ABSTRACT
The uses of cytokine growth factors in soft tissue applications has been reported on. The scientific background and various processing techniques to prepare the autologous materials are reviewed here. An ongoing research project to study grafting of the maxillary sinus for bone regeneration and implant site preparation with the growth factor Platelet Rich Plasma is outlined.
Subject(s)
Alveolar Bone Loss/surgery , Bone Transplantation/methods , Maxillary Sinus/surgery , Oral Surgical Procedures, Preprosthetic/methods , Platelet Transfusion/methods , Blood Transfusion, Autologous , Calcium Chloride , Centrifugation , Female , Humans , Male , Middle Aged , Plasma , Platelet Transfusion/instrumentation , Platelet-Derived Growth Factor/administration & dosage , ThrombinABSTRACT
Web-based drug ordering allows a growing number of hospitals without pharmacy to communicate seamlessly with their external pharmacy. Business process analysis and object oriented modelling performed together with the users at a pilot hospital resulted in a comprehensive picture of the user and business requirements for electronic drug ordering. The user requirements were further validated with the help of a software prototype. In order to capture the needs of a large number of users CAP10, a new method making use of pre-built models, is proposed. Solutions for coping with the technical requirements (interfacing the business software at the pharmacy) and with the legal requirements (signing the orders) are presented.
Subject(s)
Computer Simulation , Hospital Information Systems , Internet , Pharmacy Service, Hospital , Purchasing, Hospital , Humans , Software DesignABSTRACT
Specimens of buccal mucosa and ear skin were introduced into the uteri of isologous rats and the animals maintained under estrogen stimulation for ten weeks, whereupon the uteri were removed and processed for light- and electron-microscopic examination. The majority of implants were successful with the epithelium having migrated to replace the adjacent uterine epithelium. Epidermis and oral epithelium growing on its own connective tissue in the uterus showed a normal pattern of histodifferentiation, including the formation of a thickened keratinized surface and appendages such as hair and sebaceous glands. Ultrastructurally, maturation was similar to that of normal tissue. Epidermis growing on uterine connective tissue did not form appendages but the ultrastructural pattern of cytodifferentiation was similar to control tissue. Buccal epithelium on the uterine stroma was markedly altered in its pattern of maturation, the epithelium appearing thinner than usual and showing a pattern of maturation resembling that of non-keratinization. These results suggest that normal histodifferentiation in epidermis and oral epithelium requires the presence of the appropriate connective tissue; in its absence epidermis has an intrinsic capacity for more or less normal cytodifferentiation but this is lacking in the buccal epithelium.
