Medication-based treatment among rural, primary care patients diagnosed with opioid use disorder and alcohol use disorder.

INTRODUCTION: Opioid and alcohol use disorders are increasingly being addressed in primary care, yet how medications to treat these disorders are prescribed in rural regions is unknown. METHODS: We determined prevalence, types, and duration of medication prescription for opioid and/or alcohol use disorder among adult patients in rural primary clinics. The sample included 1874 adult patients who visited one of six rural primary care sites in the Northeastern and Northwestern United States at least once from October 2019 to January 2021 and had a diagnosis code for opioid use disorder (OUD), alcohol use disorder (AUD), or co-occurring opioid and alcohol use disorder (OUD + AUD) during that time. RESULTS: Patients with OUD + AUD were more likely to be prescribed medication for at least one of these disorders (85.3 %) than patients with OUD only (63.7 %) or AUD only (10.3 %). Further, the OUD + AUD group had the highest number of days on medication (M = 264.7), followed by OUD only (M = 220.5), then the AUD only group (M = 62.5). Only 8.8 % of patients with OUD + AUD were prescribed naltrexone or medication for OUD + AUD to treat both substance use disorders. CONCLUSIONS: Medications for treating AUD as well as OUD are available, but few patients with OUD + AUD and even fewer with AUD received pharmacological treatment for AUD. The current work highlights the need for rural clinicians to consider medications for AUD as an important treatment method for patients with AUD only or OUD + AUD.

Co-occurring substance use disorders among patients with opioid use disorder in rural primary care clinics.

BACKGROUND: Co-occurring substance use disorders (SUDs) among individuals with opioid use disorder (OUD) are associated with additional impairment, overdose, and death. This study examined characteristics of patients who have OUD with and without co-occurring SUDs in rural primary care clinics. METHODS: Secondary analysis used electronic health record (EHR) data from six rural primary care clinics, including demographics, diagnoses, encounters, and prescriptions of medication for OUD (MOUD), as well as EHR data from an external telemedicine vendor that provided MOUD to some clinic patients. The study population included all adult patients who had a visit to the participating clinics from October 2019 to January 2021. RESULTS: We identified 1164 patients with OUD; 72.6 % had OUD only, 11.5 % had OUD and stimulant use disorder (OUD + StUD), and 15.9 % had OUD and other non-stimulant substance use disorder (OUD + Other). The OUD + StUD group had the highest rates of hepatitis C virus (25.4 % for OUD + StUD, 17.8 % for OUD + Other, and 7.5 % for OUD Only; p < 0.001) and the highest rates of mental health disorders (78.4 %, 69.7 %, and 59.9 %, respectively; p < 0.001). Compared to the OUD Only group, patients in the OUD + StUD and OUD + Other groups were more likely to receive telehealth services provided by clinic staff, in-clinic behavioral health services, and in-clinic MOUD. The OUD + StUD group had the highest proportion of referrals to the external telemedicine vendor. CONCLUSIONS: More than 27 % of patients with OUD in rural primary care clinics had other co-occurring SUDs, and these patients received more healthcare services than those with OUD only. Future studies should examine variations in outcomes associated with these other services among patients with OUD and co-occurring SUDs.

Race Differences in the Association Between Binge Drinking and Treatment Among First-Time Justice-System-Impacted Youth.

AIMS: We aim to determine whether there are racial/ethnic differences in the association between binge drinking frequency and community-based alcohol treatment among justice-system-impacted adolescents and young adults. METHODS: We examined whether race/ethnicity moderated the relation between binge drinking and youths' likelihood of receiving alcohol treatment. The sample included 1216 male, first-time-arrested youth from the Crossroads Study (2011-2018). Participants were recruited from CA, PA and LA. RESULTS: Among youth who binge drank occasionally, Black youth were less likely to receive alcohol treatment than White (b = -0.08, 95% confidence interval [CI] [-0.13, -0.04]) and Hispanic/Latino (b = -0.06, 95% CI [-0.09, -0.02]) youth. There were no differences between the White and Hispanic/Latino youth. Black youth who were frequent binge drinkers were as likely to receive alcohol treatment as White youth who binge drank significantly less often. There were no racial/ethnic differences in alcohol treatment at the highest level of binge drinking. CONCLUSION: Black youth who binge drink occasionally are less likely than White youth to receive alcohol treatment. The present findings highlight a need for efforts to mitigate racial disparities in access to or motivations to seek community-based treatment.

Impact of recreational cannabis legalization on cannabis use, other substance use, and drug-related offending among justice-system-involved youth.

The present study assessed whether cannabis use, other types of substance use, and drug-related offending changed among 1216 justice-system-involved youth after recreational cannabis legalization. Using generalized estimating equation population-averaged models, we compared youth in California, where recreational cannabis is legalized, and Pennsylvania, where recreational use is still prohibited. Results indicated that cannabis use, cannabis selling, and driving under the influences (DUIs) increased more among Pennsylvanian than Californian youth. We found no changes in alcohol or noncannabis drug use after legalization. Cigarette use did not change significantly among Pennsylvanian youth, but Californian youth exhibited decreased cigarette use after legalization. Although not directly tested in the present analysis, it is possible that changes in state-level recreational cannabis policies throughout the U.S. may contribute to more permissive attitudes toward cannabis, which leads to higher use and use-related outcomes. Future research should continue to consider the potential impacts of legalization on other types of risky and illegal behavior.

A Within-Individual Examination of the Predictors of Gun Carrying During Adolescence and Young Adulthood Among Young Men.

Although prior studies have identified several risk factors for gun carrying, no prior longitudinal studies have examined a comprehensive set of explanatory factors together in within-individual change models or examined whether the predictors of gun carrying change across adolescence and early young adulthood. The present study fills these gaps by examining the predictive utility of several risk factors for gun carrying, and by examining whether any of the associations vary by age. The sample included 1216 young men who were arrested for the first time during adolescence (approximately 15 years old) and interviewed regularly for 5 years (until approximately 20 years old) after the first arrest. The outcome was youth-self-reported gun carrying and the risk factors included several variables consistent with various explanations for gun carrying (psychosocial maturity deficits; antisocial behavioral style; socialization; victimization). Research questions were addressed with fixed effects dynamic panel models (within-individual change models). Results showed that the most robust predictors of gun carrying were increased exposure to guns and gun-related violence and increased engagement in other antisocial and illegal behavior. The results emphasize the specific etiology of gun carrying and the potential social contagion effect of gun-related events. Overall, the study points to the need for prevention and intervention programs to specifically target the reduction of the real and perceived prevalence of gun-related events in young men's lives.

Assessing the Association between Participation in Extracurricular Activities and Delinquent Behavior among Justice-Involved Young Men.

Extracurricular activities (ECAs) have been found to promote positive youth development and protect against misconduct and minor delinquency. However, little research has examined whether ECA participation predicts delinquency among at-risk young men or considered how delinquent behavior, in turn, impacts ECA participation. This study examined extracurricular participation over three years in a sample of 1,216 justice-involved young men (Mage  = 15.29). Approximately half of the sample participated in ECA each year. A cross-lagged panel model was used to examine the bidirectional association between ECA participation and two types of delinquency, school misconduct and criminal offending. The results suggest that ECA participation did not consistently predict subsequent delinquency. Rather, justice-involved young men who engaged in more delinquency were less likely to participate in ECAs.

Neighborhood Disorder and Risk-Taking Among Justice-Involved Youth-The Mediating Role of Life Expectancy.

Neighborhood disorder has been linked to perceptions of shorter life expectancies, and shorter life expectancies have been associated with greater risk-taking. Yet, no studies have combined these two pathways. Using data from the longitudinal Crossroads study, the present study assessed whether life expectancy mediates the association between neighborhood disorder and risk-taking-substance use, crime, and risky sex-among 1,093 justice-involved adolescents. Results indicate that neighborhood disorder was linked to lower estimated life expectancy which in turn related to higher rates of cigarette use, binge drinking, illicit drug use, offending, and casual sex. However, life expectancy did not explain the association between neighborhood disorder and marijuana use or inconsistent condom use.

Marijuana Use Among Justice-Involved Youths After California Statewide Legalization, 2015-2018.

Objectives. To determine the impact of California's recreational marijuana legalization on marijuana use among justice system-involved (JSI) adolescents and young adults, and to distinguish whether any changes resulted from legalization (passing the law) or from implementation of the law.Methods. We compared changes in JSI youths' marijuana use in 2 states: California (n = 504), where recreational marijuana use was recently legalized, and Pennsylvania (n = 478), where recreational use is still prohibited. Furthermore, we examined changes in marijuana use across 3 key time periods (October 2015-June 2018): before legalization, after legalization but before implementation, and after implementation.Results. California JSI youths did not demonstrate a significant increase in marijuana use after legalization (b = -0.010; P = .950) or implementation (b = -0.046; P = .846). However, in Pennsylvania, rates of marijuana use increased significantly after legalization (b = 0.602; P = .001) but not after implementation (b = 0.174; P = .533).Conclusions. Although recreational marijuana legalization was not associated with changes in marijuana use among youths in California, we observed increased rates of use in Pennsylvania after legalization in California. Recreational marijuana laws may be indirectly related to youths' marijuana use by supporting more permissive national attitudes toward marijuana.

Adolescents' confidence in institutions: Do America's youth differentiate between legal and social institutions?

It is widely believed that there is a crisis of confidence in law enforcement in the United States. What remains to be seen, however, is whether adolescents actually differentiate between legal authorities and other types of authorities. Leveraging cross-sectional, nationally representative data of 12th graders from every year from 2006 to 2017 from Monitoring the Future (N = 10,941), the results indicate that adolescents distinguish between legal authorities (e.g., law enforcement, justice system) and social authorities (e.g., schools, religious institutions). Youth report more confidence in social authorities than in legal authorities. Furthermore, whereas confidence in social authorities remained largely stable between the cohorts over the last decade, confidence in legal authorities, and in law enforcement in particular, has declined markedly. Although there may be an era of mistrust in legal authorities, it cannot be attributed to a ubiquitous anti-authority attitude among modern adolescents in the United States. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Identification of attractive odorants released by preferred bacterial food found in the natural habitats of C. elegans.

Food choice is critical for survival because organisms must choose food that is edible and nutritious and avoid pathogenic food. Many organisms, including the nematode C. elegans, use olfaction to detect and distinguish among food sources. C. elegans exhibits innate preferences for the odors of different bacterial species. However, little is known about the preferences of C. elegans for bacterial strains isolated from their natural environment as well as the attractive volatile compounds released by preferred natural bacteria isolates. We tested food odor preferences of C. elegans for non-pathogenic bacteria found in their natural habitats. We found that C. elegans showed a preference for the odor of six of the eight tested bacterial isolates over its standard food source, E. coli HB101. Using solid-phase microextraction and gas chromatography coupled with mass spectrometry, we found that four of six attractive bacterial isolates (Alcaligenes sp. JUb4, Providenica sp. JUb5, Providencia sp. JUb39, and Flavobacteria sp. JUb43) released isoamyl alcohol, a well-studied C. elegans attractant, while both non-attractive isolates (Raoultella sp. JUb38 and Acinetobacter sp. JUb68) released very low or non-detectable amounts of isoamyl alcohol. In conclusion, we find that isoamyl alcohol is likely an ethologically relevant odor that is released by some attractive bacterial isolates in the natural environment of C. elegans.

Interpixel crosstalk in Teledyne Imaging Sensors H4RG-10 detectors.

Complementary metal-oxide semiconductor (CMOS)-hybrid arrays have become competitive optical detectors for use in ground- and space-based astronomy. Interpixel capacitance (IPC) is one source of error that appears in most CMOS arrays. In this paper, we use a single-pixel-reset method to model IPC. We combine this IPC model with a model for charge diffusion to estimate the total crosstalk on H4RG-10 arrays. Finally, we compare our model results to 55Fe data obtained using an astrometric camera built to test the H4RG-10 B0 generation detectors.