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1.
Khirurgiia (Mosk) ; (9): 89-91, 2020.
Article in Russian | MEDLINE | ID: mdl-33030008

ABSTRACT

Low-grade mucinous tumors (MT) of the appendix are rare malignancies. One of the most formidable complications of these tumors is mucin depositing in the peritoneum with development of peritoneal pseudomyxoma. Currently, there are no single clinical - pathomorphological classification and treatment approach to these tumors. This situation is complicated by the fact that tumor of the appendix cannot be preoperatively suspected in many cases and MT is detected after appendectomy for acute appendicitis or its complications. Thus, prognosis of patients is deteriorated.


Subject(s)
Appendiceal Neoplasms , Appendix , Appendectomy , Appendicitis , Humans , Peritoneal Neoplasms
2.
J Trauma ; 47(4): 691-8, 1999 Oct.
Article in English | MEDLINE | ID: mdl-10528603

ABSTRACT

OBJECTIVES: Cardiovascular, respiratory, and vascular dysfunction can follow trauma-induced no-flow-reflow states: hemorrhage, blunt trauma, or neurogenic shock. Liver ischemia-reperfusion (IR) induces remote lung damage by means of xanthine oxidase (XO) pro-oxidant activity. This damage was not proven in the heart, neither was the independent role of radical oxygen species (ROS) established in such cases. We investigated whether multiple organ dysfunction after a trauma-like IR is XO and ROS related and whether clinically used ROS scavengers could be beneficial. METHODS: A controlled, randomized trial in which isolated rat livers, hearts, lungs, and aortic rings were perfused with Krebs-Henseleit solutions. After stabilization, livers were either perfused or made ischemic (2 hours). Then, pairs of liver plus heart, lung, or ring were reperfused in series (15 minutes), and then the second organ circulated alone for 45 minutes. Remote organ protection against the pro-oxidant hepatic-induced toxicity was evaluated by using allopurinol (1 mmol/L, heart), mannitol (0.25 g/kg, lung), or methylene blue (40 mg/kg, ring). RESULTS: IR liver effluents typically contained high lactate dehydrogenase, XO, and uric acid concentrations compared with control organs. IR was associated with doubled lung peak inspiratory pressure and reduced static compliance. Myocardial velocity of contraction and relaxation decreased by one third of baseline, and rings contracted abnormally and responded inadequately to phenylephrine. Wet-weight to dry-weight ratios in the remote organs increased as well. Most remote reperfusion injuries were attenuated by the drugs. CONCLUSION: Liver no-flow-reflow directly induces myocardial, pulmonary, and vascular dysfunction. These are likely mediated by XO and ROS. The tested drugs protected against these pro-oxidants, even in the presence of circulating XO.


Subject(s)
Aorta/metabolism , Heart Arrest/complications , Liver/metabolism , Lung/metabolism , Multiple Organ Failure/etiology , Multiple Organ Failure/metabolism , Multiple Trauma/complications , Myocardium/metabolism , Reactive Oxygen Species/metabolism , Reperfusion Injury/etiology , Reperfusion Injury/metabolism , Xanthine Oxidase/metabolism , Allopurinol/therapeutic use , Animals , Coronary Vessels , Disease Models, Animal , Drug Evaluation, Preclinical , Free Radical Scavengers/therapeutic use , In Vitro Techniques , Liver/blood supply , Lung/blood supply , Male , Mannitol/therapeutic use , Methylene Blue/therapeutic use , Multiple Organ Failure/drug therapy , Random Allocation , Rats , Rats, Wistar , Reperfusion Injury/drug therapy , Xanthine Oxidase/antagonists & inhibitors
3.
J Trauma ; 43(4): 627-33; discussion 633-5, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9356059

ABSTRACT

OBJECTIVES: To investigate whether liver ischemia and reperfusion (IR) directly affect functions of remote organs. BACKGROUND: Cardiovascular and respiratory dysfunction follows hemorrhage, spinal shock, or trauma as a result of no-flow-reflow phenomena. Hepatic IR induces remote organ damage probably by xanthine oxidase and oxygen species. MATERIALS AND METHODS: Isolated rat livers, lungs, and hearts were perfused with Krebs-Henseleit solutions. After stabilization, livers were either perfused or made ischemic. Then, livers and hearts or livers and lungs were reperfused in series, and the liver was disconnected and the second organ continued to perfuse with the accumulated effluents. MEASUREMENTS AND MAIN RESULTS: Ischemic and reperfused liver effluent contained high lactate dehydrogenase and uric acid concentrations compared with controls; xanthine oxidase increased 60 to 100 times. Ischemic and reperfused lung peak inspiratory pressure almost doubled; airway static compliance halved; myocardial contractility decreased to 70% of baseline; wet weight-to-dry weight ratios of lungs and livers increased. CONCLUSION: Ischemic and reperfused liver can directly induce myocardial and pulmonary dysfunction, presumably by oxidant-induced injury.


Subject(s)
Heart Diseases/etiology , Liver/blood supply , Lung Diseases/etiology , Reperfusion Injury/complications , Acute Disease , Animals , Heart Diseases/physiopathology , In Vitro Techniques , L-Lactate Dehydrogenase/metabolism , Liver/metabolism , Lung Diseases/physiopathology , Male , Myocardial Contraction , Rats , Rats, Wistar , Reperfusion Injury/physiopathology , Uric Acid/metabolism , Xanthine Oxidase/metabolism
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