Upper and lower cervical alignment parameters measured on supine magnetic resonance imaging with the occipital slope as a key marker of cervical alignment.

Objectives: Cervical spine alignment is evaluated by measuring the cervical angles or parameters on standing plain radiography. In this study, we aimed to evaluate mainly the upper cervical alignment and the correlation between upper and lower cervical sagittal parameters measured on supine magnetic resonance imaging (MRI). Materials and Methods: Cervical MRIs of 210 outpatients were reviewed to measure the upper and lower cervical sagittal parameters. Their mean values were compared with normative values measured on standing X-ray from the literature. Correlations between the parameters were analyzed using the Pearson's correlation coefficient. Results: The C0 slope was correlated with all other parameters, except for the C2-7 sagittal vertical axis. The strongest correlations (r > 0.500) were between the CL and C2 slope, between the CO2 and C0 slope, and between the C2 slope and C0 slope. Conclusion: On supine MRI, the C0 slope is a key marker of cervical spinal alignment. A strong correlation was observed between the C2 slope and C0 slope; therefore, the relationship between upper and lower cervical alignment could be assessed using slopes on MRI.

L1 slope: an overlooked spinal parameter.

OBJECTIVE: Lumbar lordosis can be divided into two parts by a horizontal line, creating the L1 slope and the sacral slope. Despite being a major spinopelvic parameter, the L1slope (L1S) is rarely reported. However, there is some evidence that L1S is a relatively constant parameter. This study aimed to analyze the L1 slope and its relationships with other spinopelvic parameters. METHODS: Standing lateral lumbosacral x-ray radiographies of 76 patients with low back pain and CT scans of 116 asymptomatic subjects were evaluated for spinal and spinopelvic parameters including L1 slope (L1S). The x-ray and CT groups were divided into subgroups according to mean sacral slope (SS) or pelvic incidence (PI) values. The mean values of the spinopelvic parameters and the correlations between them were investigated and compared. RESULTS: L1S was 19.70 and 18.15 in low SS and high SS subgroups of x-ray respectively. L1S was 7.95 and 9.36 in low and high PI subgroups of CT, respectively, and the differences were insignificant statistically. L1S was the only spinal parameter that did not change as SS or PI increased in standing and supine positions. L1S was correlated with lumbar lordosis (LL) proximal lumbar lordosis (PLL) and distal lumbar lordosis (DLL) in both x-ray and CT groups. L1S was also the strongest correlated parameter with pelvic incidence lumbar lordosis mismatch (PI-LL) mismatch in supine position. CONCLUSIONS: L1S is a relatively constant parameter and is around 16°-18° and 8°-9° in the standing and supine positions, respectively. It was significantly correlated with LL, PLL, DLL, and PI-LL. In the standing position it was nearly equal to PLL while this equality was present in low PI subgroups of CT. There is strong evidence that L1S is significantly correlated with health-related quality of life scores.

A simple method for the selection of valid spinopelvic parameters and lumbar lordosis in patients with transitional lumbosacral vertebrae.

PURPOSE: Transitional lumbosacral vertebrae (TLSV) are a congenital anomaly of the lumbosacral region that is characterized by the presence of a vertebra with morphological properties of both the lumbar and sacral vertebrae, with a prevalence of up to 36% in asymptomatic patients and 20% in adolescent idiopathic scoliosis patients. In patients with TLSV, because of these morphological changes and the different numbers of lumbar vertebrae, there are two optional reference sacral endplates that can be selected intently or inadvertently to measure the spinopelvic parameters: upper and lower endplates. The spinopelvic parameters measured using the upper and lower endplates are significantly different from each other as well as from the normative values. Therefore, the selection of a reference endplate changes the spinopelvic parameters, lumbar lordosis (LL), and surgical goals, which can result in surgical over- or under-correction. Because there is no consensus on the selection of sacral endplate among these patients, it is unclear as to which of these parameters should be used in diagnosis or surgical planning. The present study describes a standardization method for measuring the spinopelvic parameters and LL in patients with TLSV. METHODS: Upper and lower endplate spinopelvic parameters (i.e., pelvic incidence [PI], sacral slope [SS], and pelvic tilt) and LL of 108 patients with TLSV were measured by computed tomography. In addition, these parameters were measured for randomly selected subjects without TLSV. The PI value in the TLSV group, which was closer to the mean PI value of the control group, was accepted as valid and then used to create an optimum PI (OPI) group. Finally, the spinopelvic parameters and LL of the OPI and control groups were compared. RESULTS: Except for SS, all spinopelvic parameters and LL were comparable between the OPI and control groups. In the OPI group, 60% of the patients showed valid upper endplate parameters, and 40% showed valid lower endplate parameters. No difference was noted in the frequency of valid upper or lower endplates between the sacralization and lumbarization groups. Both the OPI and control groups showed nearly comparable correlations between their individual spinopelvic parameters and LL, except for PI and LL in the former. CONCLUSIONS: Because PI is unique for every individual, the endplate whose PI value is closer to the normative value should be selected as the reference sacral endplate in patients with TLSV.

Analysis of Spinopelvic Parameters and Lumbar Lordosis in Patients with Transitional Lumbosacral Vertebrae, with Special Reference to Sacralization and Lumbarization.

BACKGROUND: Transitional lumbosacral vertebra presents in 2 forms based on its origin: sacralization and lumbarization. These patients have 2 options for sacral endplates (upper and lower) and consequently, 2 sets of values for spinopelvic parameters and lumbar lordosis (LL). This study aimed to evaluate these parameters in asymptomatic patients with sacralization and lumbarization and compare them with each other and normative values. METHODS: Spinopelvic parameters and LL according to upper and lower endplate were measured using abdominal computed tomography in 1420 asymptomatic patients, of which 108 had Transitional lumbosacral vertebra. These parameters were compared among patients with lumbarization and sacralization and with normal controls. In addition, correlations between the upper and lower endplate parameters were determined. RESULTS: As compared to the control group, upper endplate measurements yielded lower spinopelvic parameters and LL values while lower endplate values yielded higher values. While these values were significantly different from normative values, these parameters were similar in both lumbarization and sacralization groups. Furthermore, most spinopelvic parameters of both upper and lower endplates were strongly correlated, and the differences between the upper and lower PI and LL values are relatively constant (27° and 14°, respectively. CONCLUSIONS: Upper and lower endplate parameters are comparable in patients with sacralization and lumbarization; therefore, the average spatial position of a sacralized L5 and a lumbarized S1 within the pelvis is similar and either parameter can be used for radiological measurements. Further studies with symptomatic patients are warranted to confirm these results.

Posterior Pubic Incidence: A Novel Morphologic Spinopelvic Parameter Nearly Equal to Pelvic Incidence.

BACKGROUND: Pelvic incidence (PI) and Jackson's angle are 2 major spinopelvic parameters that define the position of the sacrum within the pelvis. These parameters are measured on standing lateral radiography, and the identification of the hip axis is essential for measurements. Moreover, identifying the hip axis in patients with hip diseases or femoral head deformity is challenging. In this study, we described a novel parameter named posterior pubic incidence (PPI) that could be measured using the posterior pubic edge instead of the hip axis. METHODS: Group A comprised 50 volunteers who underwent standing lateral lumbosacral radiography. Group B comprised 54 patients with abdominal or urologic problems who underwent supine computed tomography. The PI, pelvic tilt (PT), sacral slope, PPI, and posterior pubic tilt were measured. The differences between PI and PPI were evaluated. Linear regression analysis was used to predict the PI value from PPI. RESULTS: The mean PI and PPI values were 47.41° ± 12.32° and 49.32° ± 11.94° in group A and 49.19° ± 9.99° and 49.99° ± 9.25° in group B, respectively. The mean absolute differences in groups A and B were 2.41° ± 1.63° and 1.9° ± 1.62°, respectively. High correlations were obtained between PI/PPI and pelvic tilt/posterior pubic tilt. PI could be calculated as PI° = PPI° - 2° on plain radiography and as PI° = PPI° - 1° on computed tomography. CONCLUSIONS: PPI was strongly correlated with PI, which was nearly equal to PI, and may replace PI in formulas containing PI.

Analysis of Components of Upper Cervical Lordosis in Asymptomatic Lordotic and Kyphotic Subjects.

BACKGROUND: Upper cervical lordosis (CL) can be divided into 2 components: C2 slope (C2S) and McGregor slope (MGS) or C0-1 and C1-2 angles. The aim of this study was to investigate the components of upper CL in asymptomatic kyphotic and lordotic subjects. METHODS: CL, C0-2 Cobb angle, MGS, C2S, C1 Slope, C0-1 Cobb angle, C1-2 Cobb angle, T1 slope angular parameters, and the C2-7 sagittal vertical axis distance of 78 asymptomatic subjects were measured. RESULTS: Sixty subjects had lordotic curvature and 18 had kyphotic curvature. There was a significant difference between the kyphotic and lordotic groups in all parameters, except for C0-1 Cobb angle and C2-7 sagittal vertical axis. In lordotic subjects, MGS and C2S accounted for 58% and 42% of the C0-2 angle, whereas in kyphotic subjects, 86% of C0-2 was accounted for by C2S. There was a strong negative correlation between C2S and MGS. CONCLUSIONS: In asymptomatic subjects, as CL decreases, MGS decreases, C2S increases, and the C0-2 angle turns down on the horizontal plane to maintain the horizontal gaze. Turning down the C0-2 angle is more important than its value for maintaining horizontal gaze; thus, the slopes (MGS and C2S) can better represent the upper and lower cervical alignment than angle values can. The relationship between upper and lower cervical alignment should be evaluated in terms of slope angles rather than simple angles. The lack of significant difference between the C0-1 angles in the kyphotic and lordotic groups suggests that only the C1-2 angle is involved in the compensatory mechanism for the horizontal gaze.

Calvarial Tumors: A Retrospective Analysis and Clinical Experience.

AIM: To elucidate the prognosis, frequency, and diverse nature of pathologies for calvarial tumors among different age groups. MATERIAL AND METHODS: Seventy-six patients who underwent surgery for calvarial lesions between January 2007 and March 2021 are included in this study. Clinical data obtained retrospectively from patients? electronic records. Radiological images and surgical notes are reviewed to determine extent of the tumor and resection. RESULTS: Among 76 patients, 33 (43.4%) were male and 43 (56.6%) were female. The mean age was 36.0 years (range: 1?81 years) at the time of initial operation. Children consisted 28.9% (n=22) of the patients. In children, 59.1% (n=13) had tumor-like pathologies, while 27.3% (n=6) had benign pathologies, and 13.6% (n=3) had malignant tumors. In the adult population, 42.6% (n=23) had malignant tumors, 31.5% (n=17) had benign tumors, 16.7% (n=9) had tumor-like pathologies, and 9.2% (n=5) had intermediate-grade tumors. F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan was performed in 16 patients, 10 cases underwent whole-body bone scintigraphy (WBBS), and 4 cases underwent both. Among these examinations, 16 (80%) of the FDG-PET scans and 5 (35.7%) of the WBBS scans revealed an extracranial pathological lesion. A calvarial tumor was diagnosed in 13 of 18 cases of metastatic lesions (72.2%) before the primary tumor detection. CONCLUSION: Lesions of the calvarium include malignant tumors, intermediate grade tumors, tumor-like lesions, and benign tumors. These masses may be the first presentation in patients with underlying primary tumors. In our study, the malignant tumor rate in the calvaria was 34.2%, and 72.2% of the metastatic tumors were diagnosed with a calvarial resection before the primary tumor was found. Operating a calvarial lesion and making an early diagnosis are crucial for the treatment of the primary lesions.

Validity and Reliability of Spinopelvic Parameters Measured on Computed Tomography.

BACKGROUND: This study aimed to measure pelvic incidence (PI) and other spinopelvic sagittal parameters on supine computed tomography (CT) and to assess the validity and reliability of measurements from supine CT images when compared with standing x-ray images. Difficulties in superimposition of femur heads and obtaining the perfect midsagittal view of the sacral endplate may cause relatively low intra- and interobserver agreements. Some authors reported that PI values measured by CT had higher reliability, but both validity and reliability of CT measurement of spinopelvic parameters compared with standing x-ray imaging methods have not been reported previously. METHODS: PI, pelvic tilt (PT), and sacral slope (SS) were measured on standing lateral x-ray and spinopelvic supine CT images of 33 asymptomatic volunteers. RESULTS: The mean PI, PT, and SS in standing x-ray images were 45.2°, 10°, and 35.3°, respectively, whereas those in supine CT images were 44.5°, 8.2°, and 36.2°, respectively. No significant differences were found in each parameter. Excellent correlations were found between each parameter obtained from x-ray and CT images. Intra- and interobserver reliabilities were excellent in both x-ray and CT image measurements, although those from CT images were higher. CONCLUSION: Spinopelvic sagittal parameters could be measured on supine CT by using a simple method with high reliability and validity; thus, CT could be a good alternative to standing x-ray imaging. In the supine position, PI does not change but PT decreases by a small amount and SS increases almost by the same amount because of the mathematical relationship between PT and SS (PI = PT + SS). CLINICAL RELEVANCE: Supine CT is an efficient diagnostic tool for the reliable extraction of spinopelvic sagittal parameters.

Simulating upright cervical lordosis in the supine position.

Cervical alignment or lordosis evolution is still attained by direct radiography in standing position because an ideal cervical curvature is essential to maintain a horizontal gaze with minimal energy consumption. However, upright cervical lordosis changes in supine position. Anterior fusion surgery and more sophisticated radiological examinations, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI), are performed in lying position. Therefore, if upright cervical alignment can be simulated in the supine position, true (upright) cervical lordosis can be demonstrated on CT and MRI and also a more proper anterior cervical fusion can be performed in operation with better surgical outcomes. Forty-nine (49) adult patients underwent radiological examinations, including upright cervical radiography and three session of supine MRI in different positions. MRI was performed in (1) conventional neutral supine position, (2) supine position with a 5-cm-high pillow, and (3) supine position with a 10-cm-high pillow under the shoulders. MRI results were analyzed. Wilcoxon, Kolmogorov-Smirnov, and Spearman correlation tests were used to analyze MRI the validity in compared with those of cervical radiography. Cervical lordosis (C2-C7 Cobb angle) of the radiography group was similar to that of supine MRI group using a 5-cm-high pillow, and they have a strong correlation. The T-1 slope from radiography group was similar to and correlated with that of supine MRI groups with both pillows. Cranial tilt measurements of radiography group were different but correlated with the MRI group using a 5-cm-high pillow. Simulating upright cervical lordosis in the supine position is possible by adding a 5-cm- high pillow under the shoulders of the patients. This simulation reduces the need for direct radiography. Anterior cervical fusion surgery performed in this position can provide better surgical results.

Pelvic incidence measurement with supine magnetic resonance imaging: A validity and reliability study.

OBJECTIVE: Classically, pelvic incidence (PI) and other spinopelvic sagittal parameters are measured using plain x-ray obtained with the patient standing. However, it is difficult to obtain a perfect mid-sagittal appearance of the sacral endplate and superimposition of both femoral heads from a plain x-ray. Overlapping of the iliac wings also could obscure the appearance of the sacral endplate. Recent studies showed that MRI was more reliable than x-ray for evaluating some spinal sagittal parameters. To our knowledge, measurements of spinopelvic sagittal parameters using supine MRI have not been reported previously. We assessed the validity and reliability of measurements of spinopelvic sagittal parameters from standing lateral x-rays and supine magnetic resonance imaging (MRI). METHODS: We recruited 26 asymptomatic volunteers for this study. Standing lateral lumbosacral radiographs, including femoral heads and spinopelvic MRI images with coronal images of the femoral heads were performed. The anatomic reference point required to measure PI was found on coronal MRI images and transferred to the midline sagittal MRI using the bladder wall as a second reference point. PI, sacral slope (SS), and pelvic tilt (PT) were measured on x-ray and MRI images. Validity and reliability of results also were tested. RESULTS: Of 14 males and 12 females (average age, 31.30), PI was obtained from x-ray and MRI in 52. ± 6.89 and 51.42 ± 6.43, respectively. From standing x-ray to supine MRI, PT decreased by 3.16°, while SS increased 2.5°. A paired t-test showed a significant difference between PT values from x-ray and MRI. The correlation was highest between the x-ray and MRI measurements of PI, PT, and SS, respectively. Intraobserver and interobserver reliabilities were between 0.88 and 0.96 on x-ray and MRI. All reliabilities were excellent, although MRI values were higher. CONCLUSION: MRI was more reliable in the measurement of spinopelvic parameters than classic standing x-ray examination. Higher reliability and being radiation-free could make MRI a good alternative to standing x-ray.

Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.

AIM: We aimed to show whether ischemia reperfusion (I/R) injury causes damage on brain or not, and whether thymoquinone and silymarin, as antioxidant and anti-inflammatory herbs, have beneficial effects on this damage or not. METHODS: Forty Wistar albino rats were carried out and were randomized to 4 groups with equal numbers (n=10): sham group, implemented of only anesthesia; control group, implemented of anesthesia and I/R injury; silymarin group, implemented of anesthesia and I/R injury and treated with a dose of 200 milligram/kg silymarin ip and thymoquinone group, implemented of anesthesia and I/R injury and treated with a dose of 20 mg/kg thymoquinone. Serum lipid hydroperoxide (LOOH) and total free sulfhydryl (Sh) levels were determined. Light microscopy was used to evaluate histological changes in brain tissue. RESULTS: Serum LOOH levels (0.21 ± 0.04 for control group, 0.29 ± 0.01 for sham group, 0.23 ± 0.09 for silymarin group, 0.29 ± 0.09 for thymoquinone group) were significantly higher and Sh levels (10.74 ± 1.71 for control group, 6.82 ± 0.24 for sham group, 9.12 ± 1.04 for silymarin group, 8.41 ± 1.12 for thymoquinone group) were significantly lower in control, silymarin and thymoquinone groups compared to control group (p<0.05 for all). According to the histopathologic damage score assessment, it was seen that the damage decreased significantly in the silymarin and the thymoquinone groups. CONCLUSION: We showed that tissue damage also occurs in brain following the ischemia reperfusion. It was shown that thymoquinone and silymarin is quite effective in preventing this damage. KEY WORDS: Brain, Hydroperoxide levels, Ischemia reperfusion injury, Sulfhydryl levels, Silymarin, Thymoquinone.

Frontoethmoid Osteoma Causing Tension Pneumocephalus.

Tension pneumocephalus is a life-threatening condition that is characterized by the accumulation of intracranial air, causing increased intracranial pressure. Paranasal sinus osteomas are common, slow-growing benign tumors usually diagnosed incidentally. Paranasal sinus osteomas causing tension pneumocephalus have been very rarely reported.

Non-dysraphic intramedullary lipoma of the craniocervical region in an adult: Case report / Lipoma intramedular no disráfico de la región craneocervical en un adulto: informe de un caso

Intradural spinal lipomas with intracranial extension are very rare and are typically diagnosed in childhood. Radical surgical excision usually causes a high rate of morbidity because of the firm adherence between the lipoma and neural tissues. In this report, we present a case of craniocervical intradural intramedullary lipoma in an adult patient. The patient underwent surgery with excision of the mass, leaving a sheet of lipoma on the tumor bed

Los lipomas espinales intradurales con extensión intracraneal son muy raros y suelen diagnosticarse en la infancia. La escisión quirúrgica radical generalmente causa una alta tasa de morbilidad debido a la adherencia firme entre el lipoma y los tejidos neurales. En este artículo, presentamos un caso de lipoma intramedular craneocervical intradural en un paciente adulto. El paciente se sometió a una cirugía con exéresis de la masa, dejando una lámina de lipoma en el lecho tumoral

Non-dysraphic intramedullary lipoma of the craniocervical region in an adult: Case report.

Intradural spinal lipomas with intracranial extension are very rare and are typically diagnosed in childhood. Radical surgical excision usually causes a high rate of morbidity because of the firm adherence between the lipoma and neural tissues. In this report, we present a case of craniocervical intradural intramedullary lipoma in an adult patient. The patient underwent surgery with excision of the mass, leaving a sheet of lipoma on the tumor bed.

The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children.

BACKGROUND: Oxidative stress may induce brain injury. Thiols are one of the most important antioxidant agents, and thiol/disulphide (SH/SS) homeo stasis is a novel oxidative stress marker. The goal of the study was to investigate the relationship of thiol levels and SH/SS homeostasis with head trauma in pediatric patients. METHODS: This prospective study was conducted in 85 consecutive pediatric patients aged < 18 years with isolated head trauma and 58 age- and gender-matched healthy controls in the Emergency Department (ED). RESULTS: The mean age was 4.40 ± 3.03 years for the patient group and 4.75 ± 1.81 years for the controls (p > 0.05). There were no significant differences in biochemical parameters including serum albumin, urea, alanine aminotransferase, total bilirubin, uric acid, high-sensitivity C-reactive protein (hs-CRP), and white blood cells (WBC) in the patient and control groups (for each, p > 0.05). The thiol (SH) level was significantly higher in the patient group than in the controls (388.83 ± 51.949 vs. 369.04 ± 37.62 µmol/L; p = 0.009). The total thiol (TT) level was somewhat higher in the patient group, but the difference was not significant (416.11 ± 47.29 vs. 405.08 ± 35.27 µmol/L; p = 0.113). The disulphide (SS) level was lower in the patient group (p < 0.001). The SS/SH and SS/TT ratios were significantly lower in the patient group, while the SH/ TT ratio was significantly higher (p < 0.001). CONCLUSIONS: Analysis of serum thiol levels and SH/SS homeostasis might be useful in order to determine the head trauma in pediatric patients.

The Assessment of Upright Cervical Spinal Alignment Using Supine MRI Studies.

STUDY DESIGN: This is a prospective, single-centre study. OBJECTIVE: The purpose of this study is researching whether there is a correlation or not between the cervical alignment in the examinations of magnetic resonance imaging (MRI) in lying position and the alignment in the cervical direct radiography and whether the cervical alignment in standing position could be estimated or not through MRI measurements in the supine position. SUMMARY OF BACKGROUND DATA: Cervical spinal alignment is a parameter required for deciding the surgical procedure particularly in patients with cervical myelopathy and deformity. However, cervical alignment angles change according to lying and standing positions. Therefore, the direct standing radiograph is taken as basis for this examination. METHODS: Cervical alignments were measured with 3 different methods with the standing lateral radiographies and lying MRI of 51 patients with cervical disorder. RESULTS: A high correlation was found between the measurements in standing and lying positions for the spinal alignments measured through the Cobb angle and posterior tangent method. It was found that standing Cobb angle (in plain graphy)=Cobb angle (in MRI)×0.489+7.13 and posterior tangent angle (in plain graphy)=posterior tangent angle (in MRI)×0.54+9.37. CONCLUSIONS: It is possible to estimate the spinal alignment in standing position with the measurements of cervical spinal alignment in the MRI at supine position. And this may render having cervical graphy in standing position unnecessary.

Surgical treatment of pseudotumor cerebri.

AIM: To share our experience with idiopathic intracranial hypertension. MATERIAL AND METHODS: All patients believed to have pseudotumor cerebri underwent a fundus oculi examination to confirm the existence of papillary stasis and lumbar puncture (LP) to measure cerebrospinal fluid (CSF) pressure. Patients who did not respond to medical treatment underwent fundus oculi examinations at 3-week intervals. Patients with CFS pressures exceeding 240 mm H2O underwent at least three LPs at 3-day intervals. Patients with higher CFS pressures were treated surgically. RESULTS: The mean patient age was 40.8 (range 31-58) years and the mean body mass index (BMI) was 30.9 (range 28.8-36.4) kg/m2. Papillary stasis was observed in 15 (46.8%) cases. The mean initial CSF pressure was 455.6 (range 360-560) mmHg, and after a mean of 4.3 (range 3-6) repeat measurements, this decreased to 213.4 (range 160-320) mmHg (Table I). Complications in our series included a lumbar pouch in three patients, and an abdominal pouch, meningitis, and abdominal migration in one patient each. DISCUSSION: Surgical treatment of idiopathic intracranial hypertension is necessary when the intracranial pressure does not decrease despite medical treatment and repeat LP. CONCLUSIONS: Idiopathic intracranial hypertension is a clinical syndrome of unclear pathogenesis that is closely related to obesity. KEY WORDS: Cerebrospinal fluid, Idiopathic intracranial hypertension, Pseudotumor cerebri, Obesity.

Evaluation of ceruloplasmin levels in patients with lumbar disc herniation.

BACKGROUND: Chronic inflammation is believed to have a role in the development of lumbar disc herniation (LDH). Ceruloplasmin (CP), an acute phase protein, is known to limit inflammation. OBJECTIVE: To evaluate CP levels in patients with LDH. METHODS: Thirty-five patients with LDH and 35 healthy individuals were enrolled in the study. Participants were divided into two groups; group 1 (n = 35) consisted of patients with LDH, and group 2 (n = 35) consisted of healthy subjects. Surgery specimens were taken from all patients who underwent LDH-related surgery. CP levels were measured in both blood and tissue samples. Pain intensity was evaluated using a visual analog scale (VAS). RESULTS: There were no significant differences in gender, age, or body mass index between the control and LDH patients (p > 0.05 for all). Compared with the control patients, LDH patients had significantly higher serum CP levels (p < 0.001). In LDH patients, tissue CP levels were significantly higher than serum levels (p < 0.001). According to bivariate analysis, the serum CP levels were significantly correlated with the VAS score in group 1 (r = 0.491, p = 0.003). CONCLUSIONS: The present study showed that CP levels increased in both the serum and the tissues of patients with LDH compared to patients without LDH, possibly as a consequence of LDH-associated inflammation.

Arthroplasty versus fusion for single-level cervical disc disease.

OBJECTIVE: To evaluate the effectiveness and safety of cervical arthroplasty and anterior cervical discectomy fusion methods. METHODS: The randomised clinical trial was conducted at the neurosurgical clinic of University of Harran, Turkey, between February 2009 and January 2010. The patients had single level disc disorder between C4-C7 levels. Before surgery, all of the patients had taken medical treatment with no improvement. Surgery was conducted with anterior approach, and disc prosthesis or polyetheretherketone cage for fusion were applied after patients were randomly divided into two groups. For preoperative and postoperative clinical evaluations Neck Disability Index and Visual Analogue Scale were used. Surgical results were evaluated according to Odom's criterion, and 'excellent' and 'good' results were accepted as successful. P<0.05 was taken as statistically significant. RESULTS: Of the 42 patients in the study, 23(54.76%) were treated with Anterior Cervical Discectomy and Fusion, and 19(45.23%) with Cervical Disc Arthroplasty. There were no statistical differences between postoperative mean Visual Analogue Scale score (p<0.86) and Neck Disability Index scores (p<0.11) in the two groups. Average decrease in lordosis angle was 1.2 degree in Arthroplasty group, while it was 1 degree in the Fusion group. Postoperative adjacent segment degeneration was not detected in either group. CONCLUSION: Anterior Cervical Discectomy and Fusion, and Cervical Disc Arthroplasty are safe and successful methods for the treatment of single level cervical disc disease. Although the latter is a relatively new technique performed with increased frequency, but its superiority is still uncertain.