ABSTRACT
PURPOSE: Glucocorticoids have particularly strong impact on the thromboembolic complications. A factor which increases the risk of thrombosis is hyperhomocysteinemia, observed in patients with hypercortisolemia. Proinflammatory factors also affect the haemostatic balance. There has been an extensive research which estimates hemostatic system in patients with Cushing's syndrome. Undoubtedly, much fewer publications are available on thromboembolic complications in patients with Subclinical Cushing's Syndrome (SCS). The purpose of this study was to estimate of homocysteine (HCY) and alpha-1 antitrypsin (α1ATp) concentrations in patients with SCS. MATERIALS AND METHODS: We studied 35 patients (56.0 ± 15.0 years) with SCS and 33 healthy volunteers (53.3 ± 17.7 years). In all subjects the analysis of HCY and α1ATp concentration in serum was determined with an immunonephelometric method. P-values below 0.05 were considered statistically significant. RESULTS: A comparison of HCY and α1ATp mean concentrations in patients with SCS and healthy representatives indicated statistically higher values of both analysed parameters in the sera of patients than in the healthy controls (p values were 0.018 and 0.008, respectively). In the patients with SCS a negative correlation between α1ATp and cortisol concentration in overnight dexamethasone test was found (p=0.017, R=-0.40). We did not reveal any statistically significant correlation between the concentrations of HCY and α1ATp, and coagulation parameters such as INR, APTT, fibrinogen concentration in patients with SCS. CONCLUSIONS: On the basis of the obtained results, a slight increase in the concentration of homocysteine and α1ATp is observed in patients with SCS, which may influence vascular complications.
Subject(s)
Cushing Syndrome/blood , Homocysteine/blood , alpha 1-Antitrypsin/blood , Adult , Aged , Case-Control Studies , Cushing Syndrome/complications , Female , Humans , Hydrocortisone/blood , Hyperhomocysteinemia/blood , Hyperhomocysteinemia/complications , Male , Middle Aged , Thromboembolism/blood , Thromboembolism/etiologyABSTRACT
La sensibilidad aumentada de los detectores en los aeropuertos, el aumento del número de pruebas isotópicas y la globalización de la sociedad han dado lugar a varias falsos positivos en las alarmas de radioactivos de los aeropuertos y lugares públicos. Este trabajo presenta dos nuevos casos de pacientes que alertaron las alarmas de seguridad en el aeropuerto después de haber recibido 740MBq de 131I en bocio no-tóxico. Los intentos de comparar la literatura son sorprendentemente limitados en relación a este problema. Un hombre de 57 años desencadenó una alarma en tres aeropuertos diferentes durante los días 17, 28 y 31 después de haber recibido exposición a yodo radioactivo. Curiosamente, mientras tanto, en los días 18 y 22, no se detectó la radiación en el aeropuerto, donde fue detenido dos veces más adelante como fuente de radiación. El segundo caso presenta una mujer de 45 años que activó los detectores de la alama de seguridad cuando cruzó una frontera en un viaje en autobús después de haber recibido yodo radioactivo(AU)
An increased sensitivity of airport detectors, a growing number of isotopic tests, and globalization of the society have raised a number of false positive radioactive alarms at airports and public places. This paper presents two new cases of patients who triggered airport security alarms after receiving 740MBq of 131I for non-toxic goitre and attempts to compare surprisingly limited literature concerning this problem. A 57-year-old man triggered a security alarm at three different airports on the 17th, 28th, and 31st day after radioiodine exposure. Interestingly enough, in the meantime, on the 18th and 22nd day, no radiation was detected in him at the airport where he was twice detained as a source of radiation later on. The second case presents a 45-year-old woman who activated security alarm detectors while crossing a border on her coach trip 28 days after radioiodine administration(AU)
Subject(s)
Humans , Male , Middle Aged , Iodine Radioisotopes/analysis , Sanitary Control of Airports and Aircrafts , Airports/legislation & jurisprudence , Airports/methods , Airports/trends , Goiter, Endemic/drug therapy , Radiation , Safety/standards , Airports/instrumentation , Airports/standards , Radioactive Waste/analysis , Goiter, Endemic/therapyABSTRACT
An increased sensitivity of airport detectors, a growing number of isotopic tests, and globalization of the society have raised a number of false positive radioactive alarms at airports and public places. This paper presents two new cases of patients who triggered airport security alarms after receiving 740MBq of (131)I for non-toxic goitre and attempts to compare surprisingly limited literature concerning this problem. A 57-year-old man triggered a security alarm at three different airports on the 17th, 28th, and 31st day after radioiodine exposure. Interestingly enough, in the meantime, on the 18th and 22nd day, no radiation was detected in him at the airport where he was twice detained as a source of radiation later on. The second case presents a 45-year-old woman who activated security alarm detectors while crossing a border on her coach trip 28 days after radioiodine administration.
