ABSTRACT
OBJECTIVE: The current study aimed to assess the effects of tonsillar herniation on cervical alignment in Chiari I patients without syringomyelia using new cervical sagittal alignment parameters, such as C0-2 Cobb angle, C2-7 cobb angle, T1 slope, and C2-7 sagittal vertical axis (SVA). METHODS: Two spinal surgeons independently evaluated midline T2-weighted sagittal magnetic resonance imaging findings of 28 Chiari I patients without syringomyelia and 40 patients without tonsillar herniation but with similar complaints. Thereafter, the measured C0-2 Cobb angle, C2-7 Cobb angle T1 slope, and C2-7 SVA were compared using the t-test. RESULTS: Differences in the mean values for C2-7 Cobb angle, T1 slope, and C2-7 SVA were found between Chiari I patients and those without tonsillar herniation. CONCLUSION: The current study showed that Chiari I patients were less lordotic (kyphotic) compared to subjects without tonsillar herniation.
Subject(s)
Arnold-Chiari Malformation , Kyphosis , Syringomyelia , Arnold-Chiari Malformation/diagnosis , Arnold-Chiari Malformation/diagnostic imaging , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/surgery , Encephalocele , Humans , Kyphosis/surgery , Magnetic Resonance Imaging , Retrospective Studies , Syringomyelia/diagnostic imagingSubject(s)
Hamartoma/surgery , Meningomyelocele/surgery , Ossification, Heterotopic/surgery , Spinal Diseases/surgery , Hamartoma/complications , Hamartoma/diagnostic imaging , Humans , Magnetic Resonance Imaging , Male , Meningomyelocele/complications , Meningomyelocele/diagnostic imaging , Ossification, Heterotopic/complications , Ossification, Heterotopic/diagnostic imaging , Spinal Diseases/complications , Spinal Diseases/diagnostic imaging , Young AdultABSTRACT
OBJECTIVE: It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients. PATIENTS AND METHODS: We included 41 patients with acromegaly and 65 healthy subjects with similar age and sex to the study. Fasting plasma glucose (FPG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG) were analyzed. Genotyping was made by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The frequency of genotype and allel ICAM-1 E469K was not significantly different between control and patients (p > 0.05). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG levels were significantly higher, and HDL-C was significantly lower in patients with KK genotypes compared to patients with EE genotype in acromegaly group (p < 0.05). CONCLUSIONS: This is the first study to investigate the role of ICAM gene polymorphism in acromegaly and its cardiovascular characteristics. ICAM E469K may not be a risk factor for the acromegaly in Turkish population but may be associated with hypertension, higher FPG and lower HDL-C in acromegalic patients.
