/drug therapy , Child , Female , Follow-Up Studies , Humans , Lymph Nodes/pathology , Lymphoma, Large-Cell, Anaplastic/diagnosis , Skin Neoplasms/diagnosisSubject(s)
DNA Mutational Analysis , Thyroid Hormone Receptors beta/genetics , Alleles , Chromosome Aberrations , Chromosomes, Human, Pair 3/genetics , Codon/genetics , Exons/genetics , Female , Follow-Up Studies , Genes, Dominant/genetics , Genetic Carrier Screening , Humans , Infant , Infant, Newborn , Thyroid Function Tests , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/bloodABSTRACT
We present a 9-year-old girl who developed acute muscular weakness of proximal muscles of the upper and lower limbs. Investigations revealed a common acute lymphoblastic leukemia. The neuromuscular symptoms are classified as a paraneoplastic neurological syndrome (PNS). Under chemotherapy according to ALL-BFM-2000 protocol symptoms resolved within 4 weeks. This case presents a rare manifestation of acute lymphoblastic manifestation.
Subject(s)
Neuromuscular Diseases/diagnosis , Paraneoplastic Syndromes/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Diagnosis, Differential , Female , Humans , Muscle Weakness/diagnosis , Muscle Weakness/drug therapy , Neuromuscular Diseases/drug therapy , Paraneoplastic Syndromes/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapyABSTRACT
A hitherto healthy 7-year-old girl underwent antiproliferative and antibiotic treatment owing to the diagnosis of T-cell lymphoma and concomitant bacterial infection. She developed an encephalopathic crisis associated with metabolic acidosis, hyponatraemia and severe hyperhomocysteinaemia and 5-oxoprolinuria. Laboratory tests normalized completely after recovery. Primary defects in glutathione metabolism could be excluded.
Subject(s)
Anti-Infective Agents/adverse effects , Hyperhomocysteinemia/etiology , Lymphoma, T-Cell/drug therapy , Pyrrolidonecarboxylic Acid/urine , Acidosis , Anions , Antineoplastic Agents/adverse effects , Child , Female , Glutathione/metabolism , Homocysteine/chemistry , Humans , Phenytoin/chemistry , Polymorphism, Genetic , Time FactorsABSTRACT
The effects of the dopaminergic agonists (L-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of the animals. This method was found to be a reliable procedure to quickly screen compounds with specific sites of action in the brain for their effects on the voluntary intake of nicotine or perhaps other substances of abuse as well. L-dopa, pergolide and haloperidol did not affect the intake of nicotine, whereas tacrine increased it slightly and clozapine and mecamylamine markedly. These results indicate that blockade of nicotinic and dopaminergic D4 receptors partially reduce the desired effect of nicotine by forcing the animals to consume more of this substance.
