Large-pore PDS mesh compared to small-pore PG mesh.

BACKGROUND: Currently, absorbable meshes are used as temporary closure in case of laparostoma. Unfortunately the multifilament polyglycolic acid (PG) meshes with small pores reveal little elasticity acting rather as a fluid barrier than permitting drainage of intra-abdominal fluids. Therefore, a new mesh was constructed of absorbable polydioxanon monofilaments (PDS) with increased porosity and longer degradation time. MATERIAL AND METHODS: For evaluation of the tissue response the new PDS mesh was implanted as abdominal wall replacement in each five rats for 7, 21, or 90 days, respectively, and compared to a PG mesh. Histological analysis included HE staining with measurement of the size of the granuloma and immunoshistochemistry for TUNEL, Ki67, TNF-R2, MMP-2, YB1, FVIII, gas6, AXL. Parameters for neovascularization and nerve ingrowth were analyzed. RESULTS: The inflammatory and fibrotic tissue reaction is attenuated with PDS in comparison to PG, e.g., the size of the granuloma was smaller with less cell turnover, and less remodeling as represented by, e.g., reduction of apoptosis, expression of MMP-2, or TNF-R2. The number of ingrowing nerves and vessels explored via AXL, gas6, and factor VIII was increased in the PDS mesh. CONCLUSION: The results from the present investigation showed that a mesh can be constructed of monofilament PDS that induce significant less inflammatory and fibrotic reaction, however permits fluid drainage and preserves elasticity.

Attention in direct and indirect memory tasks with short- and long-term probes.

In two experiments, college students verified the answers to addition problems as their primary task while simultaneously viewing a word or nonword. The degree of attention allocated to the verbal stimulus varied depending on the difficulty of the problem and the instructions given. After each problem, a test probe assessed either a direct test of recognition memory or an indirect test of repetition priming in lexical decision at lags of 0, 1, or 8 intervening trials. The degree of attention at encoding and lag strongly affected recognition sensitivity (d'), but only lag affected recognition latencies. The repetition-priming effect neither declined with lag nor varied with the degree of attention. The degree of attention at encoding thus affects direct and indirect test performance differentially, a finding consistent with the distinction between explicit and implicit systems of long-term memory.