ABSTRACT
The potency of Ondansetron (Zofran, Glaxo), a highly specific 5HT3 antagonist in preventing the very unfavorable complication during introducing anesthesia, i.e. a Bezold-Jarisch reflex-like reaction, was studied in a clinical trial. A total of 20 patients (12 males and 8 females aged 19-65 years) admitted for clinical surgical treatment participated in the trial. Zofran (8 mg in 500 ml Ringer solution) was injected intravenously one hour before intubation at a flow rate of 8 ml. min-1. Systolic and diastolic blood pressure, central venous pressure, breathing frequency and minute ventilation, pCO2 and pO2 in venous blood, electrocardiogram monitoring (ECG) and several common features such as spontaneous muscle activity, palpebral reflexes, skin and mucose surfaces were continuously observed. Visual, auscultatory and X-ray control of the lungs was effected. It was found that blockade of 5HT3 receptors prevented the appearance of Bezold-Jarisch reflex-like reaction. The drug could successfully be used in anesthesiological practice.
Subject(s)
Ondansetron/therapeutic use , Premedication , Adult , Aged , Anesthesia/adverse effects , Bradycardia/prevention & control , Female , Hemodynamics/drug effects , Humans , Hypertension/prevention & control , Male , Middle Aged , Ondansetron/adverse effects , Reflex/drug effects , Vomiting/prevention & controlABSTRACT
Effects of three uvs mutations were studied on spontaneous and nitrosomethyl-induced intragenic mitotic segregation in the methA region of the chromosome II in Aspergillus diploids homozygous for uvs and heteroallelic for methA mutation. The reversion frequencies of methA alleles in parent haploid strains were also determined. All the mutations increased the frequency of spontaneous and decreased that of induced intragenic mitotic recombination. The frequency of spontaneous reversions was decreased in uvs haploids. The interaction between repair, recombination and mutagenesis processes in Aspergillus nidulans is discussed.
