ABSTRACT
The paper is concerned with the experimental data on a ERP signal size in two blood plasma metalloproteins--ceruloplasmin and transferrin and their correlations after intraperitoneal hydrocortisone and corticotropin injections (5 mg and 2.5 U/100 g body weight, respectively) to Wistar adult male rats and after bilateral adrenalectomy. A conclusion has been made that antioxidant activity of the ceruloplasmin-transferrin complex in rat blood plasma is increased with a rise of the corticotropin level but it is decreased with hydrocortisone loading.
Subject(s)
Ceruloplasmin/analysis , Pituitary-Adrenal System/physiology , Transferrin/analysis , Adrenalectomy , Adrenocorticotropic Hormone/pharmacology , Animals , Ceruloplasmin/drug effects , Electron Spin Resonance Spectroscopy , Hydrocortisone/analogs & derivatives , Hydrocortisone/pharmacology , Male , Pituitary-Adrenal System/drug effects , Rats , Rats, Inbred Strains , Time Factors , Transferrin/drug effectsSubject(s)
Isoxazoles/toxicity , Lipid Peroxidation/drug effects , Microsomes, Liver/drug effects , Mitochondria, Liver/drug effects , Oxazoles/toxicity , Animals , Cytochrome P-450 Enzyme System/metabolism , Enzyme Activation/drug effects , Isoxazoles/pharmacology , Male , Microsomes, Liver/metabolism , Mitochondria, Liver/metabolism , Oxidation-Reduction/drug effects , RatsABSTRACT
Experimental investigations indicate that localized forms of staphylococcal, Pseudomonas aeruginosa and associated (Pseudomonas aeruginosa-staphylococcal) infection inhibit the lysozyme activity, cause disorders in the metabolism of P-450 cytochrome, free-radical and iron-containing liver proteins.
