1.
Org Lett
; 9(24): 5095-8, 2007 Nov 22.
Article
in English
| MEDLINE
| ID: mdl-17956114
ABSTRACT
Dynamic kinetic resolution of allylic alcohols to allylic acetates followed by copper-catalyzed allylic substitution gave alkenes in high yields and high optical purity. Subsequent oxidative C-C double bond cleavage afforded pharmaceutically important alpha-methyl substituted carboxylic acids in high ee.