ABSTRACT
Stages of modeling of polyetiological electrolyte nephropathy in rats are described. Morphological study confirmed the presence of interstitial and tubular disorders in rat kidneys. The model is intended for studies of the mechanisms underlying the formation, development, and correction of nephrological diseases.
Subject(s)
Disease Models, Animal , Kidney Diseases/etiology , Kidney Diseases/pathology , Animals , Electrolytes , Magnesium Deficiency/complications , Male , Potassium Deficiency/complications , Rats , Rats, Wistar , Sodium Chloride/toxicityABSTRACT
We elaborated a model of gastroduodenitis combined with hyperlipidemia in rats. This model is based on alimentary lipid disturbances and morphological changes in the gastroduodenal mucosa caused by exogenous damaging factors. Morphological assay revealed gastroduodenitis; biochemical studies of the blood and liver demonstrated hyperlipidemia. This model holds much promise for evaluating pathogenetic mechanisms of combined gastroduodenal and heart diseases.
