ABSTRACT
BACKGROUND: Lipids play a key role in the maintenance of cell integrity. These are major cell membrane components essential for various biological functions, including cell growth and division of normal and malignant tissues. Abnormal changes have long been associated with alterations in lipid profile. AIM: The aim of this study was to evaluate the alterations in lipid profile in oral submucous fibrosis (OSMF) patients and to compare the levels with respect to the clinical staging and histological grading. MATERIALS AND METHODS: Fifty patients of OSMF, diagnosed clinically and histopathologically, were included as the study subjects. A group of 50 age and sex matched normal subjects without any oral pernicious habits were taken as controls. The serum lipid profile consisting of total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and low density lipoprotein (LDL) were analyzed using Erba Chem-5 Plus Analyzer. RESULTS: Serum TC, HDL and LDL levels were significantly decreased in OSMF patients as compared to controls. As the clinical stage progresses, the TC and HDL levels were gradually reduced. All the lipid profile parameters such as TC, TG, HDL, VLDL and LDL progressively reduced as the histological grade advanced. CONCLUSION: The results of the present study showed that there is an inverse relationship between lipid profile and the presence of OSMF. The decreased serum lipid profile may be considered as a useful indicator for initial changes occurring in the cells of potentially malignant disorders like OSMF.
ABSTRACT
BACKGROUND: Individual identification is a subtle concept and often one of the most important priorities in mass disasters, road accidents, air crashes, fires, and even in the investigation of criminal cases. Matching specific features detected on the cadaver with data recorded during the life of an individual is an important aspect in forensics, and can be performed by fingerprint analysis, deoxyribonucleic acid matching, anthropological methods, radiological methods and other techniques which can facilitate age and sex identification. Sinus radiography is one such method that has been used for determination of the sex of an individual. Hence, an attempt is being made to use the different dimensions of the maxillary sinus in the determination of sex using coronal and axial sections of plain computed tomography (CT) scan. MATERIALS AND METHODS: A total of 30 patients including 17 male and 13 female, visiting the Outpatient Department of the Mamata General Hospital were included as the study subjects. The dimensions of right and left maxillary sinuses of 30 subjects from plain CT were measured using SYNGO software and statistical analysis was done. RESULTS: Sex determination using height, length, width, and volume of the maxillary sinus on both sides showed statistically significant results with a higher percentage of sexual dimorphism in the case of volume. CONCLUSION: Volume of the right maxillary sinus can be used as accurate diagnostic parameter for sex determination.
