ABSTRACT
The aim of this study was to investigate the effect of unilateral nephrectomy on the pharmacokinetics of gentamicin. The study was carried out on 19 male rabbits. Gentamicin was injected i.v. at a dose of 3.5 mg/kg twice daily during 5 days, before operation and after 2 weeks as well as 3 months from nephrectomy. Blood for the assays was collected within 6 hours after the drug administration on the 5th day of each study stage. The immunofluorescence polarization method was employed for determination of gentamicin concentration. The one-compartment open model was used for calculations. It was shown that in unilaterally nephrectomized rabbits the elimination of gentamicin can be significantly impaired during the whole study period.
Subject(s)
Gentamicins/pharmacokinetics , Nephrectomy , Animals , Gentamicins/administration & dosage , Male , RabbitsABSTRACT
The pharmacokinetics of salicylate was investigated in rabbits 6 months after unilateral nephrectomy. Sodium salicylate was given through the stomach gauge once in a dose of 20 mg/kg. Pharmacokinetic calculations assuming one compartment open model have revealed that in nephrectomized rabbits area under the curve (AUC) was increased by 131%, t0.5 was prolonged from 4.46 to 5.78 h, and kel was diminished by 40%. The plasma creatinine level remained unchanged and the remaining kidney was increased by 68%.
Subject(s)
Nephrectomy , Salicylates/metabolism , Animals , Creatinine/blood , Female , Kinetics , Male , RabbitsABSTRACT
An analysis of the single-dose pharmacokinetics of rolitetracycline in rabbits after unilateral nephrectomy is presented. Rolitetracycline was injected i.v. 3.5 mg/kg before operation and after 2 weeks, 3 months and 6 months from unilateral nephroctomy. The concentration of the antibiotic in plasma was estimated by the fluorimetric method of Kohn. The two-compartment open model was applied to calculate rolitetracycline concentration changes. The calculations of pharmacokinetic parameters were performed using the Hewlett-Packard 9830B computer and fitting the concentrations of the antibiotic in blood to the general biexponential equation. AUC of rolitetracycline was increased in operated animals by 130% after 6 months. The mean kel at this time decreased, while t0.5 beta was prolonged from 1.0 h to 3.0 h. It is assumed that the dosage regimen of rolitetracycline should be changed in subjects possessing one kidney.
