ABSTRACT
Infections in burn patients are usually caused by multidrug-resistant micro-organisms. Tigecycline, a derivative of glycylcyclines, is an effective antibiotic against the resistant strains. The aim of this study is to determine the in vitro activity of tigecycline against the multidrug-resistant bacteria isolated from burn patients. Fourty-seven bacteria isolated from 118 patients hospitalized in the burn unit during 2003-2006 were included in the study. Gram-negative bacteria that were resistant to at least six broad-spectrum antibiotics, methicillin-resistant staphylococci and ampicillin-resistant enterococci were studied. Minimal inhibitory concentration values of tigecycline against these bacteria were tested by E-test strips. Susceptibility breakpoints were determined according to the previous studies; Subject(s)
Anti-Bacterial Agents/pharmacology
, Burns/microbiology
, Drug Resistance, Multiple, Bacterial
, Gram-Negative Bacteria/drug effects
, Minocycline/analogs & derivatives
, Acinetobacter/drug effects
, Bacteriological Techniques
, Burns/drug therapy
, Enterococcus/drug effects
, Gram-Negative Bacteria/isolation & purification
, Humans
, Methicillin Resistance/drug effects
, Microbial Sensitivity Tests
, Minocycline/pharmacology
, Staphylococcus aureus/drug effects
, Tigecycline