1.
Chemistry
; 19(10): 3311-4, 2013 Mar 04.
Article
in English
| MEDLINE
| ID: mdl-23386512
ABSTRACT
Functionalized alkylzinc halides can be employed in the enantioselective addition to aldehydes by using a titanium(IV) catalyst derived from a H(8)-binaphthol derivative in the presence of [Ti(OiPr)(4)] and MgBr(2). A range of functionalities, including olefin, chlorine atoms, protected alcohols, amides, and cyano groups, are tolerated in the present reaction, providing the corresponding functionalized alcohols in high yields and enantioselectivities (see scheme).