ABSTRACT
This study has simultaneously examined the kinetics of oxygen metabolism (KOM) and clinical symptoms of "pretoxemia" and edema of pregnancy. It was found out that estimates of KOM obtained before and after the hypoxia test may allow identification of abnormal tissue respiration typifying "pretoxemia", differentiation between "pretoxemia" and early-stage late toxemia (edema of pregnancy), and prediction of the risk and time of late toxemia, and potential of the body to adapt to hypoxia. Evaluation of KOM before and after the hypoxia test may be employed as a test for subclinical late toxemia.
Subject(s)
Blood Gas Monitoring, Transcutaneous , Pre-Eclampsia/blood , Blood Gas Monitoring, Transcutaneous/instrumentation , Diagnosis, Differential , Female , Humans , Nitrogen , Oxygen , Polarography/instrumentation , Pre-Eclampsia/diagnosis , Pregnancy , Pregnancy Trimester, Second , PrognosisABSTRACT
The authors studied the efficiency of preventive usage of intermittent normobaric hypoxic hypoxia (INHH) in 44 pregnant females at high risk for late gestosis in presence of essential hypertension, stages I-II, and hypertensive type of neurocirculatory asthenia. The authors paid attention to a decrease in the incidence of late gestosis, its severe patterns especially, and perinatal mortality.
Subject(s)
Hypoxia , Pre-Eclampsia/prevention & control , Adult , Atmospheric Pressure , Female , Humans , Infant, Newborn , Pre-Eclampsia/etiology , Pregnancy , Risk FactorsABSTRACT
Oxygen metabolism kinetics (OMK) was investigated in 90 pregnant females with high risk for late gestoses and associated vascular disorders (essential hypertension, stage I, and neurocirculatory asthenia of hyper- and hypotonic type) exposed to preventive treatment with intermitting normobaric hypoxia (INH). The study revealed that initial disorders of tissue respiration were featured with compensatory stimulation of tissue oxygen consumption. In early signs of late gestosis the consumption intensity was found to be diminished. During INH treatment course there was an evidence of normalization in oxygen metabolism. The time-course of OMK values permitted to assess the level of systemic adaptation to hypoxia in pregnancy. INH technique was proved to be an efficient nonpharmacological method of late gestosis prevention.
Subject(s)
Hypoxia/metabolism , Oxygen Consumption , Oxygen/administration & dosage , Pre-Eclampsia/prevention & control , Pregnancy/metabolism , Female , Humans , Oxygen/pharmacokinetics , Pre-Eclampsia/etiology , Pregnancy Trimester, Third , Risk FactorsABSTRACT
Therapeutic exposure to normobaric hypoxia improves both clinical and laboratory parameters in patients with chronic salpingo-oophoritis. The unidirectional trend of change is due to normalization of major systemic functions, including lymphocyte activity, owing to the recovery of lymphocyte metabolism and redistribution of T cell subpopulations towards a greater proportion of T helper cells. Adaptation to a moderate hypoxic stimulus is a promising physiologic method of improving nonspecific systemic reactivity.
Subject(s)
Nitrogen/administration & dosage , Oophoritis/immunology , Oxygen Inhalation Therapy , Oxygen/administration & dosage , Salpingitis/immunology , T-Lymphocytes/immunology , Adult , Chronic Disease , Female , Humans , Leukocyte Count , Lymphocyte Activation , Oophoritis/therapy , Rosette Formation , Salpingitis/therapySubject(s)
Adaptation, Physiological , Atmospheric Pressure , Hypoxia/physiopathology , Physical Endurance , Adaptation, Physiological/drug effects , Animals , Female , Humans , Male , Mice , Mice, Inbred BALB C , Neoplasms/physiopathology , Physical Endurance/drug effects , Physical Stimulation/methods , Rabbits , Rats , Rats, Inbred StrainsSubject(s)
Oophoritis/therapy , Oxygen Inhalation Therapy/methods , Salpingitis/therapy , Adult , Air Pressure , Chronic Disease , Evaluation Studies as Topic , Female , Humans , Nitrogen/administration & dosage , Nitrogen/therapeutic use , Oophoritis/complications , Oxygen/administration & dosage , Oxygen/therapeutic use , Salpingitis/complicationsSubject(s)
Immunity, Innate , Oxygen/pharmacology , Animals , Female , Humans , Male , Mice , Mice, Inbred BALB C , Rabbits , Rats , Rats, Inbred StrainsSubject(s)
Fetus/immunology , Immunity, Innate , Pregnancy, Animal , Adaptation, Physiological/drug effects , Animals , Animals, Newborn , Female , Fetal Hypoxia/immunology , Hypoxia/immunology , Immunity, Innate/drug effects , Nitrogen/pharmacology , Oxygen/pharmacology , Oxygen Consumption/drug effects , Partial Pressure , Pregnancy , Rabbits , Rats , Rats, Inbred Strains , Time FactorsSubject(s)
Pelvic Inflammatory Disease/blood , Adult , Female , Humans , Leukocyte Count , Menstrual CycleSubject(s)
Fetal Hypoxia/metabolism , Fetus/analysis , Oxygen/analysis , Uterus/analysis , Animals , Dogs , Female , Guinea Pigs , Partial Pressure , Pregnancy , RatsABSTRACT
Hypoxic cycles with a two fold reduction in PO2 levels (down to 51.7, 43.9 and 53.4%), the frequency of 0.63 +/- 0.07, 1.47 +/- 0.14, 1.98 +/- 0.3 per minute, and the duration of 45.4 +/ 2.9, 28.4 +/- 2.3 and 19.8 +/- 1.9 sec., respectively, were recorded during the measurement of oxygen content in the uterine tissue of pregnant (3-5 days) and non-pregnant rats, as well as in tissues of 13-14-day-old rat fetuses. The oxygen content remained unchanged throughout the whole experiment (30 min) in the peristaltic intestinal wall. The hypoxic cycles were assessed as a mechanism of rhythmic periodic stimulation of metabolic reactions directed towards not only the increased resistance to hypoxia but also towards non-specific resistance of uterine fetal tissues and female body in and out of pregnancy.
