ABSTRACT
There were studied 453 young servicemen with dyshormonal strain bone disease in whom the hormonal status, state of carbohydrate and protein metabolism were investigated. It was established that in 92.9% of patients the growth hormone--somatotropic hormone (STH) was significantly decreased, production of thyroid hormones necessary for physiologic osteogenesis (T3 and T4) was impaired and albuminous fraction dissociation was revealed. The authors consider that in dyshormonal strain bone disease in young people the insufficiency of hormonal regulation of growth processes and bone regeneration is the primary factor while the physical strain is the additional secondary factor.
Subject(s)
Bone Diseases, Metabolic/metabolism , Hormones/deficiency , Stress, Physiological/complications , Bone Diseases, Metabolic/etiology , Bone Regeneration , Bone Resorption/etiology , Fractures, Spontaneous/etiology , Fractures, Spontaneous/metabolism , Humans , Male , Military Personnel , OsteogenesisABSTRACT
A large variation of platelet serotonin content over short time intervals has been shown. This oscillation of platelet serotonin does not result from the accumulation of random technical variations, but can be considered as an objectively existing phenomenon which might be due to alternation of serotonin release and uptake processes in platelet-rich plasma. Sex and age do not influence the variation of platelet serotonin.
Subject(s)
Blood Platelets/chemistry , Serotonin/blood , Adult , Aging/blood , Female , Humans , Male , Middle Aged , Reference Values , Sex Characteristics , Time FactorsABSTRACT
The study of serotonin content in platelets showed the instability of this trait and its interrelation with plasma serotonin. The oscillations of platelet serotonin are stabilized by the removing of plasma proteins, calcium and by incubation with lithium. The model of synchronization of serotonin transport via the membrane of platelets bound into a spongy net by fibrinogen molecules is discussed.
Subject(s)
Blood Platelets/metabolism , Serotonin/blood , Biological Transport/physiology , Blood Platelets/drug effects , Blood Proteins/metabolism , Calcium/blood , Humans , Lithium/pharmacology , Reference ValuesSubject(s)
Sick Sinus Syndrome/diagnosis , Adolescent , Adult , Age Factors , Aged , Electrocardiography , Female , Humans , Male , Middle Aged , Sick Sinus Syndrome/etiology , Sick Sinus Syndrome/geneticsABSTRACT
The ascertainment of probands according to place of residence in hospitals or in the community has enabled our sampling to be representative of whole subpopulations of patients. Probands from psychiatric hospitals are characterized by biased clinical parameters. Our sampling procedure provides important preliminary results which appear to be contradictory to those produced by conventional sampling methods.
Subject(s)
Schizophrenia/epidemiology , Adolescent , Adult , Aged , Bias , Female , Humans , Male , Middle Aged , Prevalence , Sampling Studies , Schizophrenia/geneticsABSTRACT
The contribution of genetic, constitutional and environmental factors to the clinical polymorphism of schizophrenia was analysed. A sample from 353 pedigrees of the patients suffering from the manifest forms of schizophrenia which inhabited five districts of Tomsk region was studied using multifactorial threshold and single locus diallele models. It is established that the severity of the psychosis is mainly determined by autosomal genetic factors, the proportion of the affective disorders being specified by gonosomal factors. The type of the course of schizophrenia is closely connected with the patients' somatotype. Common environmental influences and peculiarities of personality before onset are linked with no characteristics of the clinical polymorphism studied.
Subject(s)
Polymorphism, Genetic/genetics , Schizophrenia/genetics , Environment , Humans , Models, Genetic , Phenotype , Russia/epidemiology , Schizophrenia/epidemiology , Schizotypal Personality Disorder/genetics , Somatotypes/geneticsABSTRACT
The program of genetic-epidemiological study of schizophrenia in five districts of the Tomsk region is presented. According to standardized methods, 610 diagnosed patients (epidemiological register) were examined, 74.1% of them being at random registered as probands (452 families of the epidemiological sample). 229 probands of non-epidemiological sample were registered in psychiatric hospitals. Schizophrenia occurrence parameters among first-degree relatives of probands of the non-epidemiological sample were regularly overestimated, as compared to the epidemiological sample. The methodical sources of contradictions in clinico-genealogical studies are discussed; the conclusion about representativeness+ of the probands' epidemiological sample is made.
Subject(s)
Schizophrenia/genetics , Humans , Sampling Studies , Schizophrenia/epidemiology , SiberiaABSTRACT
The results of studying the causes of prevalence and clinical polymorphism of schizophrenia on the basis of epidemiological selection of probands with paroxysmal-progredient form (211 families) have been presented in this paper. The analysis of multifactorial threshold and monolocus diallele models of factors of schizophrenia prevalence among relatives and in a population allowed to ground the hypothesis of the main gene. The characteristic manifestation is paroxysmal course of the process with small progredience and great specific weight of affective disorders. The increase of heterozygous genotype penetrance is linked to constitutional (somatotype, peculiarities of premorbid personality) and environmental (alcohol excesses, psychogenia) factors of probands.
Subject(s)
Genetic Variation , Models, Genetic , Schizophrenia/genetics , Alleles , Female , Genotype , Humans , Male , Pedigree , Schizophrenia/epidemiologyABSTRACT
Complex genetic-mathematical analysis (component decomposition of the phenotype variance, segregation analysis, estimation of penetrance parameters) of 324 probands' families with neurologic manifestation of spinal osteochondrosis (3437 relatives of I-III degree) has been carried out is shown that the structure of liability to the disease studied is better approximated by semi-continuous phenotype model within the limits of which contribution of genetic factors reaches 80% (63-66% owing to autosomes and 14-17% owing to gonosomes) under considerable influence (20%) of environmental force (14% accidental and 6% systematic).
Subject(s)
Nervous System Diseases/genetics , Osteochondritis/genetics , Spinal Diseases/genetics , Age Factors , Disease Susceptibility , Female , Gene Frequency , Genetics, Population , Humans , Male , Phenotype , Sex CharacteristicsABSTRACT
With the help of genetic-dispersion analysis the authors studied a series of phenotypes, using both their own familial records (232 families, 5060 relatives of the I-III degree of kinship) as well as those of other researchers (570 families, 18415 relatives of the I-III degree of kinship). The results have shown that the contribution of the genetic and environmental factors to the determination of epilepsy constitutes 5% and 95% in the alternative phenotype model and 65% and 35% in the quasi-continuous phenotype model, respectively. The degree of the genetic factors involvement in the development of phenotypes of "genuine" and "centroencephalic" epilepsy increases irrespective of the phenotype model. The authors also present their outlook on further developments of the genetic dispersion analysis in the research of multifactorial mental diseases.
