1.
Curr Med Chem
; 20(14): 1824-46, 2013.
Article
in English
| MEDLINE
| ID: mdl-23410152
ABSTRACT
Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.