[Neopterine and ige during respiratory-syncytial virus infection in infants].

The number of studies confirms the correlation between IgE and neopterine levels. One of the forms of revelation of the immune answer of T-cells is the activation of T-cell system, that in its turn results in secretion of IL-2 and INF-gamma by Th-1 subtype cells. Activation of macrophages by INF-gamma the human organism. The target of our research was the evaluation of the role of the marker of macrophage activation -- neopterine in children with recurrent wheezing developed during onset of RSV infection and possible connection with IgE level. In the study 52 children of age from 1 to 12 months having RS-virus infection were included. Two groups were determined as controls -- group of healthy children and children with wheezing of non RSV etiology. Determination of neopterine was performed by enzyme immunoassay method (ELISA). During the RS-virus induced acute respiratory infection the rate of neopterine in the blood serum was significantly decreased in the group of patients with recurrent wheezing in comparison with the I group (first episode of wheezing). At the same time the significant difference between the group with wheezing of non -- RSV etiology and the control group was not observed. Decreasing of neopterin was significant in the II and III groups. IgE levels were elevated significantly in the second group of patients with recurrent wheezing. In this group negative correlation between neopterin and IgE was found.

[INF-gamma during respiratory-syncytial induced obstructive respiratory syndrome in infection in children under one year of age].

Lately the connection of Asthma and RSV drew the sufficient attention. The recurrent wheezing developed during the RSV in children is particularly frequent in the families having history of atopy. The decreased expression of INFgamma may play the role in the pathogenesis of RSV infection. The target of our research was the study of the rate of INFgamma during various clinical courses of RSV-infection and definition of its role in the pathogenesis of ARVI. 52 children with RSV-associated wheezing have been studied, who had first (32) or recurrent episode (20) of bronchial obstruction and whose families had occurrence of atopy. 52 children with non RSV-associated wheezing (III group) and 10 healthy children up to 12 months of age (IV group) were considered as the control groups. Children from all four groups were from families with the history of atopy. INFgamma was measured by enzyme immunoassay (ELISA). Comparison of two groups of wheezing children with RSV infection showed significant reduction of INFgamma level in the group of children with recurrent wheezing vs. the group with first episode of wheezing. INFgamma levels were significantly higher in the two control groups. During the acute respiratory infection induced by RS-virus, which proceeds with the obstruction of respiratory tract (wheezing), reduction of INFgamma was noted and higher frequency of wheezing episodes is associated with more prominent alteration.