[Blastomogenic action of heavy vanadium-rich petroleum and its processing products]. / Blastomogennoe deistvie tiazheloi vysokovanadievoi nefti i produktov ee pererabotki.

The contributors performed a study of the blastomogenic properties of the heavy high vanadium oil processed at different temperatures. Skin applications of the oil and oil products in hybrid mice induced skin tumours in 27.5 (48.7%), pregastric--6.4 (7.6%), genital--15.4 (21.1%) cases. It was established that high temperatures of oil sublimation increased the benzopyrene contents and the oil products' blastomogenic activity.

[Vanadium level in the urine of workers on a shift-work schedule during drilling of oil wells for high-vanadium petroleum]. / Soderzhanie vanadiia v moche rabotaiushchikh v vakhtovo-smennykh usloviiakh dobychi vysokovanadievoi nefty.

The study was designed to analyze vanadium content in urine samples of 87 workers engaged in the production of high-vanadium oil and 50 persons of the control group. Statistical data verified an elevated vanadium content in the urine of oil miners and especially of operators of the shop of oil and gas production. Urine concentration of vanadium grew along with the increase in the length of service.

[Benzo(a)pyrene content of grain and the products of its processing]. / O soderzhanii benz(a)pirena v zerne i produktakh ego pererabotki.

The content of benz(a)pyrene (BP) was studied in the grain, different sorts of flour and in talkan, a Kazakh national food product, prepared from fried grain. It was found that the grain contained 0.33 micrograms/kg of BP, flour--33-58% of that in the grain. The carcinogen content in flour varied with its kind: the highest BP concentration was detected in rye flour, the lowest--in high-quality wheat flour. In talkan, prepared from fried wheat, the content of BP was twice as much compared to the non-fried wheat, due to the intensity of frying. A man, who makes use of talkan during his life, may receive a significant amount of BP which can be conducive to raising the incidence of tumors of the digestive organs, especially of the esophagus.

[Benzo(a)pyrene content in tea]. / O soderzhanii benz(a)pirena v chae.

Six samples of different kinds and sorts of native tea and 103 samples of tea beverage were tested for the benz(a)pyrene (BP) content. The results of the study showed that the carcinogen content in native tea varied from 2.4 micrograms/kg (in mixed tea No 36) to 3.84 micrograms/kg (in the Georgean tea, sort 1). The BP content in the tea beverage depended on the technology of its production. The carcinogen presence and its content increase in a violated technology of tea production may be an important factor in the genesis of esophagus carcinoma.

[Inhibiting effect of hypoxia on the development of tumor-like formations in the fungus Fusarium bulbigenum var. blasticola]. / Ingibiruiushchee vliianie gipoksii na formirovanie opukholepodobnykh obrazovanii u griba Fusarium bulbigenum var. blasticola.

When cultivating Fusarium bulbigenum var. blasticola on the synthetic Rider media on the primary colonies tumour-like formations appear which are autonomous nondifferentiated cells. They display the resemblance with the real tumours in the following signs: differentiation, polymorphism, unlimited self-maintainance, aerobic glycolysis, etc. It is shown that under conditions of hypoxia, corresponding to the altitude of 2000-1000 m above sea-level the frequency of tumour-like formations decreases by 9-66% as compared to the cultivation conditions at pO2 of atmospheric air.

[Precancerous and cancerous lesions of the esophagus and forestomach in mice with skin exposure to a heavy catalytic gas oil]. / Predrakovye i rakovoe porazheniia pishchevoda i predzheludka u myshei pri nakozhnom vozdeistvii tiazhelym kataliticheskim gazoilem.

Painting with heavy catalytic gas oil was followed by skin tumor development in 97 (84.3%) mice: benign lesions--21 and carcinoma--76 cases. Pathologic changes in the upper part of the digestive tract were found in 55 out of 106 mice (51.9%): precancerous lesions (leukoplakia, dysplasia and papilloma) in 54 cases and cancer in one animal. Frequency of development of papilloma in the cardia was 27 times that in the esophagus. Multicentric growth was typical of precancerous lesions. Papilloma of the cardia was found in one control animal. Resorptive as well as direct action of gas oil seem to have been the causative factors of the development of precancerous and neoplastic lesions of the upper part of the gastrointestinal tract. The agent found its way into the digestive tract as animals licked each other in the course of the experiments.

[Carcinogenic effect of a heavy catalytic gas oil]. / Kantserogennoe deistvie tiazhelogo kataliticheskogo gazoilia.

The carcinogenic effect of treatment with heavy catalytic gasoil on the skin of 120 albino noninbred mice was studied. Skin tumors arose in 97 of 115 animals (84.3%) which survived until the appearance of the first papillomas. In 21 mice, tumors were benign while cancer developed in 76 animals. 116 visceral neoplasms were detected in 99 animals (93.4%). They were found in the upper part of digestive tract of 57, the hematopoietic and lymphatic tissues of 57 and in the lungs of two animals. The study established a high carcinogenicity of heavy catalytic gasoil matched by early appearance and multicentric growth of tumors as well as rapid generalization of the process.