Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.

Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain development in infancy and early childhood (from birth to age 6 years). This is an important knowledge gap because developmental changes in the brain during the prenatal and early postnatal period are regulated by dynamic gene expression patterns that likely play an important role in establishing an individual's risk for later psychiatric illness and neurodevelopmental disabilities. In this review, we summarize findings from imaging genetics studies spanning from early infancy to early childhood, with a focus on studies examining genetic risk for neuropsychiatric disorders. We also introduce the Organization for Imaging Genomics in Infancy (ORIGINs), a working group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium, which was established to facilitate large-scale imaging genetics studies in infancy and early childhood.

A meta-analysis of mental rotation in the first years of life.

Mental rotation, the cognitive process of moving an object in mind to predict how it looks in a new orientation, is coupled to intelligence, learning, and educational achievement. On average, adolescent and adult males solve mental rotation tasks slightly better (i.e., faster and/or more accurate) than females. When such behavioral differences emerge during development, however, remains poorly understood. Here we analyzed effect sizes derived from 62 experiments conducted in 1705 infants aged 3-16 months. We found that male infants recognized rotated objects slightly more reliably than female infants. This difference survives correction for small degrees of publication bias. These findings indicate that gender differences in mental rotation are small and not robustly detectable in the first months of postnatal life. RESEARCH HIGHLIGHTS: We analyzed effect sizes of 62 mental rotation experiments including 1705 infants. Looking time reveals that 3-16-months-old infants are able to perform mental rotation. Mental rotation is slightly more reliable in male infants compared to female infants. Gender difference in mental rotation is robust to small degrees of publication bias.

In silico evaluation of potential intervention against SARS-CoV-2 RNA-dependent RNA polymerase.

Background: With few available effective interventions, emergence of novel mutants responding poorly to existing vaccines and ever swelling newer waves of infection, SARS-CoV-2 is posing difficult challenges to mankind. This mandates development of newer and effective therapeutics to prevent loss of life and contain the spread of this deadly virus. Nsp12 or RNA-dependent RNA polymerase (RdRp) is a suitable druggable target as it plays a central role in viral replication. Methodology: Catalytically important conserved amino acid residues of RdRp were delineated through a comprehensive literature search and multiple sequence alignments. PDB ID 7BV2 was used to create binding pockets using SeeSAR and to generate docked poses of the FDA approved drugs on the receptor and estimating their binding affinity and other properties. Result: In silico approach used in this study assisted in prediction of several potential RdRp inhibitors; and re-validation of the already reported ones. Five molecules namely Inosine, Ribavirin, 2-Deoxy-2-Fluoro-D-glucose, Guaifenesin, and Lamivudine were shortlisted which exhibited reasonable binding affinities, with neither torsional nor intermolecular or intramolecular clashes. Conclusion: This study aimed to widen the prospect of interventions against the SARS-CoV-2 RdRp. Our results also re-validate already reported molecules like 2-Deoxy-D-glucose as a similar molecule 2-deoxy-2-fluoro-D-glucose is picked up in this study. Additionally, ribavirin and lamivudine, already known antivirals with polymerase inhibition activity are also picked up as the top leads. Selected potent inhibitors of RdRp hold promise to cater for any future coronavirus-outbreak subject to in vitro and in vivo validations.