1.
NIDA Res Monogr
; 79: 48-58, 1987.
Article
in English
| MEDLINE
| ID: mdl-3125480
ABSTRACT
Cannabidiol (CBD) exhibits anticonvulsant activity in experimental animals and in man. As part of a structure-activity study, analogs were prepared wherein the terpene unit, the aryl unit, and/or the side chain were modified. Thus, several pinenyl and carenyl derivatives, aryl ethers and acetates, and a variety of 1",1"-dialkylhexyl and 1",1"-dialkylheptyl analogs were synthesized. The compounds were evaluated for anti-convulsant activity in seizure susceptible (AGS) rats and for neurotoxicity in the rat rotorod (ROT) test. Comparisons of stereoisomers of CBD and several analogs revealed a general lack of stereoselectivity for anticonvulsant and other CNS properties of this class of compounds.
Subject(s)
Anticonvulsants , Cannabidiol/pharmacology , Cannabinoids/pharmacology , Animals , Cannabidiol/analogs & derivatives , Disease Models, Animal , Dose-Response Relationship, Drug , Rats , Seizures/drug therapy , Structure-Activity Relationship
2.
J Am Chem Soc
; 91(18): 5190-1, 1969 Aug 27.
Article
in English
| MEDLINE
| ID: mdl-5798103
3.
Tetrahedron Lett
; (7): 591-3, 1969 Feb.
Article
in English
| MEDLINE
| ID: mdl-5775268
4.
J Am Chem Soc
; 90(23): 6551-3, 1968 Nov 06.
Article
in English
| MEDLINE
| ID: mdl-5682456