ABSTRACT
BACKGROUND: Several registries and centers have reported the results of renal biopsies from different parts of the world. As there are few data regarding the epidemiology of glomerulonephritis (GN) in South Korea, we conducted this study on renal biopsy findings during the last 20 years from a single center. METHODS: Data for 818 patients who underwent renal biopsy at our center between 1992 and 2011 were collected retrospectively. All kidney specimens were examined with light microscopy (LM) and immunofluorescent microscopy (IF). RESULTS: There were 818 cases of native kidney biopsies. In cases of primary GN, the most frequent type of renal pathology in adults (18-59 years) was mesangial proliferative GN (MsPGN, 34.5%) followed by IgA nephropathy (IgAN, 33.3%) and membranous GN (MGN, 8.8%). Indications in adults (18-59 years) were asymptomatic urinary abnormalities (75.3%) followed by nephrotic syndrome (19.8%) and acute kidney injury (AKI, 3.4%). CONCLUSIONS: Among 818 renal biopsy specimens, MsPGN and IgAN were the most frequent biopsy-proven renal diseases. MGN was the third most common cause of primary GN and lupus nephritis (LN) was the most common secondary glomerular disease. Our data contribute to the epidemiology of renal disease in South Korea.
Subject(s)
Glomerulonephritis, IGA/epidemiology , Glomerulonephritis, Membranoproliferative/epidemiology , Glomerulonephritis, Membranous/epidemiology , Kidney/pathology , Lupus Nephritis/epidemiology , Acute Kidney Injury/epidemiology , Acute Kidney Injury/pathology , Acute Kidney Injury/urine , Adult , Aged , Aged, 80 and over , Biopsy , Female , Glomerulonephritis, IGA/pathology , Glomerulonephritis, IGA/urine , Glomerulonephritis, Membranoproliferative/pathology , Glomerulonephritis, Membranoproliferative/urine , Glomerulonephritis, Membranous/pathology , Glomerulonephritis, Membranous/urine , Hematuria/epidemiology , Hematuria/pathology , Hematuria/urine , Humans , Lupus Nephritis/pathology , Lupus Nephritis/urine , Male , Microscopy, Fluorescence , Middle Aged , Nephrotic Syndrome/epidemiology , Nephrotic Syndrome/pathology , Nephrotic Syndrome/urine , Proteinuria/epidemiology , Proteinuria/urine , Republic of Korea/epidemiology , Retrospective Studies , Young AdultABSTRACT
We investigated the relationship between geriatric nutritional risk index (GNRI) and subpopulation lymphocyte counts (SLCs) in hemodialysis (HD) and peritoneal dialysis (PD) patients and evaluated whether they can be helpful in the diagnosis of malnutrition in these patients. We examined the GNRI and SLCs of 50 HD patients (mean: 55.8 ± 12.7 years; 28 men and 22 women) and 16 Continuous Ambulatory Peritoneal Dialysis (CAPD) patients (mean: 49.8 ± 14.5 years; 10 men and six women). The GNRI is calculated based on the serum albumin level, dry weight, and ideal body weight and uses the following equation: GNRI = [14.89 × albumin (g/dL)] + [41.7 × (weight/ideal body weight)]. SLCs were evaluated using flow cytometry. T-tests and χ2 tests were performed to compare the two groups. Logistic regression analysis was performed for predicting malnutrition in dialysis patients. The average GNRI value was 100.1 ± 8.4 in HD patients and 99.2 ± 8.1 in PD patients, and no significant differences in GNRI or SLC were observed between the two groups. SLCs were higher in patients with higher GNRI (GNRI ≥ 100) although there was no statistical difference. Logistic regression for predicting malnutrition according to GNRI revealed that age, female sex, and CD19 counts predicted malnutrition in HD and PD patients. These results suggest that GNRI and SLCs (especially CD19 count) may be significant nutritional markers in these patients.
