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1.
J Pharm Biomed Anal ; 176: 112800, 2019 Nov 30.
Article in English | MEDLINE | ID: mdl-31394304

ABSTRACT

The Herpetospermum caudigerum Wall (HCW) is a traditional Tibetan medicine and is widely used in clinical practice. However, the shell of the HCW (SHCW) has rarely been studied, and some researchers have suggested that the SHCW may be toxic. Therefore, in this study, SHCW was administered to rats at two doses (0.1 and 0.33 g/kg) once a day for 21 days. The hepatic stimuli induced by SHCW in rats were investigated for the first time by 1H-NMR-based metabolomics combined with histopathological observation and biochemical detection. Histopathological sections showed a certain degree of hepatocyte edema and hepatic sinus congestion in the liver tissue of the rats in the drug-administered group. Serum biochemical indicators revealed a significant increase in ALT, AST, and MDA, and a significant decrease in SOD. Metabolomic results showed that the metabolites in rats were changed after gavage administration of extracts from SHCW. By multivariate statistical analysis and univariate analysis, it was found that SHCW could cause the disorder of energy metabolism, oxidative stress and amino acid metabolism in rats, leading to liver damage. This comprehensive metabolomics approach demonstrates its ability to describe the global metabolic state of an organism and provides a powerful and viable tool for exploring drug-induced toxicity or side effects.


Subject(s)
Chemical and Drug Induced Liver Injury/diagnosis , Cucurbitaceae/toxicity , Medicine, Tibetan Traditional/adverse effects , Metabolomics/methods , Plant Extracts/toxicity , Proton Magnetic Resonance Spectroscopy , Animals , Biomarkers/blood , Biomarkers/metabolism , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/metabolism , Disease Models, Animal , Ethanol/chemistry , Humans , Liver Function Tests/methods , Male , Plant Extracts/isolation & purification , Rats
2.
Zhongguo Zhong Yao Za Zhi ; 38(10): 1621-3, 2013 May.
Article in Chinese | MEDLINE | ID: mdl-23947151

ABSTRACT

Zuotai is an essential part in Tibetan patent medicine, which plays an important role in treating diseases. This paper introduced the invention, preparing process, use, effectiveness, and safety of Zuotai, aimed to provide an insight for traditional Chinese medicine when using heavy mental within Chinese patent medicine.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Medicine, Tibetan Traditional/history , Mercury Compounds/therapeutic use , Phytotherapy/history , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/history , History, Ancient , Humans , Mercury Compounds/chemistry , Mercury Compounds/history , Tibet
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