GROUNDWATER AND DRINKING WATER RADON CONCENTRATIONS IN THE COASTAL AND INTERIOR AREAS OF CHENNAI METRO CITY AND ITS IMPACT ON PUBLIC HEALTH.

One hundred forty-eight water samples were collected from in and around Chennai and 222Rn concentrations were measured using radon emanometry method. The average 222Rn concentration was estimated to be 6.88, 2.01, 1.17, 0.19 and 0.10 Bq L-1 for borewell water, openwell water, tank water, metro water and lake water, respectively, which were within the U.S. Environmental Protection Agency's (USEPA) Standard limit of 11.1 Bq L-1 and World Health Organization (WHO) global average 10 Bq L-1. The total effective dose obtained has varied from 0 to 157.57 µSv y-1 with ±10% standard deviation. The mean values were 19.608, 8.092, 4.692, 0.761 and 0.423 µSv y-1 for closed borewell, open well water, tank water, metro water and for lake water, respectively. All these values were below the reference point 0.1 mSv y-1 (100 µSv y-1) set by WHO.

Diagnosis of major organic acidurias in children: two years experience at a tertiary care centre.

Organic acid disorders are inherited metabolic disorders in which organic acids accumulate in tissues and biological fluids of affected individuals. Classical organic acidurias include methylmalonic aciduria, propionic aciduria, isovaleric aciduria and maple syrup urine disease (MSUD). They are considered the most frequent metabolic disorders among severely ill children. Patients frequently present with acute symptoms early in life. 420 cases clinically suspected to have organic aciduria, with upper age limit of 12 years for a 2-year period (January 2007-December 2008) were enrolled into this study. Metabolic acidosis and neurological symptoms were the most common signs. Screening tests and thin layer chromatography were done for detection of organic acidurias. Identification and quantitation of organic acids in urine and quantification of amino acids in blood were done by high performance liquid chromatography. Out of 420 patients, 45 patients (10.7%) were found to have organic acidurias. 15 cases of methylmalonic aciduria, 16 cases of propionic aciduria, 13 cases of MSUD, and one case of isovaleric aciduria were diagnosed. Results demonstrate the importance of testing for organic acidurias. Since organic aciduria may cause irreversible brain damage if not treated, we recommend selective screening amongst severely ill children despite implied extra costs.