Subject(s)
Lymphoma, Non-Hodgkin/epidemiology , Sarcoidosis/epidemiology , Anti-Inflammatory Agents/administration & dosage , Comorbidity , Female , Humans , Lymphoma, Non-Hodgkin/immunology , Middle Aged , Prednisone/administration & dosage , Sarcoidosis/diagnosis , Sarcoidosis/drug therapy , Sarcoidosis/immunologySubject(s)
Nail Diseases/diagnosis , Nail Diseases/etiology , Pemphigus/complications , Pemphigus/diagnosis , Aged , Cyclophosphamide/therapeutic use , Female , Glucocorticoids/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Nail Diseases/drug therapy , Pemphigus/drug therapy , Skin/pathology , Toes/pathologyABSTRACT
BACKGROUND: Atrophoderma vermiculatum is a rare, benign follicular disorder that primarily affects children. It is characterized by symmetric reticular or honeycomb atrophy of the cheeks that may extend to the ears and forehead. The defect is believed to be due to abnormal keratinization in the pilosebaceous follicle. Management of atrophoderma vermiculatum is challenging. MAIN OBSERVATIONS: We report the case of a 10-year-old boy, diagnosed as atrophoderma vermiculatum. The boy underwent two 6-month treatment courses with isotretinoin at a dose of 0.50mg/kg/day, which resulted in partial remission of the lesions. Even though the disease did not completely regressed, isotretinoin stopped atrophy progression and improved cosmetic appearance of the skin. CONCLUSIONS: In this case of a child with atrophoderma vermiculatum isotretinoin stopped atrophy progression and improved cosmetic appearance of the skin. No adverse events were observed. However, always, when applying isotretinoin in children, it has to be considered that, apart from possible common adverse events, this treatment may promote premature epiphyseal plate closure and may stop normal growth in some children.
ABSTRACT
Erythromelanosis follicularis faciei et colli (EFFC) is a rare disorder of unknown etiology characterized by the clinical triad of well-demarcated erythema, hyperpigmentation, and follicular plugging on the face. For many years, it was thought to be a disease occurring in males with ethnical cutaneous pigmentation. There are less than 50 cases reported in the literature, most of which are males. We describe bilateral EFFC in 2 females.
Subject(s)
Erythema/diagnosis , Facial Dermatoses/diagnosis , Melanosis/diagnosis , Adolescent , Adult , Erythema/pathology , Facial Dermatoses/pathology , Female , Humans , Melanosis/pathology , Skin/pathologyABSTRACT
We report a peculiar case of hemorrhagic pellagra in an exhausted Albanian refugee who had walked for 3 days under sunny skies on his way from his country to Greece. The peculiarities of the case are the fulminant course of the disorder; the "terrifying" appearance of the patient (initially he was admitted to an emergency unit); the gangrenous appearance of the hemorrhagic lesions of the palms and fingernails; the disturbed hepatic function that gradually returned to normal; and the absence of a history of alcohol consumption, alcohol malabsorption, or drug intake.
