[Pathogenetic role of disorders of cholesterol metabolism in erythrocyte membranes in patients with exertion-induced angina pectoris]. / Patogeneticheskaia rol' narushenii metabolizma kholesterina v membranakh éritrotsitov u bol'nykh so stenokardiei napriazheniia.

A total of 90 working-age patients suffering from exercise-induced angina were examined. As the disease progressed, there was an inhibition of cholesterol esterification processes and an accumulation of dehydrocholesterol in the lipid bilayer of red blood cell membranes. The severity of coronary atherosclerosis evidenced by multi-position selective coronary angiography was found to show a significantly positive correlation with dehydrocholesterol levels and a negative correlation with the cholesterol/cholesterol ester ratio in the membranes of red blood cells. The use of finoptin in a daily dose of 320 mg in patients with exercise-induced angina diminished the magnitude of the potentially atherogenic alterations observed in cholesterol metabolism in the cell membranes.

[Significance of changes in phospholipid condition of cell membranes in the development of tolerance to long-acting nitrates in patients with exercise-induced angina pectoris]. / Znachenie izmenenii fosfolipidnogo sostava kletochnykh membran v razvitii tolerantnosti k prolongirovannym nitratam u bol'nykh so stenokardiei napriazheniia.

Sixty one patients with exercise-induced angina were examined. The development of sustac forte tolerance was found to be related to lower levels of phosphatidylserine and phosphatidylethanolamine in erythrocyte membranes. The changes in the phospholipid composition of cell membranes were demonstrated to be largely caused by the effects of prolonged nitrates themselves. Essential given to patients with exercise-induced angina who were tolerant to the nitrates elevated the levels of phosphatidylserine and phosphatidylethanolamine in the erythrocyte membranes, which was accompanied in most cases by higher exercise tolerance as evidenced by a repeated bicycle ergometric test when the same dose of sustac forte was used. This allows the authors to recommend to use essential to abolish prolonged nitrate tolerance.

[A clinico-pathogenetic assessment of the membrane structure and functions of the peripheral blood lymphocytes in insulin-dependent diabetes mellitus]. / Kliniko-patogeneticheskaia otsenka struktury i funktsii membran limfotsitov perifericheskoi krovi pri insulinzavisimom sakharnom diabete.

The structure and functions of lymphocyte membranes with characterization of their phospholipid composition, lipid peroxidation intensity (LP), activity of membranous ATPases and a type of the immune status were investigated in patients with insulin dependent diabetes mellitus. The results obtained were indicative of considerable differences (LP) in the lymphocytes of these patients as compared to those of healthy controls. LP intensity showed correlation with change in the ratio of phospholipid fractions and change in ATPase activity. In complicated insulin dependent diabetes mellitus destabilization of lymphocyte cell membranes and disturbance of transmembranous transport were more marked than in uncomplicated disease. The structure and functions of the membranes of immunocompetent cells, a degree of carbohydrate metabolic decompensation and the presence of complications determined an immune response type.

[Opisthorchiasis, the pancreas and diabetes mellitus]. / Opistorkhoz, podzheludochnaia zheleza, sakharnyi diabet.

The authors reviewed the data on pathogenesis, pathomorphology and clinical appearance of the incretory pancreatic involvement in opisthorchiasis patients. Besides, the authors presented their own data on the impact of opisthorchiasis invasion on the formation of diabetes mellitus. The concept of a diphasic involvement of the insular system was considered.

[Membrane-protective effect of finoptin in exertion-induced stenocardia]. / Membranoprotektornyi éffekt finoptina pri stenokardii napriazheniia.

Ninety five males of employable age who suffered from effort-associated angina were examined. As the severity of angina increased, the structural disorganization of the lipid bilayer progressed in the erythrocyte membranes, resulting in abnormal functional status of Na+,K+- and Ca2+-ATPases and in accumulation of Ca2+ and Na in the intracellular space, by lowering potassium levels. Finoptin given to patients with angina not only diminished intracellular calcium concentrations, but produced membrane-protective effects by lowering malonic dialdehyde levels in the lipid bilayer of the cellular membranes, by accumulating phospholipids and cholesterol esters, and returning the values of Na+,K+- and Ca2+-ATPase activities to controls. A parallelism was found between the magnitude of the membrane-protective action of finoptin in patients with angina and its antianginal effect.

[Dynamics of lipid metabolism in the combined treatment of alimentary obesity]. / Dinamika lipidnogo obmena pri kompleksnom lechenii alimentarnogo ozhireniia.

A total of 128 patients with alimentary obesity were examined in the course of the treatment. There was a significant elevation in blood serum of total and free cholesterol, its esters, free fatty acids, beta-lipoproteins, and a decrease in the activity of serum lipase. The correlation of cholesterol esters to phospholipids was found to be disordered. Eighty patients demonstrated, after treatment with chloride sodium bromoiodine baths combined with hypocaloric diet and exercise therapy, a favourable clinical time course and normalization of the majority of lipid metabolism indicators, with an increase in serum lipase activity. Twenty-five patients, who received fresh baths under similar conditions, demonstrated less pronounced shifts in lipid metabolism, which were not always significant. The treatment complex including phepranon also gave rise to the normalization of the majority of lipid metabolism indicators. However, one-third of cases developed serious side effects.