Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review.

Cancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop. The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome-based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.

Valor predictivo del incremento de la presión arterial diastólica durante la prueba de esfuerzo en la cardiopatía isquémica / Predictive value of diastolic blood pressure during stress test of ischemic heart disease

Durante la prueba de esfuerzo (P/E) en el paciente isquémico coronario (IC), la presión arterial sistólica (TAS) asciende menos que en un grupo control de sujetos sanos (O), y es poco lo que se sabe del comportamiento de la presión arterial diastólica (TAD). Este trabajo estudia la diferencia entre la presión arterial diastólica (delta TAD) de reposo con la del máximo esfuerzo en siete grupos que se distribuyeron de acuerdo al número de vasos coronarios significativamente obstruidos o no. En 132 pacientes con (P/E) y coronariografía (C), de los cuales 116 eran IC y 16 O, se analizan los siguientes parámetros: XEdad (XE), Xdelta TAD, X2, valor de P, sensibilidad (S) especificidad (E), valor predictivo positivo (VP+), valor predictivo negativo (VP-). Se observó el comportamiento de la (TAD) en los casos con obstrucción arterial coronaria y se encontró que el ascenso de la Xdelta TAD en el 75% fue mayor de 15 mmHg. en el postesfuerzo inmediato que en reposo y de ellos el 86% tenía mala contractilidad en la ventriculografía izquierda. Se concluye que el incremento de la Xdelta TAD en el cardiópata isquémico tiene valor significativo en el análisis estadístico

[Predictive value of the increase in diastolic arterial pressure during the exercise test in ischemic cardiopathy]. / Valor predictivo del incremento de la presión arterial diastólica durante la prueba de esfuerzo en la cardiopatía isquémica.

There are few studies on the behavior of the diastolic blood pressure during the stress test. The purpose of this report is to present a simple, noninvasive technique of measuring the mean diastolic arterial blood pressure at rest, during maximal exercise testing and in the first minute of recovery (X delta DAP). We studied 132 patients with exercise testing (E/T) and coronariography (C). Of these, 116 had coronary artery disease and 16 did not. The following data were analyzed: Age (A) X delta DAP, X2, p value, sensitivity, specificity, positive predictive value (PV+), and negative predictive value (PV-). As we analyzed our patients with coronary arterial disease, we found that in 75% of the cases, the X delta DAP increased more than 15 mmHg, immediately after maximal effort, and 86% of these cases had poor myocardial contratility by angiocardiogram. We conclude that the increase of X delta DAP has a significant value in a ischemic heart disease.