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1.
Vet Surg ; 50(4): 807-815, 2021 May.
Article in English | MEDLINE | ID: mdl-33666268

ABSTRACT

OBJECTIVE: To determine the frequency of residual tumor, and factors associated with local recurrence and disease progression in dogs with incompletely excised mast cell tumors (MCT) following scar revision surgery. STUDY DESIGN: Retrospective study. ANIMALS: Eighty-five dogs. METHODS: Medical records from January 2000 to April 2013 were reviewed. Dogs with scar revision surgery after incomplete primary MCT excision were included. Recorded were signalment; initial tumor size, location and grade; time interval between primary excision and scar revision surgery; presence of MCT in the resected scar; local recurrence, lymph node metastasis, systemic metastasis, and cause of death. RESULTS: Eighty six tumors in 85 dogs were studied. Residual MCT was found in 23 (27%) resected scars. Seven (8%) scars with residual MCT had incomplete or narrow margins. Follow-up was available for 68 dogs (69 tumors; median 403 days; range 4-2939). Local recurrence was reported in three (4%) dogs at 212, 555, and 993 days. Disease progressed in 10 dogs (14.5%) with regional or systemic metastasis at a median of 207 days (64-1583). Margin status and presence of MCT in the resected scar were not associated with local recurrence or disease progression. Lymph node metastasis (p = .004), locoregional recurrence (p = .013), and disease progression (p = .001) were significantly more likely in Grade III tumors. CONCLUSION: Twenty-seven percent of resected scars contained residual MCT, but recurrence was uncommon after surgical revision. CLINICAL SIGNIFICANCE: Clinicians should primarily consider tumor grade when estimating the likelihood of local recurrence and disease progression and determining the need for ancillary treatment of MCT after scar resection.


Subject(s)
Cicatrix/veterinary , Dog Diseases/surgery , Neoplasm Recurrence, Local/veterinary , Reoperation/veterinary , Skin Neoplasms/veterinary , Animals , Cicatrix/surgery , Dogs , Female , Male , Margins of Excision , Mast Cells/pathology , Neoplasm Recurrence, Local/surgery , Neoplasm, Residual/veterinary , Reoperation/statistics & numerical data , Retrospective Studies , Skin Neoplasms/classification , Skin Neoplasms/pathology , Treatment Outcome
2.
Vet Surg ; 41(1): 20-33, 2012 Jan.
Article in English | MEDLINE | ID: mdl-23253036

ABSTRACT

OBJECTIVE: To determine the chronology of radiographic signs of canine hip dysplasia (CHD), specifically joint laxity and secondary osteoarthritis (OA). STUDY DESIGN: Longitudinal cohort study. ANIMALS: Paired littermates, 48 Labrador retrievers. METHODS: Conventional, ventrodorsal, hip-extended (HE) radiographs were evaluated yearly for CHD according to the subjective criteria of the Orthopedic Foundation for Animals (OFA). PennHIP screening was performed at 2 years of age to assess joint laxity by distraction index (DI). Histopathologic evaluation of coxofemoral joints was performed at the dogs' natural end of life. RESULTS: Coxofemoral subluxation, as identified on the HE radiograph occurred by 2 years of age and not thereafter. Accuracy of OFA-criteria scoring was poor: 55% of dogs scored "normal" at 2 years of age became radiographically dysplastic by the end of life (45% negative predictive value, NPV); 92% of the dogs scored as normal at 2 years of age had histopathologic OA of CHD (8% NPV). The DI predicted all 48 dogs to be susceptible to OA of CHD and 98% had radiographic or histopathologic OA by the end of life. CONCLUSION: OFA-criteria score was profoundly influenced by environmental factors, such as diet restriction and age, reducing its value as a selection criterion. DI measurements were not influenced by dietary treatment suggesting higher trait heritability.


Subject(s)
Hip Dysplasia, Canine/pathology , Animals , Cohort Studies , Dogs , Female , Hip Joint/pathology , Longevity , Male , Osteoarthritis, Hip/pathology , Osteoarthritis, Hip/veterinary
3.
Vet Surg ; 41(1): 34-41, 2012 Jan.
Article in English | MEDLINE | ID: mdl-23253037

ABSTRACT

OBJECTIVE: To investigate the radiographic hip joint phenotype of the Pembroke Welsh Corgi. STUDY DESIGN: Prospective and retrospective cross-sectional study. ANIMALS: Pembroke Welsh Corgis (n = 399). METHODS: Ventrodorsal, hip-extended radiographs were evaluated for subluxation, osteoarthritis (OA), caudolateral curvilinear osteophytes (CCO), and circumferential femoral head osteophytes (CFHO) of PennHIP evaluated Corgis. Joint laxity was measured by distraction index (DI). RESULTS: All Corgis had DI > 0.30 (mean, 0.66), 6.8% had OA, 18% had subluxation, 22.3% had CCO, and 74.4% had CFHO. Higher DI increased the odds for subluxation and canine hip dysplasia (CHD) but not for OA, CCO, or CFHO. The presence of CCO increased the odds for OA by 4.6 times (P = .002) and 2.2 times (P = .01) for hip dysplasia. All dogs with OA had CFHO. The presence of CFHO increased the odds for subluxation by 8.7 times (p < .001) and 8.9 times (P < .001) for hip dysplasia. Subluxation increased the odds for OA by 15.4 times (P < .001). CONCLUSION: Corgis had a low frequency of conventional OA despite having hip laxity that has been shown to correlate with hip OA and hip dysplasia in large-breed dogs. The relationship between CCO and OA was similar to published findings in nonchondrodystrophic large-breed dogs and the CFHO was significantly associated with subluxation. Both CCO and CFHO are associated with hip dysplasia in this small chondrodystrophic breed.


Subject(s)
Hip Joint/diagnostic imaging , Aging , Animals , Cross-Sectional Studies , Dog Diseases/diagnostic imaging , Dog Diseases/pathology , Dogs , Female , Hip Joint/pathology , Logistic Models , Male , Osteoarthritis, Hip/diagnostic imaging , Osteoarthritis, Hip/pathology , Osteoarthritis, Hip/veterinary , Radiography
4.
J Am Vet Med Assoc ; 237(5): 532-41, 2010 Sep 01.
Article in English | MEDLINE | ID: mdl-20807130

ABSTRACT

OBJECTIVE: To compare 2 screening methods for detecting evidence of hip dysplasia (Orthopedic Foundation for Animals [OFA] and PennHIP) in dogs. DESIGN: Diagnostic test evaluation study. Animals-439 dogs >or= 24 months of age that received routine hip joint screening from June 1987 through July 2008. PROCEDURES: Dogs were sedated, and PennHIP radiography was performed (hip joint- extended [HE], compression, and distraction radiographic views). The HE radiographic view was submitted for OFA evaluation. A copy of the HE radiographic view plus the compression and distraction radiographic views were submitted for routine PennHIP evaluation, including quantification of hip joint laxity via the distraction index (DI). RESULTS: 14% (60/439) of dogs had hip joints scored as excellent by OFA standards; however, 52% (31/60) of those had a DI >or= 0.30 (range, 0.14 to 0.61). Eighty-two percent of (183/223) dogs with OFA-rated good hip joints had a DI >or= 0.30 (range, 0.10 to 0.77), and 94% (79/84) of dogs with OFA-rated fair hip joints had a DI >or= 0.30 (range, 0.14 to 0.77). Of all dogs with fair to excellent hip joints by OFA standards, 80% (293/367) had a DI >or= 0.30. All dogs with OFA-rated borderline hip joints or mild, moderate, or severe hip dysplasia had a DI >or= 0.30 (range, 0.30 to 0.83). CONCLUSION AND CLINICAL RELEVANCE: Dogs judged as phenotypically normal by the OFA harbored clinically important passive hip joint laxity as determined via distraction radiography. Results suggested that OFA scoring of HE radiographs underestimated susceptibility to osteoarthritis in dogs, which may impede progress in reducing or eliminating hip dysplasia through breeding.


Subject(s)
Dog Diseases/diagnostic imaging , Hip Dysplasia, Canine/diagnostic imaging , Animals , Dog Diseases/classification , Dogs , Hip Dysplasia, Canine/classification , Joint Instability/classification , Joint Instability/diagnostic imaging , Joint Instability/veterinary , Orthopedics/organization & administration , Orthopedics/standards , Orthopedics/veterinary , Radiography/standards , Radiography/veterinary , United States
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