[Enterotoxic properties of salmonellae and their neurotoxins]. / Enterotoksicheskie svoistva sal'monell i kh neirotoksinov.

Most of live S. typhimurium cultures are capable of intraintestinal proliferation and possess enterotoxic activity. The capacity of S. typhimurium strains for producing enterotoxins is not connected with their origin. The parenteral immunization of rabbits with corpuscular vaccines prepared from S. typhimurium induced changes in the sensitivity of different sections of the small intestine of the animals to the enterotoxic action of live homologous cultures. Neurotoxin isolated from S. typhi was found to possess enterotoxic activity.

[Biological characteristics of Salmonella typhimurium obtained from different sources 1975-1980]. / Biologicheskie osobennosti Salmonella typhimurium, poluchennykh iz raznykh istochnikov v 1975-1980 gg.

Distinct differences in a number of biological properties between S. typhimurium hospital strains and cultures of animal origin have been revealed. During 1975-1980 changes in the fermentation of lysine were observed in hospital strains and the retarded fermentation of sorbitol was revealed in strains of animal origin. S. typhimurium 1R, a new highly virulent biovariant resistant to antibiotics, and enzymatic varieties of biovar 11S were isolated. The nonstability of enzymatic differences between hospital strains and cultures of animal origin necessitates their constant observation in order to differentiate these cultures for the purpose of epidemic analysis. Complete correlation between the properties of cultures circulating on a limited territory and the character of morbidity in Salmonella infection demonstrates the epidemiological importance of the intraspecific differentiation tests under study.

[Study of the enterotoxic action of the neurotoxin of the Sonne dysentery microbe in a rabbit small intestine loop model]. / Izuchenie énterotoksicheskogo deistviia neirotoksina dizenteriinogo mikroba Zonne na modeli izolirovannoi petli tonkogo kishechnika krolika.

The enterotoxic action of neurotoxin from Sonne dysentery microbes (obtained by the method of Mesrobeanu et al.), and also of the culture autolysates and homologous Boiven's endotoxin was studied on a model of the isolated loop of the rabbit small intestine. Neurotoxin preparations obtained from virulent strains as well as autolysates of these cultures possessed enterotoxic activity, whereas purifed endotoxin preparations in doses of 1--10 mg failed to cause any dilatation of the isolated intestinal segment. A significant individual rabbit sensitivity to the enterotoxic action of the neurotoxin preparation was revealed. Lyophilization of neurotoxin preparation did not influence its enterotoxicity. However dialysis against distilled water and boiling of the neurotoxin preparations led to the loss of enterotoxic activity.

[Enterotoxic activity of live cultures of Sonne dysentery microbes and formation of enterotoxin in vivo]. / Enterotoksicheskaia aktivnost' zhivykh kul'tur dizenteriinogo mikroba Zonne i obrazovanie énterotoksina in vivo.

The great majority of virulent Sonne dysentery bacillus cultures caused an accumulation of the fluid in the lumen of the isolated segment of the rabbit small intestine containing a great amount of mucus and sometimes of the blood as well; the segment mucosa was hyperemic and had punctate hemorrhages. Avirulent microbial cultures as a rule caused no exudation in the intestinal lumen. Sterile and concentrated contents of the intestinal loops responding to the centrated contents of the intestinal loops responding to the administration of the virulent culture of Sonne bacillus or a toxigenic strain of Grigoriev-Shiga dysentery bacillus caused a positive response in other rabbits. The character of the exudate and the changes in the mucosa failed to differ from such following the administration of live cultures.