[Carcinoma of the vulva in women: clinical and morphopathological problems]. / Rak sromu u kobiet--problemy kliniczne i patomorfologiczne.

Surgery is the mainstay of the treatment of vulvar cancer. Radical vulvectomy together with some form of lymphadenectomy is the usual treatment today, but the desire to minimize morbidity have led to a selective decrease in the extent of the surgery in recent years. We recommended retroperitoneal pelvic lymphadenectomy be used only if the inguinal nodes were positive. The approach has become widely accepted. Improvements in perioperative care and anesthetic techniques have allowed the surgical approach to be used in most patients, even in older women seen so commonly with this cancer.

Risk of atherosclerosis in women six years after uterine leiomyoma surgery as compared with healthy women.

44 women at the age between 40 and 60, who underwent uterine leiomyoma surgery six years previously and 45 healthy women were examined for total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides (TG) and 17 beta-estradiol (E2). The value of the atherogenic coefficient [sequence: see text] and [sequence: see text] were determined. The clinical condition of the women was also evaluated. It was shown that independently on the extent of surgery, significantly (p < 0.01 and p < 0.001) higher values of LDL-C and lower values (p < 0.05) of atherogenic coefficients of [sequence: see text] were recorded, which is evidence of risk atherosclerosis and coronary heart disease (CHD) in all groups of women. A greater intensity of atherosclerotic changes in women with bilateral oophorectomy (group B'beta) may be connected both with older age and a higher body weight inducing these processes and is evidence of pathogenetic disorders caused by laparotomy. We confirmed that oophorectomy in women with leiomyoma during the perimenopausal period does not result in atherosclerosis and CHD risk when preserving the ovaries during laparotomy.

Some parameters of lipid metabolism in women 6 years after surgery on account of uterine leiomyoma.

The examinations were carried out in 44 women (age between 40 and 60 years) six years after surgery on account of a uterine leiomyoma. The total cholesterol (TC) level, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides (TG) and 17 beta-estradiol (E2) as well as the values of the atherogenic coefficient HDL-C/TC- and HDL-C/LDL-C were assessed. The subjects were divided into 3 age groups as well as groups with regard to the extent of surgery. In younger women with partial oophorectomy no changes of the lipid metabolism were found. In older women, however, with hysterectomy and oophorectomy, the risk of atherosclerosis reached the threshold of compensatory abilities and was marked by a decrease of mean values of HDL-C/LDL-C (p < 0.05), with an increase of HDL-C/TC- (p < 0.001).

[Evaluation of the influence of certain epidemiologic factors on development of uterine myomas]. / Ocena wplywu niektórych czynników epidemiologicznych na powstawanie miesniaków macicy.

Age of menarche, fertility, number of labours, body weight, physical and mental activity, and incidence of stress in everyday life were evaluated in 72 women with uterine myomas, aged 34-54 years. The control group consisted of 45 healthy women at similar age. It was demonstrated that overweight (p < 0.05, p < 0.001 in most groups studied) in combination with low physical activity and higher mental (stress producing) was a risk factor in the aetiology and pathogenesis of this disease. Fertility and number of labours as well as the age of menarche were unchanged (p > 0.05).

Postoperative serum levels of some fat metabolism parameters in women with uterine leiomyoma, depending on the extent of surgery.

Serum levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides (TG), and 17 beta-estradiol (E2) as well as LDL1-cholesterol (LDL1-C) and atherogenic coefficient HDL-C/TC and HDL-C/LDL1-C were determined in 72 patients with uterine leiomyoma and 45 healthy women aged 34-54. The extent of surgery was found to have no significant effect on fat metabolism in the early postoperative period. Because of a possible exhaustion of body compensatory potential protecting against atherosclerosis, it was found necessary to measure fat metabolism parameters during the postoperative check-ups.

Serum levels of some fat metabolism parameters in women with uterine leiomyoma.

Serum levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides (TG) and, 17 beta-estradiol (E2), as well as the values of LDL1-cholesterol (LDL1-C), HDL-C/TC, and HDL-C/LDL1-C were determined in 72 patients with uterine leiomyoma and 45 healthy women aged 34-54. The subjects were divided into three groups according to age and menstrual status (B1I-III). The patients were further subdivided into groups N and P, depending on the leiomyoma size, in order to assess the intensity of the pathogenic process. The values of cholesterol parameters (CT, HDL-C) showed a statistically significant increase in the youngest patients. The study also confirmed the opinion that hyperestrogenism could play a role in the etiopathogenesis of uterine leiomyoma.