"It turned out right for both of us": A qualitative study about a preference for home death and actual place of death.

This qualitative study was conducted in Norway to explore couples' preference for home death when one of the partners was dying from cancer, and what made home death possible or not. We conducted dyad interviews with five couples. After the patients' death, the spouses participated in individual interviews. The data were interpreted using thematic narrative analysis. One patient died at home, and three died in a healthcare institution. The narratives show how interdependency and mutual care were important when dealing with home death. When care needs were manageable at home, home was perceived a safe place and the preferred place for death. When care needs were experienced to become unmanageable at home, the sense of safety changed and admission to a health care institution was considered the best option. Regardless of place of death, the spouses experienced the end to have turned out right for their partner and themselves.

A randomized controlled trial examining the effect of camp HOPE Tennessee on youth functioning: Results from a pilot study.

OBJECTIVE: Family violence can negatively affect youth's psychosocial functioning. Strengths-based interventions may enhance positive youth functioning among youth experiencing adversity, but little is known about the effectiveness of camp-based interventions for youth exposed to family violence. The current study examined the effectiveness of Camp HOPE Tennessee in promoting multidimensional well-being and school engagement among youth exposed to family violence. METHOD: This pilot study employed a nonmasked, parallel randomized controlled design. Participants were 47 children and their caregivers who sought services from a Family Justice Center. Children were 7-12 years old (M = 9.55, SD = 1.63; 79% Black/African American). Using block randomization, caregiver-child dyads were assigned to the camp (n = 23) or waitlist control (n = 24) condition and completed evaluations at baseline, 2-month follow-up, and 5-month follow-up. Children reported on two indicators of positive functioning: multidimensional Quality of Life (i.e., Physical Well-Being, Psychological Well-Being, Autonomy And Parent Relations, Social Support And Peers, And School Environment) and School Engagement. Piecewise latent growth curve models evaluated between-group differences in positive youth functioning at 2- and 5-month follow-up (ClinicalTrials.gov: CampHopeTN). RESULTS: Results suggest that Camp HOPE positively impacted children's psychological well-being (difference = 12.28, SE = 2.84, p < .001, g = 0.94) and autonomy and parent relations (difference = 7.96, SE = 2.95, p = .007, g = 0.77) at 2-month follow-up. Additionally, the camp appeared to have a long-term effect on school engagement at 5-month follow-up (difference = 9.97, SE = 4.83, p = .039, g = 0.59). CONCLUSIONS: Results suggest that camp interventions may enhance positive functioning among youth exposed to family violence. Larger investigations are needed to strengthen the evidence base for Camp HOPE's effectiveness and support further dissemination. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Expectations related to home-based telemonitoring of high-risk pregnancies: A qualitative study addressing healthcare providers' and users' views in Norway.

INTRODUCTION: A pregnancy can be evaluated as high-risk for the woman and/or the fetus based on medical history and on previous or ongoing pregnancy characteristics. Monitoring high-risk pregnancies is crucial for early detection of alarming features, enabling timely intervention to ensure optimal maternal and fetal health outcomes. Home-based telemonitoring (HBTM) is a marginally exploited opportunity in antenatal care. The aim of this study was to illuminate healthcare providers' and users' expectations and views about HBTM of maternal and fetal health in high-risk pregnancies before implementation. MATERIAL AND METHODS: To address diverse perspectives regarding HBTM of high-risk pregnancies, four different groups of experienced healthcare providers or users were interviewed (n = 21). Focus group interviews were conducted separately with midwives, obstetricians, and women who had previously experienced stillbirth. Six individual interviews were conducted with hospitalized women with ongoing high-risk pregnancies, representing potential candidates for HBTM. None of the participants had any previous experience with HBTM of pregnancies. The study is embedded in a social constructivist research paradigm. Interviews were analyzed using a thematic approach. RESULTS: The participants acknowledged the benefits and potentials of more active roles for both care recipients and providers in HBTM. Concerns were clearly addressed and articulated in the following themes: eligibility and ability of women, availability of midwives and obstetricians, empowerment and patient safety, and shared responsibility. All groups problematized issues crucial to maintaining a sense of safety for care recipients, and healthcare providers also addressed issues related to maintaining a sense of safety also for the care providers. Conditions for HBTM were understood in terms of optimal personalized training, individual assessment of eligibility, and empowerment of an active patient role. These conditions were linked to the importance of competent and experienced midwives and obstetricians operating the monitoring, as well as the availability and continuity of care provision. Maintenance of safety in HBTM in high-risk pregnancies was crucial, particularly so in situations involving emerging acute health issues. CONCLUSIONS: HBTM requires new, proactive roles among midwives, obstetricians, and monitored women, introducing a fine-tuned balance between personalized and standardized care to provide safe, optimal monitoring of high-risk pregnancies.

Examining Early Childhood Dimensions of Emotional Awareness Using a Novel Coloring Task.

Emotional awareness supports emotion regulation. Psychologists have children "color in feelings" to assess emotional awareness, yet whether this relates to emotion regulation is unknown. The present study used a novel coloring task examining behaviors related to coloring in and dictating emotions to assess children's (N=95) emotional awareness. Further, it was tested whether performance on this task predicted emotion regulation. Children's coloring behaviors indicating physiological emotional awareness predicted better emotion regulation. Results may inform the use of emotional awareness tasks in community and clinical settings. Findings also suggest that physiological emotional awareness may be a more salient clinical target in children.

'It's not just about me': a qualitative study of couples' narratives about home death when one of the partners is dying of cancer.

Background: Most cancer patients state a preference for home death. Care and support from primary caregivers are important to enable dying at home. A preference for home death from the perspective of couples has rarely been investigated. Objectives: To explore how a preference for home death is understood and enacted in couples where one of the partners is dying of cancer. Design: A qualitative interview research design with a narrative approach was used. Methods: Five couples participated in dyad interviews. During the analysis, two interviews that particularly illuminated couples' shared and individual views were chosen as the primary cases. Results: The interviews show, in two highly different ways, how a preference for home death is a significant relational matter. The interviews are presented as two cases: 'Struggles in an Unknown Terrain' and 'Reliance at the Kitchen Table'. They show how a preference for home death can be understood and enacted as a struggle or as reliance based on the couple's shared biography and the partner's ability to care for the partner during the end-of-life phase. The analysis highlighted the negotiations that underpin a preference for home death. In these negotiations, the couples drew on idealised understandings of home death. These ideas were supported by cultural values related to autonomy and independence as well as participation and citizenship. Thus, in the negotiations about being cared for and caring, legitimate dependency and the maintenance of a reciprocal relationship were balanced. The presence of healthcare professionals and medical devices in the home had to be balanced with the need to maintain a sense of self and an authentic home. Conclusion: A relational perspective on a preference for home death made us attentive to couples' negotiations. These negotiations give couples the opportunity to re-evaluate and reconfirm individual and mutual needs in the end-of-life phase.

Unpacking the Lay Epidemiology of Cervical Cancer: A Focus Group Study on the Perceptions of Cervical Cancer and Its Prevention among Women Late for Screening in Norway.

Nonattendance for cervical cancer screening is often understood in terms of a lack of 'appropriate' or 'correct' knowledge about the risks and prevention of the disease. Few studies have explored how lay persons-the users themselves-interpret and contextualise scientific knowledge about cervical cancer. In this study, we address the following research question: How is the epidemiology of cervical cancer and its prevention discussed among women who are late for cervical cancer screening in Norway? We completed nine focus group interviews (FGIs) with 41 women who had postponed cervical screening. The analyses were both inductive and explorative, aiming to unpack the complexity of lay understandings of cervical cancer. Interactive associations expressed in the FGIs reflected multiple understandings of aetiology and risk factors, screening, and interpretations of responsibility for acquiring cervical cancer. The term 'candidacy' was employed to provide an enhanced understanding of lay reasoning about the explanations and predictions of cervical cancer, as reflected in the FGIs. Both interpretations of biomedical concepts and cultural values were used to negotiate acceptable and nuanced interpretations of candidacy for cervical cancer. Uncertainties about risk factors for acquiring cervical cancer was an important aspect of such negotiations. The study's findings provide an in-depth understanding of the contexts in which screening may be rendered less relevant or significant for maintaining health. Lay epidemiology should not be considered inappropriate knowledge but rather as a productive component when understanding health behaviours, such as screening attendance.

Mapping Individual, Relational, and Contextual Factors onto Posttraumatic Stress Symptoms and Resilience.

Posttraumatic stress symptoms (PTSS) and resilience are two well-established outcomes following trauma exposure, but little work has examined the unique associations between these outcomes and factors across the social ecology. This theoretically grounded study assessed how individual, relational, and contextual social ecological factors relate to PTSS and resilience. Participants included 606 college students (18-25 years, Mage = 20.79, SD = 1.86; 82.51% Female; 56.60% White, 29.37% Black or African American, 5.78% Asian, 8.25% Other races) with exposure to at least one traumatic event. Two hierarchical linear regression models examined associations between individual (i.e., emotion dysregulation, anger severity), relational (i.e., family support, friend support), and contextual (i.e., community cohesion, community disorder) factors, and PTSS and resilience. At the individual level, higher emotion dysregulation was associated with higher PTSS and lower resilience; anger severity was not related to either outcome. At the relational level, more friend support was negatively associated with PTSS. Friend and family support were positively related to resilience. At the contextual level, community cohesion was positively associated with resilience, but not PTSS, and community disorder was unrelated to both outcomes. Findings demonstrate unique factors across the social ecology that differentially relate to PTSS and resilience. Variables at all three ecological levels were associated with resilience, whereas only individual and relational variables were related to PTSS. Replication with longitudinal data could inform treatments for trauma-exposed individuals that may mitigate PTSS and bolster resilience.

The Role of Dimensions of Emotion Dysregulation Following Exposure to Maltreatment and Adult Victimization.

Child maltreatment is related to a host of negative consequences, including difficulties with emotion regulation (ER), posttraumatic stress symptoms (PTSS), and greater risk for revictimization. Yet, the literature has largely focused on sexual revictimization, while relations between maltreatment and other adult victimization types (e.g., intimate partner violence [IPV]) are less clear. Further, associations between emotion dysregulation and both child and adult trauma exposure have been identified, but aspects of dysregulation (i.e., nonacceptance of emotional responses, difficulties engaging in goal-directed behavior, impulsivity, lack of emotional awareness, limited access to ER strategies, and lack of emotional clarity) have received less attention. This study aimed to: (1) investigate the associations between maltreatment and adult victimization and the six ER dimensions while accounting for PTSS, and (2) determine whether there are indirect effects between maltreatment and adult victimization through each ER component. Seven hundred and forty-four undergraduates from two universities participated in the study (Mage = 21.48, SD = 4.12; 80.9% women; 56.2% white). Maltreatment and PTSS were directly linked with adult victimization (B = 0.14, B = 0.01, respectively). PTSS was inversely associated with each ER aspect (Bs = 0.02-0.10). Unexpectedly, neither maltreatment nor adult victimization was related to the ER dimensions, and no indirect effects were observed between maltreatment and adult victimization through emotion dysregulation. These findings suggest that specific components of emotion dysregulation may not be tied to trauma exposure outside of PTSS. Further, it may be that the ER dimensions are not differentially related to increased risk for adult victimization.

Evaluation of taste active peptides and amino acids from anchovy proteins in fish sauce by in silico approach.

Enzymatic activity and microbial fermentation play a prominent role in the bioconversion of complex muscle tissue into smaller units of peptides and amino acids, possibly contribute to sensory properties. Thus, this study screens and evaluate anchovy proteins with taste-active peptides and amino acids by the reaction of multiple enzymes using an in silico approach. Information about sensory components was provided based on an in silico analysis using tools available in the BIOPEP-UWM database. Proteins from anchovy, namely myosin heavy chain 6 alpha, myosin light chain 1, cytochrome B, and NADH ubiquinone oxidoreductase, were subjected to in silico digestion with the combination of 23 enzymes. This led to the release of taste-active peptides and amino acids, including umami, sweet, salty, sour, and bitter sensory properties. The combination of multiple enzymes released a more significant number of taste-active peptides and amino acids for both myosins compared to other proteins.

Prefrontal modulation of frustration-related physiology in preschool children ranging from low to severe irritability.

Limbic-prefrontal connectivity during negative emotional challenges underpins a wide range of psychiatric disorders, yet the early development of this system is largely unknown due to difficulties imaging young children. Functional Near-Infrared Spectroscopy (fNIRS) has advanced an understanding of early emotion-related prefrontal activation and psychopathology, but cannot detect activation below the outer cortex. Galvanic skin response (GSR) is a sensitive index of autonomic arousal strongly influenced by numerous limbic structures. We recorded simultaneous lateral prefrontal cortex (lPFC) activation via fNIRS and GSR in 73 3- to 5-year-old children, who ranged from low to severe levels of irritability, during a frustration task. The goal of the study was to test how frustration-related PFC activation modulated psychophysiology in preschool children, and whether associations were moderated by irritability severity. Results showed lPFC activation significantly increased, and GSR levels significantly decreased, as children moved from frustration to rest, such that preschoolers with the highest activation had the steepest recovery. Further, this relation was moderated by irritability such that children with severe irritability showed no association between lPFC activation and GSR. Results suggest functional connections between prefrontal and autonomic nervous systems are in place early in life, with evidence of lPFC down-regulation of frustration-based stress that is altered in early psychopathology. Combining fNIRS and GSR may be a promising novel approach for inferring limbic-PFC processes that drive early emotion regulation and psychopathology.

Benefits and Drawbacks of Police Integration Into Assertive Community Treatment Teams.

OBJECTIVE: Assertive community treatment (ACT) teams provide outreach services to individuals coping with severe mental illness. Because such individuals are at increased risk for involvement with law enforcement, a model that integrates police officers into ACT teams (ACT-PI) was developed for ACT teams serving clients with or without forensic involvement. The goal of this study, conducted in British Columbia, was to evaluate the benefits and drawbacks of the ACT-PI model. METHODS: Qualitative semistructured interviews were conducted with 21 ACT-PI clients (in 2017) and 22 ACT-PI staff (in 2018). Thematic analyses identified key themes related to the benefits and drawbacks of officer integration into the ACT-PI model. RESULTS: Perceived benefits of police integration were opportunities for relationship building between officers and clients, improved safety, more holistic care due to embeddedness (i.e., effective interagency collaboration between police and health care providers), the prevention of future problems, and police officers' authority enhancing compliance. Perceived drawbacks included risk for legal consequences, stigma from police interaction, escalating distress of clients, low officer availability, and the risk for changing the nature of ACT teams. CONCLUSIONS: Participants reported that the model of officer integration into ACT-PI teams may improve both client and staff well-being. In some communities, and with certain precautions, ACT-PI may be a viable model for ACT teams serving clients with and clients without a history of forensic involvement.

Cyber Dating Abuse Victimization: Links With Psychosocial Functioning.

It is well established that technology can be used to enact intimate partner violence (IPV). However, less is known about how cyber dating abuse (CDA) is associated with psychosocial functioning, especially when accounting for other forms of frequently co-occurring IPV victimization. The current study sought to determine the unique associations of CDA victimization when controlling for multiple forms of in-person IPV victimization. Two hundred seventy-eight men and women between 17 and 25 years of age (M = 20.5, SD = 1.9) who were currently in an intimate relationship for at least 3 months participated in this study. Participants completed questionnaires about their IPV and CDA victimization, as well as a range of indices of psychosocial well-being. Experiencing CDA victimization was related to increased alcohol use for both men and women, and increased fear of partner for women, even after controlling for in-person IPV. For depression, perceived stress, relationship satisfaction, quality of life, social support, and post-traumatic stress, CDA victimization did not predict levels above in-person IPV victimization. Although these results suggest some unique associations between CDA victimization and aspects of psychosocial well-being that require further attention, they also highlight that CDA often occurs within a broader pattern of abuse that includes in-person IPV. These results suggest that the need for prevention and treatment for relationships that involve in-person abuse is still most salient, and that a narrow focus on CDA may limit the utility of prevention and treatment efforts. Further work is needed to integrate research on in-person and CDA victimization, rather than to create a new field of research and practice based solely on CDA.

Loss of Anks6 leads to YAP deficiency and liver abnormalities.

ANKS6 is a ciliary protein that localizes to the proximal compartment of the primary cilium, where it regulates signaling. Mutations in the ANKS6 gene cause multiorgan ciliopathies in humans, which include laterality defects of the visceral organs, renal cysts as part of nephronophthisis and congenital hepatic fibrosis (CHF) in the liver. Although CHF together with liver ductal plate malformations are common features of several human ciliopathy syndromes, including nephronophthisis-related ciliopathies, the mechanism by which mutations in ciliary genes lead to bile duct developmental abnormalities is not understood. Here, we generated a knockout mouse model of Anks6 and show that ANKS6 function is required for bile duct morphogenesis and cholangiocyte differentiation. The loss of Anks6 causes ciliary abnormalities, ductal plate remodeling defects and periportal fibrosis in the liver. Our expression studies and biochemical analyses show that biliary abnormalities in Anks6-deficient livers result from the dysregulation of YAP transcriptional activity in the bile duct-lining epithelial cells. Mechanistically, our studies suggest, that ANKS6 antagonizes Hippo signaling in the liver during bile duct development by binding to Hippo pathway effector proteins YAP1, TAZ and TEAD4 and promoting their transcriptional activity. Together, this study reveals a novel function for ANKS6 in regulating Hippo signaling during organogenesis and provides mechanistic insights into the regulatory network controlling bile duct differentiation and morphogenesis during liver development.

Lateral biases in aesthetic and spatial location judgments: differences between tasks and native reading directions.

People exhibit consistent leftward spatial biases across a variety of tasks. However, individuals with a native reading direction other than left-to-right (LTR) show an attenuation of the leftward bias. The current study used procedurally similar tasks to examine spatial ability and aesthetic preferences in LTR and right-to-left (RTL) groups. In the spatial task participants viewed a centred rectangle partially occluded by an overlapping circle and estimated the centre of the circle with a single mouse click. In the aesthetic task participants used the mouse to control a "virtual flashlight" to light images of abstract paintings in the most aesthetically pleasing way. Contrary to predictions, smaller errors were made for circles on the right and estimations were progressively less accurate as circle size increased in the spatial task. On the aesthetic task, light placements of LTR participants were biased to the left and significantly different from the slightly rightward placements of RTL participants. As predicted, when completing the aesthetics task amounts of time scanning left or right visual space were different between groups. Findings support the theory that directional scanning biases attenuate leftward lateral biases and further, the nature of the visuospatial task may vary the strength of lateral bias.

Cardiac autonomic functioning and post-traumatic stress: A preliminary study in youth at-risk for PTSD.

The identification of robust, psychophysiological markers of trauma-related distress is critical for developing comprehensive, trauma-informed, mental health assessments for youth. Thus, the present study examined the clinical utility of cardiac autonomic balance (CAB) and cardiac autonomic regulation (CAR), two composite indices of the sympathetic and parasympathetic nervous system. We hypothesized that CAB/CAR would more reliably index post-traumatic stress (PTS) responses compared to measuring the parasympathetic (i.e., respiratory sinus arrhythmia; RSA) and sympathetic (i.e., pre-ejection period; PEP) nervous systems in isolation. Our sample was comprised of 88 diverse, low-income youth (40.9% African-American and 36.4% White; 60.5% girls; Mage = 12.05 years; SDage = 1.57) who are at increased risk for adversity-exposure. RSA and PEP were measured during a 5-minute baseline period and 5-minute parent-child conflict discussion task. Adolescent-caregiver dyads completed a clinician-administered measure of the youth's lifetime trauma-exposure and current PTS. CAB represented the difference between RSA and PEP, while CAR was the summation of RSA and PEP. Analyses revealed that sympathetically-oriented CAB reactivity uniquely (a) indexed PTS, especially in the context of elevated trauma, and (b) distinguished between those with and without PTSD. Findings highlight the translational promise of using physiological markers that account for the balance between the parasympathetic and sympathetic nervous system.

Emerging Adulthood and Prospective Depression: A Simultaneous Test of Cumulative Risk Theories.

Past research indicates that a history of depression and exposure to abuse and neglect represent some of the most robust predictors of depression in emerging adults. However, studies rarely test the additive or interactive risk associated with these distinct risk factors. In response, the present study explored how these three risk factors (prior depression, abuse, and neglect) synergistically predicted prospective depressive symptoms in a sample of 214 emerging adults (Mage = 21.4 years; SDage = 2.4; 78% females). Subtypes of maltreatment and lifetime history of depression were assessed through semi-structured interviews, and depressive symptoms were assessed annually for three years via self-report measures. The results indicated that for both males and females, a lifetime history of depression, abuse, and neglect-exposure uniquely conferred risk for elevated depressive symptoms. Furthermore, the interaction between neglect and prior depression forecasted increasing depressive symptoms, and a history of abuse also predicted increasing depressive symptoms, but only in females. These findings are contextualized within extant developmental psychopathology theories, and translational implications for trauma-informed depression prevention efforts are discussed.

Overestimation of self-reported driving exposure: Results from the SHRP2 Naturalistic Driving Study.

OBJECTIVES: The accuracy of self-reported driving exposure has questioned the validity of using self-reported mileage to inform research questions. Studies examining the accuracy of self-reported driving exposure compared to objective measures find low validity, with drivers overestimating and underestimating driving distance. The aims of the current study were to (1) examine the discrepancy between self-reported annual mileage and driving exposure the following year and (2) investigate whether these differences depended on age and annual mileage. METHODS: Two estimates of drivers' self-reported annual mileage collected during vehicle installation (obtained via prestudy questionnaires) and approximated annual mileage driven (based upon Global Positioning System data) were acquired from 3,323 participants who participated in the Strategic Highway Research Program 2 (SHRP2) Naturalistic Driving Study. RESULTS: A Wilcoxon signed rank test showed that there was a significant difference between self-reported and annual driving exposure during participation in SHRP 2, with the majority of self-reported responses overestimating annual mileage the following year, irrespective of whether an ordinal or ratio variable was examined. Over 15% of participants provided self-reported responses with over 100% deviation, which were exclusive to participants underestimating annual mileage. Further, deviations in reporting differed between participants who had low, medium, and high exposure, as well as between participants in different age groups. CONCLUSIONS: These findings indicate that although self-reported annual mileage is heavily relied on for research, such estimates of driving distance may be an overestimate of current or future mileage and can influence the validity of prior research that has utilized estimates of driving exposure.

Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis.

There is an abundance of literature reporting an association between shift work and cardiovascular disease (CVD). Few studies have examined early manifestation of CVD using advanced modern methodology. We established a group of 65 shift workers and 29 day workers (controls) in two industrial plants. For the shift workers, the shift schedule includes rotating shifts with day, evening and nightshifts, some day and nightshifts lasting for 12 h. The current paper describes cross-sectional data in a study running for three years. We collected background data by questionnaire and measured blood pressure, heart rate, lipids, glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP). We examined arterial stiffness (central blood pressure, augmentation pressure and index, and pulse wave velocity) by the use of SphygmoCor® (AtCor Medical Pty Ltd, Sydney, Australia) and the carotid arteries by ultrasound. We assessed VO2max by bicycle ergometry. We applied linear and logistic regression to evaluate associations between total number of years in shift work and cardiovascular outcome measures. The day workers were older and had more pronounced arterial stiffness compared to the shift workers. Number of years as a shift worker was associated with increased carotid intima media thickness (max IMT) (B = 0.015, p = 0.009) and an elevated CRP (B = 0.06, p = 0.03). Within the normal range for this age group, VO2max was 41 (9) ml/kg/min. Rotating shift work including day and night shifts lasting up to 12 h and evening shifts are associated with CVD-risk factors. This could imply an increased risk for coronary heart disease and stroke among these workers. Therefore, preventive measures should be considered for these groups of workers in order to prevent such diseases.

Coercive control during the transition to parenthood: An overlooked factor in intimate partner violence and family wellbeing?

A key criticism of research on intimate partner violence (IPV) is that a sole focus on physical or psychological acts of aggression fails to account for other forms of manipulative behavior that may have serious consequences for partner and family functioning. The current study examines coercive control, or behavior designed to constrain or compel an intimate partner in some way, in a longitudinal community sample of 98 heterosexual couples assessed in the third trimester of pregnancy as well as at 1 and 2 years postpartum. We found that the majority of couples reported at least some coercive controlling behavior during the transition to parenthood, that coercive control was highly bi-directional between partners, and that women were more likely than men to engage in coercive control before parenthood. Using multilevel actor-partner interdependence modeling, we found that women's coercive control predicted their own as well as men's perpetration of IPV across the transition to parenthood. Controlling for IPV perpetration by both partners, women's coercive control was longitudinally predictive of men's depression, harmful alcohol use, relationship dissatisfaction, poor co-parenting, low perceived parenting competence, and perceptions of toddler problem behavior. Men's coercive control was longitudinally predictive of women's relationship dissatisfaction and parenting stress, as well as women's perceptions of infant problem behavior. Men's coercive control was associated with their own use of ineffective parenting behavior. These findings suggest that coercive control is common in community samples during the transition to parenthood and that coercive control predicts lower early family functioning.

Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.

BACKGROUND & AIMS: Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver injury among different mouse models because of our inability to visualize the progression of liver injury in vivo in mice. We developed a method to visualize bile transport and blood-bile barrier (BBlB) integrity in live mice. METHODS: C57BL/6 mice were fed a choline-deficient, ethionine-supplemented (CDE) diet or a diet containing 0.1% 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) for up to 4 weeks to induce chronic liver injury. We used quantitative liver intravital microscopy (qLIM) for real-time assessment of bile transport and BBlB integrity in the intact livers of the live mice fed the CDE, DDC, or chow (control) diets. Liver tissues were collected from mice and analyzed by histology, immunohistochemistry, real-time polymerase chain reaction, and immunoblots. RESULTS: Mice with liver injury induced by a CDE or a DDC diet had breaches in the BBlB and impaired bile secretion, observed by qLIM compared with control mice. Impaired bile secretion was associated with reduced expression of several tight-junction proteins (claudins 3, 5, and 7) and bile transporters (NTCP, OATP1, BSEP, ABCG5, and ABCG8). A prolonged (2-week) CDE, but not DDC, diet led to re-expression of tight junction proteins and bile transporters, concomitant with the reestablishment of BBlB integrity and bile secretion. CONCLUSIONS: We used qLIM to study chronic liver injury, induced by a choline-deficient or DDC diet, in mice. Progression of chronic liver injury was accompanied by loss of bile transporters and tight junction proteins.