ABSTRACT
Real-time temperature monitoring within biological objects is a key fundamental issue for understanding the heating process and performing remote-controlled release of bioactive compounds upon laser irradiation. The lack of accurate thermal control significantly limits the translation of optical laser techniques into nanomedicine. Here, we design and develop hybrid (complex) carriers based on multilayered capsules combined with nanodiamonds (NV centers) as nanothermometers and gold nanoparticles (Au NPs) as nanoheaters to estimate an effective laser-induced temperature rise required for capsule rupture and further release of cargo molecules outside and inside cancerous (B16-F10) cells. We integrate both elements (NV centers and Au NPs) in the capsule structure using two strategies: (i) loading inside the capsule's cavity (CORE) and incorporating them inside the capsule's wall (WALL). Theoretically and experimentally, we show the highest and lowest heat release from capsule samples (CORE or WALL) under laser irradiation depending on the Au NP arrangement within the capsule. Applying NV centers, we measure the local temperature of capsule rupture inside and outside the cells, which is determined to be 128 ± 1.12 °C. Finally, the developed hybrid containers can be used to perform the photoinduced release of cargo molecules with simultaneous real-time temperature monitoring inside the cells.
Subject(s)
Fluorescent Dyes/chemistry , Metal Nanoparticles/chemistry , Polymers/chemistry , Thermometry/methods , Animals , Cell Line, Tumor , Drug Liberation , Fluorescent Dyes/toxicity , Gold/chemistry , Gold/radiation effects , Gold/toxicity , Indoles/chemistry , Light , Magnetic Resonance Spectroscopy/methods , Metal Nanoparticles/radiation effects , Metal Nanoparticles/toxicity , Mice , Polymers/toxicity , Temperature , Thermometry/instrumentationABSTRACT
The routing of light in a deep subwavelength regime enables a variety of important applications in photonics, quantum information technologies, imaging and biosensing. Here we describe and experimentally demonstrate the selective excitation of spatially confined, subwavelength electromagnetic modes in anisotropic metamaterials with hyperbolic dispersion. A localized, circularly polarized emitter placed at the boundary of a hyperbolic metamaterial is shown to excite extraordinary waves propagating in a prescribed direction controlled by the polarization handedness. Thus, a metamaterial slab acts as an extremely broadband, nearly ideal polarization beam splitter for circularly polarized light. We perform a proof of concept experiment with a uniaxial hyperbolic metamaterial at radio-frequencies revealing the directional routing effect and strong subwavelength λ/300 confinement. The proposed concept of metamaterial-based subwavelength interconnection and polarization-controlled signal routing is based on the photonic spin Hall effect and may serve as an ultimate platform for either conventional or quantum electromagnetic signal processing.
ABSTRACT
We suggest and verify experimentally the concept of functional metamaterials whose properties are remotely controlled by illuminating the metamaterial with a pattern of visible light. In such metamaterials arbitrary gradients of the effective material parameters can be achieved simply by adjusting the profile of illumination. We fabricate such light-tunable microwave metamaterials and demonstrate their unique functionalities for reflection, shaping, and focusing of electromagnetic waves.
