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1.
Wiad Lek ; 54 Suppl 1: 297-300, 2001.
Article in Polish | MEDLINE | ID: mdl-12182038

ABSTRACT

The absence of iodine uptake in metastases of differentiated thyroid carcinoma makes them unresponsive to treatment with radioiodine 131I. In many of such cases symptomatic treatment remains the only available therapy. The results of studies on partial redifferentiation of metastases of thyroid cancer achieved after cis-retinoid acid therapy have drawn attention to the possibility of restoration of iodine uptake in metastases after pretreatment with cis-retinoic acid (Roaccutane). 5 patients with iodine uptake-negative metastases of differentiated thyroid carcinoma were given Roaccutane in a dose 1.5 mg/kg/24 h daily for 6 weeks before the therapy with radioiodine. In none of the patients restoration of radioiodine uptake in metastases has occurred as shown in post-therapeutic total body scintigraphy.


Subject(s)
Adenocarcinoma, Follicular/secondary , Carcinoma, Papillary/secondary , Iodine Radioisotopes/pharmacokinetics , Isotretinoin/administration & dosage , Premedication , Thyroid Neoplasms/metabolism , Thyroid Neoplasms/radiotherapy , Adenocarcinoma, Follicular/metabolism , Adenocarcinoma, Follicular/radiotherapy , Adult , Aged , Bone Neoplasms/metabolism , Bone Neoplasms/radiotherapy , Bone Neoplasms/secondary , Carcinoma, Papillary/metabolism , Carcinoma, Papillary/radiotherapy , Female , Humans , Isotretinoin/adverse effects , Lung Neoplasms/metabolism , Lung Neoplasms/radiotherapy , Lung Neoplasms/secondary , Thyroglobulin/metabolism , Thyroid Neoplasms/drug therapy
2.
Wiad Lek ; 54 Suppl 1: 357-62, 2001.
Article in Polish | MEDLINE | ID: mdl-12182048

ABSTRACT

UNLABELLED: Technetium 99mTc(TF), non-specific tumor-searching tracer was evaluated for its ability to detect distant metastases of differentiated thyroid carcinoma (DTC) and its reliability in the follow-up of DTC. Whole body scintigraphy (wbs) was performed 20-30 min after intravenous injection of 740 MBq 99mTc tetrofosmin by means of a dual-head gamma-camera (followed by spot images if needed) in 61 patients (pts) with DTC; 52 pts with distant metastases in 131I whole body scintigraphy (34) or in other methods (x-ray, CT, ultrasound) (7) or with negative 131I whole body scan and elevated thyroglobulin (11). In the group of 52 pts with signs of neoplasm dissemination, 36 showed positive TF whole body scan (69%), 16 (31%) pts were TF-negative. 23 of 34 131I positive wbs were also TF positive (68%), 11 out of 34 were TF negative (32%). In a group of 7 pts with metastases in x-ray, CT or ultrasound 4/7 were positive (57%), 3/7 were TF negative (18%). In a control group of 11 persons (2 diseases-free, 9 with DTC in clinical remission) TF whole body scans were negative in all cases. CONCLUSIONS: Technetium 99mTc tetrofosmin is clinically useful for detecting distant metastases of differentiated thyroid carcinoma and deserves complementary clinical application in follow-up in such patients.


Subject(s)
Bone Neoplasms/secondary , Lung Neoplasms/secondary , Neoplasm Recurrence, Local/diagnostic imaging , Organophosphorus Compounds , Organotechnetium Compounds , Thyroid Neoplasms/diagnostic imaging , Bone Neoplasms/diagnostic imaging , Follow-Up Studies , Humans , Lung Neoplasms/diagnostic imaging , Lymphatic Metastasis , Radionuclide Imaging , Reproducibility of Results
3.
Wiad Lek ; 54 Suppl 1: 398-404, 2001.
Article in Polish | MEDLINE | ID: mdl-12182056

ABSTRACT

Hypoparathyroidism remains a serious complication of total thyroidectomy for differentiated thyroid carcinoma (DTC). In Brachytherapy Department 952 patients affected with DTC were followed up in the years 1996-2000. Radical total thyroidectomy was performed in 235 (24.6%) of cases, while the other 717 patients underwent complete rethyroidectomy. The incidence of hypoparathyroidism following radical operation and after complete rethyroidectomy was 15.74% and 23.43%, respectively. In patients operated in our institution, blood for calcium was analyzed daily for five days following the surgery. If calcium level was normal the next measurement was performed 4-5 weeks thereafter. Hypoparathyroidism was diagnosed later in postoperative period in many patients operated elsewhere. Asymptomatic hypocalcemia during the first week after the operation requires oral administration of calcium. If hypocalcemia requiring intravenous calcium supplementation does not resolve in a few days, vitamin 1(OH)D3 is introduced. Vitamin 1(OH)D3 and calcium carbonate play the main role in management of persistent hypocalcemia. In case of marked hypercalciuria thiazid diuretics are instituted. Low-phosphate diet is recommended. The aim of treatment of hypoparathyroidism is to restore normal serum calcium level with calciuria not exceeding 5 mg/kg/24 h, so to avoid hypocalcemic complications as well as vitamin D intoxication.


Subject(s)
Hypoparathyroidism/etiology , Thyroid Neoplasms/surgery , Thyroidectomy/adverse effects , Calcium/administration & dosage , Follow-Up Studies , Humans , Hypocalcemia/drug therapy , Hypocalcemia/etiology , Thyroid Neoplasms/pathology
6.
Immunohematology ; 2(3): 62-3, 1986.
Article in English | MEDLINE | ID: mdl-15945863
20.
Acta Endocrinol (Copenh) ; 95(2): 172-6, 1980 Oct.
Article in English | MEDLINE | ID: mdl-6108033

ABSTRACT

In order to elucidate the role of the adrenergic nervous system in the mechanism of TSH release in men the effects of alpha- and beta-receptors blocking agents were studied in 11 healthy volunteers. Phentolamine administered iv as a bolus injection in a dose of 10 mg, significantly lowered the TSH release in basal condition and in response to TRH stimulation. However, propranolol in a dose of 0.1 mg/kg administered in the same fashion as phentolamine had no effect on the TSH secretion. The results obtained suggest that the alpha-receptors of the adrenergic system are involved in the physiological mechanism which stimulates TSH release in men.


Subject(s)
Receptors, Adrenergic, alpha/physiology , Receptors, Adrenergic, beta/physiology , Receptors, Adrenergic/physiology , Thyrotropin/metabolism , Adolescent , Adrenergic alpha-Antagonists , Adrenergic beta-Antagonists , Adult , Female , Humans , Male , Phentolamine/pharmacology , Propranolol/pharmacology , Thyroxine/blood , Triiodothyronine/blood
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