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1.
Clin Invest Med ; 40(5): E188-E199, 2017 10 19.
Article in English | MEDLINE | ID: mdl-29061224

ABSTRACT

PURPOSE: Hyperglycemia is the major risk factor for microvascular complications in type 2 diabetes mellitus (T2DM) patients. This randomized controlled clinical trial aimed to investigate T2DM patients with microvascular complications with regard to possible relations among serum clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) activities. METHODS: Subject groups were defined as follows: T2DM without complications (n=25, F/M=9/16, age 53.9±11.1 years); T2DM+Retinopathy (n=25, F/M=13/12, age 63.8±7.1 years); T2DM+Nephropathy (n=25, F/M=13/12, age 58.7±14.4 years); T2DM+Neuropathy (n=25, F/M=15/10, age 63.2±9.6 years); and healthy control subjects (HC) (n=25). CLU, amylin, SFRP-4, DPP-4 and GLP-1 (total and active) activities were measured and compared in blood samples from type 2 diabetic patients with and without microvascular complications. RESULTS: Significantly lower levels of DPP-4 and GLP-1total (P.


Subject(s)
Diabetes Mellitus, Type 2/blood , Diabetic Nephropathies/blood , Diabetic Retinopathy/blood , Dipeptidyl Peptidase 4/blood , Glucagon-Like Peptide 1/blood , Hyperglycemia/blood , Adult , Aged , Female , Humans , Male , Middle Aged
3.
Scand J Gastroenterol ; 41(7): 862-5, 2006 Jul.
Article in English | MEDLINE | ID: mdl-16785202

ABSTRACT

Hepatic hydrothorax is a complication of cirrhosis that is uncommon and difficult to treat. Diuretic therapy, thoracentesis, transjugular intrahepatic portosystemic shunt and liver transplantation are the main therapeutic options. Here, we report on a 47-year-old man with decompensated liver cirrhosis related to hepatitis B and D virus infections and who had complications of hepatic hydrothorax and hepatorenal syndrome. In this case, the hepatic hydrothorax, which was refractory to thoracic tube drainage and octreotide treatment, could be controlled with 5 days of terlipressin therapy associated with albumin. Terlipressin administration resulted in both improvement in renal function and successful resolution of hepatic hydrothorax. Splanchnic vasoconstrictor agents that reduce splanchnic blood flow, increase both central volume and effective renal blood flow. Thus they improve renal function. In our case, terlipressin, known to be beneficial in hepatorenal syndrome, was also effective in the treatment of hepatic hydrothorax probably by similar mechanisms. This is the first case in the literature.


Subject(s)
Hydrothorax/drug therapy , Hydrothorax/etiology , Liver Cirrhosis/complications , Lypressin/analogs & derivatives , Vasoconstrictor Agents/therapeutic use , Albumins/therapeutic use , Hepatitis B/complications , Hepatitis D/complications , Humans , Lypressin/therapeutic use , Male , Middle Aged , Terlipressin
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