Identification of metastatic disease by T category, gleason score and serum PSA level in patients with carcinoma of the prostate.

Pre-operative serum prostate specific antigen (Tandem-R assay), T category, Gleason score and the metastatic (M1) status of a consecutive series of 60 patients with newly diagnosed carcinoma of the prostate were studied prospectively. The results revealed that, of these variables, pre-operative serum PSA (greater than 100 ng/ml) was the single most important indicator of metastatic disease, with 100% predictive value. With this alone, 83.3% of M1 disease could be correctly identified. For the remaining 17%, however, we advocate a high index of suspicion if the tumour is T3-T4 category on digital rectal examination (predictive value = 71.4%) and has a high grade with a Gleason score 8-10 (predictive value = 81%).

[Immunological state of reaction and healing of osteotomy (author's transl)]. / Immunologische Reaktionslage und Osteotomieheilung.

The influence of immune reaction on rats - achieved through C. F. A. - on the healing of incomplete osteotomy of the femur was experimentally examined. It was found that the production of immune reaction, manifested by the appearance of polyarthritis, leads in a great percentage (60% of the animals) in extensive bone destruction in the vicinity of the osteotomy. The results were examined clinically, radiologically and histologically. The type of reacton in the area of bone destruction was of immunological origin (histological examination).

[Bone reaction to metal and bone cement implants at immunologic reaction level in rats (author's transl)]. / Knochenreaktion auf Metall- und Knochenzement-Implantation bei immunologischer Reaktionslage, bei Ratten.

After the fact that femoral osteotomy in rats results in destruction of the entire bone (in the majority of experimental animals) due to an immunological reaction by means of Complete Freund's Adjuvant, we have investigated whether or not the implantation of bone cement or Kirschner wires affects additionally the condition of the bone. We have found that bone cement or metallic material within the bone cavity aggravates osteolysis if there is an immunologic reaction present. The conditions of the immunologic mechanism and the applied orthopedic procedures are discussed and an attempt has been made to explain the phenomenon.