ABSTRACT
Antiarrhythmic therapy of patients with disturbed automatism of the sinus node and impaired atrioventricular conductance may be complicated by hemodynamically significant bradycardias and contraindications for implantation of a cardiac electrical stimulator This study aimed at estimating effect of antiarrhythmic therapy with allapinin on the function of sinus and atrioventricular nodes. It included 20 patients (mean age 37.5+-2.3 years) with disturbed cardiac rhythm and sinus node dysfunction treated with allapinin (37.5 - 50 mg/d per os). This therapy had well apparent antiarrhythmic effect manifest as improvement of supraventricular and ventricular ectopic activities in the absence of negative influence on the function of sinus and atrioventricular nodes.
Subject(s)
Aconitine/analogs & derivatives , Heart Conduction System/drug effects , Sick Sinus Syndrome/complications , Tachycardia, Paroxysmal , Ventricular Premature Complexes , Aconitine/administration & dosage , Aconitine/adverse effects , Adult , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/adverse effects , Bradycardia/chemically induced , Depression, Chemical , Dose-Response Relationship, Drug , Drug Monitoring , Electrocardiography, Ambulatory , Electrophysiologic Techniques, Cardiac , Female , Heart Conduction System/physiopathology , Heart Rate/drug effects , Humans , Male , Sick Sinus Syndrome/diagnosis , Sick Sinus Syndrome/physiopathology , Tachycardia, Paroxysmal/diagnosis , Tachycardia, Paroxysmal/drug therapy , Tachycardia, Paroxysmal/etiology , Tachycardia, Paroxysmal/physiopathology , Treatment Outcome , Ventricular Premature Complexes/diagnosis , Ventricular Premature Complexes/drug therapy , Ventricular Premature Complexes/etiology , Ventricular Premature Complexes/physiopathologyABSTRACT
The aim of the study was to examine effect of cardioversion (CV) on the subjective and objective status of patients with persistent atrial fibrillation (AF) receiving different therapy. The study included 4 groups of patients (n = 85). Group 1 (n = 30) were given standard treatment. In group 2 (n = 25), standard therapy was supplemented by i.v. injections of emoxipin (200 mg/day). Treatment of group 3 (n = 10) included mildronat (50 mg/day, i.v.), patients of group 4 (n = 20) were given riboxin (200 mg/day, i.v.). It was shown that the recovery of sinus rhythm improved the quality of life and parameters of cardiovascular function in all the treated patients.
Subject(s)
Atrial Fibrillation/psychology , Electric Countershock/methods , Quality of Life , Atrial Fibrillation/physiopathology , Atrial Fibrillation/therapy , Cardiovascular Agents/administration & dosage , Cardiovascular Agents/therapeutic use , Echocardiography, Doppler , Electrocardiography, Ambulatory , Female , Follow-Up Studies , Heart Rate/physiology , Humans , Injections, Intravenous , Inosine Diphosphate/administration & dosage , Inosine Diphosphate/therapeutic use , Male , Methylhydrazines/administration & dosage , Methylhydrazines/therapeutic use , Middle Aged , Stroke Volume/physiology , Treatment OutcomeABSTRACT
The influence of mexidol on the acute toxicity and electrophysiological effects of nibentan, propranolol, and verapamil was experimentally studied. It was found that mexidol potentiates the ability of propranolol and verapamil to inhibit automatism of the sinus node and suppresses the ability of all the three drugs to increase the refractory period of myocardium. It is suggested that these effects are related to the action of mexidol upon ion channels.
