ABSTRACT
Pregnant rabbit females were subjected to daily peroral administration to chlorofos in a dose of 50 and 75 mg per 1 kg of mass for 24 h. It is found to produce an essential effect on oxygen uptake and glycolysis in the placenta tissue. The detected changes expressed in decreased intensity of endogenic respiration and an increased glycolytic activity of the placenta tissue evidence for disturbance in the organ functional state.
Subject(s)
Oxygen Consumption/drug effects , Placenta/metabolism , Trichlorfon/pharmacology , Animals , Female , Glycolysis/drug effects , Kinetics , Placenta/drug effects , Pregnancy , RabbitsABSTRACT
The respiratory and glycolytic activity of the female-rabbits placenta tissue on the 11th and 30th days of pregnancy was studied as affected by progesterone, estrone and chorionic gonadotrophin. The tissue respiration of the placenta at the end of pregnancy is established to be more sensitive to administration of the hormones under study than at the beginning of pregnancy. The glycolytic activity of the placenta tissue under the effect of hormones is decreased both at the beginning and at the end of pregnancy. Only anaerobic glycolysis is an exception when progesterone is administered at the beginning of pregnancy.
