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1.
Int J Hematol ; 119(3): 265-274, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38253960

ABSTRACT

The new Japanese diagnostic criteria for obstetrical disseminated intravascular coagulation (DIC) (tentative version) were released in June 2022. We aimed to demonstrate the differences in characteristics between women with DIC diagnosed using the new Japanese criteria and those diagnosed using the pregnancy-specific modified International Society on Thrombosis and Hemostasis DIC score, also known as the pregnancy-specific modified ISTH DIC score, which was released in 2014. In this retrospective cohort study, all participants were retrospectively diagnosed based on both criteria. Six women were diagnosed with obstetrical DIC based on both criteria (Group A). Of the 43 women diagnosed with obstetrical DIC based on the worldwide criteria, 36 were diagnosed with non-obstetrical DIC based on the new Japanese criteria (Group B). Group A had significantly lower fibrinogen levels and significantly higher prothrombin time differences and scores of underlying diseases (particularly postpartum hemorrhage with coagulopathy) and laboratory findings than Group B. Additionally, Group A had significantly higher rates of platelet concentrate (PC) transfusion therapy for obstetrical DIC and more transfusions of fresh frozen plasma and/or cryoprecipitate, red blood cells and PC than Group B. Thus, the new Japanese criteria detected more severe cases of obstetrical DIC compared with the worldwide criteria.


Subject(s)
Disseminated Intravascular Coagulation , Thrombosis , Pregnancy , Humans , Female , Retrospective Studies , Japan , Disseminated Intravascular Coagulation/diagnosis , Disseminated Intravascular Coagulation/etiology , Hemostasis
4.
Int J Gynecol Pathol ; 39(1): 79-83, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31815893

ABSTRACT

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Exploratory laparotomy was carried out to confirm the diagnosis. The frozen tissue sections of the ovarian tumor showed condensed proliferation of atypical round cells accompanied with a few small lymphocytes. The pathologists could not determine whether this tumor was a lymphoma or another malignancy (eg, dysgerminoma). Hence, they reported it to gynecologists who operated as simply a malignant tumor in order to evade misdiagnosis. On the basis of the inconclusive pathologic report, the gynecologists decided to change the planned laparotomy to total hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection. A postoperative paraffin section-based pathologic diagnosis was diffuse large B-cell lymphoma of the ovary, which basically does not require surgical treatments. Subsequently, chemotherapy for B-cell lymphoma was initiated, and no lymphoma recurrence has been reported to date. A more robust preoperative discussion between the gynecologists and the pathologists might have avoided the overtreatment.


Subject(s)
Intraoperative Care , Lymphoma, Large B-Cell, Diffuse/diagnosis , Lymphoma, Large B-Cell, Diffuse/surgery , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/surgery , Aged , Female , Frozen Sections , Humans , Hysterectomy , Lymph Node Excision , Lymphoma, Large B-Cell, Diffuse/pathology , Magnetic Resonance Imaging , Medical Overuse , Neoplasm Recurrence, Local , Ovarian Neoplasms/pathology , Pelvis/surgery , Referral and Consultation , Salpingo-oophorectomy , Treatment Outcome
5.
J Obstet Gynaecol Res ; 45(7): 1414-1417, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31012190

ABSTRACT

Differentiation of endocervical adenocarcinomas involving the uterine corpus from primary endometrial (EM) carcinomas involving the cervix is, not only clinically but also pathologically, often difficult. We report a case of gastric-type endocervical adenocarcinoma involving the corpus that could be correctly diagnosed because it was a unique endocervical adenocarcinoma subtype. A 69-year-old woman who presented with abnormal genital bleeding was diagnosed as having a uterine adenocarcinoma on pathological examination of EM biopsy. Preoperative imaging findings and a surgical specimen showed that the tumor was mainly located in the corpus and involved the cervix. We considered at first that the tumor was an EM adenocarcinoma invading into the cervix. However, results of an immunohistochemical examination indicated that it was a gastric-type mucinous adenocarcinoma derived from the endocervix. Our final pathological diagnosis was a gastric-type endocervical adenocarcinoma spreading to the uterine corpus.


Subject(s)
Adenocarcinoma, Mucinous/diagnosis , Carcinoma/diagnosis , Endometrial Neoplasms/diagnosis , Stomach Neoplasms/diagnosis , Uterine Cervical Neoplasms/diagnosis , Adenocarcinoma, Mucinous/pathology , Aged , Diagnosis, Differential , Female , Humans , Stomach Neoplasms/pathology , Uterine Cervical Neoplasms/pathology , Uterus/pathology
6.
J Neurosurg Pediatr ; 14(3): 271-8, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25014323

ABSTRACT

OBJECT: Porencephalic cyst/encephalomalacia (PC/E) is a brain lesion caused by ischemic insult or hemorrhage. The authors evaluated magnetoencephalography (MEG) spike sources (MEGSS) to localize the epileptogenic zone in children with intractable epilepsy secondary to PC/E. METHODS: The authors retrospectively studied 13 children with intractable epilepsy secondary to PC/E (5 girls and 8 boys, age range 1.8-15 years), who underwent prolonged scalp video-electroencephalography (EEG), MRI, and MEG. Interictal MEGSS locations were compared with the ictal and interictal zones as determined from scalp video-EEG. RESULTS: Magnetic resonance imaging showed PC/E in extratemporal lobes in 3 patients, within the temporal lobe in 2 patients, and in both temporal and extratemporal lobes in 8 patients. Magnetoencephalographic spike sources were asymmetrically clustered at the margin of PC/E in all 13 patients. One cluster of MEGSS was observed in 11 patients, 2 clusters in 1 patient, and 3 clusters in 1 patient. Ictal EEG discharges were lateralized and concordant with MEGSS in 8 patients (62%). Interictal EEG discharges were lateralized and concordant with MEGSS hemisphere in 9 patients (69%). Seven patients underwent lesionectomy in addition to MEGSS clusterectomy with (2 patients) and without (5 patients) intracranial video-EEG. Temporal lobectomy was performed in 1 patient and hemispherectomy in another. Eight of 9 patients achieved seizure freedom following surgery. CONCLUSIONS: Magnetoencephalography delineated the extent of the epileptogenic zone adjacent to PC/E in patients with intractable epilepsy. Complete resection of the MEGSS cluster along with PC/E can provide favorable seizure outcomes.


Subject(s)
Electroencephalography , Encephalomalacia/complications , Epilepsy/pathology , Epilepsy/surgery , Hemispherectomy , Magnetic Resonance Imaging , Magnetoencephalography , Adolescent , Child , Child, Preschool , Epilepsy/etiology , Epilepsy/physiopathology , Female , Humans , Infant , Male , Retrospective Studies , Video Recording
7.
Plant Cell Physiol ; 53(10): 1720-7, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22915573

ABSTRACT

Fructose 1,6-bisphosphate aldolase (FBA) is an enzyme involved in both glycolytic and photosynthetic reactions in photosynthetic organisms. In prokaryotes, the bidirectional reaction proceeds in the same cellular compartment, i.e. the cytoplasm. Expression of the FBA gene, fbaA, is induced through two independent pathways, stimulated by continuous light and by glucose plus pulsed light (GPL), in a cyanobactrium, Synechocystis sp. PCC 6803. Under GPL conditions, glucose can be replaced by glucose analogs that are not even metabolized in a cell. Analyses of transcripts in deletion mutants suggested that both a histidine kinase, Hik8, and a response regulator, Sll1330, played important roles as signal components in fbaA expression under GPL conditions, but not under photosynthetic conditions. Analysis of a transformant in which sll1330 expression was enhanced demonstrated that fbaA expression was induced at least partially even without glucose, but for its further induction a pulsed light stimulus was required. These results substantiated that there are two light-dependent regulatory pathways for aldolase gene expression in this cyanobacterium.


Subject(s)
Fructose-Bisphosphate Aldolase/genetics , Gene Expression Regulation, Bacterial , Glucose/metabolism , Synechocystis/genetics , Synechocystis/metabolism , Bacterial Proteins/genetics , Bacterial Proteins/metabolism , Fructose-Bisphosphate Aldolase/metabolism , Gene Regulatory Networks , Histidine Kinase , Light , Mutation , Photosynthesis/genetics , Protein Kinases/genetics , Protein Kinases/metabolism , Signal Transduction
8.
Int J Neurosci ; 116(9): 1045-53, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16861167

ABSTRACT

The aim of the study was to investigate the modulation of the soleus H-reflex during static and dynamic imposed hip angle changes. Five healthy subjects participated. H-reflexes were measured during hip joint passively flexed and extended in the sagittal plane. In flexion phase, the soleus H-reflex during dynamic conditions was lower than the stationary controls. By contrast, it was conversely higher in extension phase. The findings suggest that the modulation of the soleus H-reflex from hip proprioceptors is a major factor in passive hip movement. Additionally, the central pattern generator might modulate the soleus H-reflex.


Subject(s)
H-Reflex/physiology , Hip , Movement/physiology , Muscle, Skeletal/physiology , Posture/physiology , Range of Motion, Articular/physiology , Adult , Analysis of Variance , Biomechanical Phenomena/methods , Electric Stimulation/methods , Electromyography/methods , Female , Humans , Male
9.
Int J Neurosci ; 115(1): 1-11, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15768847

ABSTRACT

OBJECTIVE: To elucidate whether hip and knee joint movement modulate soleus H-reflex, the authors measured the soleus H-reflex for a very fine angle during movement. METHODS: Eight healthy subjects participated. The knee and hip joints were passively flexed and extended ranging from 0 degrees to 120 degrees simultaneously. RESULTS: In the flexion phase, H-reflex decreased. It decreased more during fast movement. In the extension phase, H-reflex increased markedly. CONCLUSION: By measuring for a fine angle, it was clearly found that the stretch of the muscles around the knee and hip joints caused the changes in soleus H-reflex.


Subject(s)
H-Reflex/physiology , Hip/physiology , Knee Joint/physiology , Movement/physiology , Muscle, Skeletal/physiology , Adult , Biomechanical Phenomena , Electric Stimulation/methods , Electromyography/methods , Female , Humans , Male , Muscle Contraction/physiology , Posture/physiology , Range of Motion, Articular/physiology
10.
Physiol Plant ; 116(2): 248-254, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12354202

ABSTRACT

In non-photosynthetic, yellow or colourless mutant cells of Chlorella kessleri, grown with nitrate as sole nitrogen source, blue light inhibited the uptake of the amino acids glycine, proline and arginine and of ammonia in growing cells, while it enhanced the uptake of these amino acids in resting cells. On the other hand, in cells grown with ammonia as the only nitrogen source without nitrate reductase activity, blue light did not influence the uptake of amino acids and of ammonia in growing cells, while it enhanced the uptake of amino acids in resting cells. Addition of methionine sulphoximine, a potent inhibitor of glutamine synthetase, to growing cells, resulted in intracellular ammonia-accumulation and inhibition of uptake of glycine and of ammonia. For the colourless mutant, blue light was shown to activate purified nitrate reductase. These results indicate that in the mutant cells of Chlorella examined, uptake of ammonia seems to be influenced by nitrate reductase and the uptake of amino acids was influenced by both nitrate reductase and an unknown blue-light-receptor(s). The uptake of urea in mutant cells is not influenced by the irradiation with blue light. Uptake of glycine was also increased after addition of glucose (hexose) in the dark. Because blue light is known to enhance the breakdown of starch, a reaction producing glucose for oxidative degradation in the algae used, the role of glucose (hexose) in the blue light-affected uptake of amino acids is discussed.

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