ABSTRACT
BACKGROUND AND OBJECTIVES: Recently, functional studies for auditory cortex are being watched with interest in accordance with development of many radiologic equipments and surgical devices for sensorineural hearing loss. Moreover, it is well known that the function of central auditory pathway is essential for hearing rehabilitation. There are some papers that reported about the functional or metabolic changes of auditory cortex in deafness and in patients with cochlear implantation. The aim of this study was to investigate indirectly the metabolic changes of primary auditory cortex and visual cortex in the c-fos immunoreactivity in an experimentally induced permanent threshold shift animal model. MATERIALS AND METHOD: Ototoxic drugs (kanamycin and furosemide) and noise were used for the induction of permanent threshold shift. Cochlear damages were evaluated with auditory brainstem responses (ABR) and morphologic studies. The c-fos immunoreactivity was observed with a lapse of time after deafening. RESULTS: After the administration of ototoxic drugs and noise exposure, ABR threshold shifts were not recovered until after three months. Cochlear damages were observed in broad areas of cochlea. The c-fos immunoreactivity in the primary auditory cortex was increased during the acute period but it was decreased after one month. In addition, it was recovered again within the level of control three months later. In the visual cortex, increased and sustained immunoreactivities were observed after the drug and noise exposure. CONCLUSION: This result shows the plasticity of auditory cortex and possibility of some kinds of auditory-visual cross modal plasticity.
Subject(s)
Animals , Humans , Auditory Cortex , Auditory Pathways , Cochlea , Cochlear Implantation , Cochlear Implants , Deafness , Evoked Potentials, Auditory, Brain Stem , Guinea , Guinea Pigs , Hearing , Hearing Loss, Sensorineural , Noise , Plastics , Visual CortexABSTRACT
A number of genetic and environmental factors influence athletic performance. Cardiovascular fitness is an important factor of athletic success, and ACE gene is a good candidate for regulating cardiac and vascular function. Because younger subjects have less chance of being exposed to environmental factors than older ones, genetic factors have a relatively greater influence on younger subjects. The aim of this study was to investigate the distribution of I/D polymorphism in the ACE gene between Korean young controls and athletes. By association study, there were no significant differences in genotype and allele distributions between two groups, respectively (P> 0.05). When stratified by sporting disciplines, the significant difference in distribution was not also detected in our study (P> 0.05). These results do not support the hypothesis that the I/D polymorphism in the ACE gene is associated with endurance performance in Korean young subjects.
Subject(s)
Humans , Alleles , Athletes , Athletic Performance , Genotype , SportsABSTRACT
No abstract available.
Subject(s)
Humans , Emergencies , Emergency Service, Hospital , Statistics as TopicABSTRACT
The clinical study was made on 52 cases who had treated for congenital syphilis at Chonnam University Medical School Hospital. Of these, 39 cases were admitted to Pediatric Department of C.U.M.S.H. from Jan. 1971 to Dec. 1978 via out patient dispensary and 13 cases were born in C.U.M.S.H. form Jan. 1974 to Dec. 1978. The results were summarized as followings; 1) 8% of the total low birth weight infants and 0.5% of the infants who weighed over 2,500gm at birth were diagnosed as congenital syphilis. 2) In sex distribution 36 were male and rest of them were female. 3) 70% among congenital syphilitic patients in low birth weight infants had prematurity. 4) The first clinical sympton appeared 89.4% within the fourth week after birth, 53.9% in the first week and 9.6% after the fourth week. 5) The most frequent clinical manifestation was hepatomegaly(79%), next in order of skin manifestaion(72%), anemia(60%), splenomegaly(48%), rhinitis and snuffle(48%). 6) In V.D.R.L. test, 96% of the patient, 98% of the mother and 72% of the father revealed reactive response. 7) Bony changes of roentgenographic examination were detected in 47 cases(90%). 8) 16 cases of congenital syphilitic patients in low birth weight infants(52 cases) and 8 cases of congenital syphilitic patiets who weighed over 2,500gm at birth were died and the most common cause of death in the patients of low birth weight infants was prematurity.
