Subject(s)
Acetabulum/chemistry , Durapatite/chemistry , Polyethylene/chemistry , Prostheses and Implants , Animals , Biocompatible Materials/adverse effects , Durapatite/adverse effects , Erythrocyte Count , Hip Joint/surgery , Humans , Knee Joint/surgery , Leukocyte Count , Mutagenesis , Polyethylene/adverse effects , Prostheses and Implants/adverse effects , RatsSubject(s)
Boron Compounds/chemistry , Materials Testing , Polyethylene/chemistry , Polymers/chemistry , Radiation Protection , Sulfones/chemistry , Tungsten/chemistry , Animals , Boron Compounds/pharmacology , Humans , Mice , Polyethylene/pharmacology , Polymers/pharmacology , Sulfones/pharmacology , Tungsten/pharmacologyABSTRACT
Self-hardening material for metal plastic permanent dentures, has been developed by the Central Research Institute of Dentistry for the first time in Russia. Its physicomechanical properties are described and the results of toxicological trials are presented. The new material is superior in wear resistance to foreign analogs Kulzer Dentacolor and ESPE Visio-Gem. Toxicological studies demonstrated the biological inertness of the material during long contact with the internal media of human organism and the absence of toxic, sensitizing, and mutagenic action.
Subject(s)
Dental Casting Technique , Denture, Partial, Fixed , Polymers/chemistry , Acrylic Resins/chemistry , Animals , Composite Resins/chemistry , Dental Porcelain/chemistry , Denture, Partial, Fixed/statistics & numerical data , Humans , Implants, Experimental/adverse effects , Implants, Experimental/statistics & numerical data , Male , Materials Testing/statistics & numerical data , Mechanics , Methacrylates/chemistry , Polymers/toxicity , Rats , Resin Cements/chemistry , Silanes/chemistry , Time FactorsABSTRACT
Toxic characteristics of Superpal, a dental palladium-based alloy for cermet dentures, were studied in a chronic experiment on 20 rats to which it was subcutaneously implanted. Analysis of histological findings, blood biochemistry, mast cell degranulation test, summarization of subthreshold pulses, and the micronucleus test showed that Superpal alloy is biologically inert, nontoxic, exerts no sensitizing and mutagenic effects, and may be used for making cement dentures.
Subject(s)
Biocompatible Materials/toxicity , Dentures , Gold Alloys/toxicity , Metal Ceramic Alloys/toxicity , Palladium/toxicity , Analysis of Variance , Animals , Cell Degranulation/drug effects , Male , Mast Cells/drug effects , Mast Cells/physiology , Materials Testing/methods , Materials Testing/statistics & numerical data , Micronucleus Tests , Prostheses and Implants/adverse effects , Rats , Time FactorsABSTRACT
Several modifications of copper amalgams were examined. The findings evidence that of the amalgam constituents only copper passes into saliva, nutrient media, and animal body tissues and accumulates there. The findings of sanitary chemical and toxicologic studies helped select a hygienically optimal copper amalgam sample exerting no detrimental effects on the body.