ABSTRACT
We describe a 65-year-old man with a granulomatous hepatitis and a progressive mycotic aneurysm of the abdominal aorta. One year before he received intravesical bacillus Calmette--Guérin (BCG) for carcinoma of the bladder without any complaints. Only post-mortem investigations could confirm that he suffered from a systemic BCG infection. Literature is reviewed for this rare complication.
Subject(s)
Aortic Aneurysm, Abdominal/microbiology , BCG Vaccine/adverse effects , Granuloma, Giant Cell/microbiology , Hepatitis/microbiology , Mycobacterium bovis/pathogenicity , Aged , Aortic Aneurysm, Abdominal/surgery , BCG Vaccine/administration & dosage , DNA, Bacterial , Fatal Outcome , Humans , Immunotherapy, Active/adverse effects , Instillation, Drug , Male , Mycobacterium bovis/isolation & purification , Polymorphism, Restriction Fragment Length , Urinary Bladder Neoplasms/therapyABSTRACT
A total of 14 patients with platinum-resistant advanced epithelial ovarian cancer were treated with a continuous infusion of high-dose 5-fluorouracil (5-FU, 1200 mg/m2 per day) for 2 consecutive days weekly for 4 weeks and, thereafter, every 2 weeks in combination with a push injection of folinic acid (20 mg/m2) given just before 5-FU and after 24 h. No objective response was documented, and only five patients showed stable disease. The median survival was 6.5 months. There was minimal toxicity. This schedule of 5-FU in combination with folinic acid is not effective as second-line chemotherapy in advanced ovarian cancer.
