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1.
Infection ; 39(1): 65-71, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21128092

ABSTRACT

Immune defects in interleukin-12-dependent interferon-gamma (IFN-γ) pathways are associated with disseminated infections caused by non-tuberculous mycobacteria (NTM) and Salmonella. Recently, there have been an increasing number of reports of acquired autoantibodies to IFN-γ in adults, especially in Asian patients. We describe here three human immunodeficiency virus-negative Thai adults who had persistent or recurrent disseminated infections caused by NTM, Salmonella, and other opportunistic pathogens, possibly due to anti-IFN-γ autoantibodies. The antibodies were shown to exhibit very high inhibitory activity to IFN-γ. Two patients also developed Sweet's syndrome during the course of infections. In addition, we also review all previous reports of patients with anti-IFN-γ antibodies who were susceptible to NTM and Salmonella infections.


Subject(s)
Autoantibodies/immunology , Interferon-gamma/immunology , Mycobacterium Infections/diagnosis , Opportunistic Infections/diagnosis , Salmonella Infections/diagnosis , Adult , Humans , Male , Middle Aged , Mycobacterium Infections/complications , Mycobacterium Infections/immunology , Opportunistic Infections/complications , Opportunistic Infections/immunology , Salmonella Infections/complications , Salmonella Infections/immunology , Sweet Syndrome/diagnosis , Thailand
3.
J Investig Allergol Clin Immunol ; 19(6): 509-10, 2009.
Article in English | MEDLINE | ID: mdl-20128430
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