ABSTRACT
Tumor cell lines and cultures are widely used in biomedical research. They are excellent model systems for analysis of oncological mechanisms and understanding the biology of tumor cells. Cell cultures are used to develop and test new anticancer drugs, radiosensitizers and radiotherapy methods. Clinical application of tumor cell cultures is directly related to development of personalized medicine. Using tumor cell culture in a particular patient, physicians can select treatment considering molecular genetic characteristics of patient and tumor. In addition, it is possible to choose the optimal drug or radiotherapy regimen with obvious effectiveness in certain cell culture. This review describes the advantages of such an approach.
Subject(s)
Cell Culture Techniques , Central Nervous System Neoplasms , Humans , Cell Culture Techniques/methods , Cell Line, TumorABSTRACT
Biobanks of central nervous system tumors are created in parallel with development of modern technologies for evaluation of molecular features of human diseases. In modern world practice, no one doubts that creation of biobanks of tumors is necessary and critical for personalized medicine. An important aspect of recent improvements in biobanks has been the expansion of tumor sample storage conditions. Development of cell technologies has made it possible to create cell cultures from tumor material that made it possible to evaluate further therapy before affecting the patient himself. Biobanks have become especially attractive in the study of brain tumors, where the peculiarity of location and blood-brain barrier complicate treatment approaches. This review describes the approaches to creation of biobanks of CNS tumors in world practice, sample storage conditions, ethical and legal regulation of biobanks, as well as experience of biobanking in different countries.
