ABSTRACT
A method for obliteration of the gallbladder, based on its mucoclasis with phenol preparations, was developed in experiments on unbred dogs. The safety of using preparations based on phenol for chemical demucosation of the gallbladder is demonstrated. The suggested method may serve as a prototype for the development of similar interventions in clinical practice in acute cholecystitis and cholelithiasis after endoscopic cholecystostomy and cholecystolithoextraction. The method was used in clinical practice in 3 patients with acute calculous cholecystitis and severe concomitant pathology and a high operative-anesthesiological risk.
Subject(s)
Cholecystitis/therapy , Cholecystostomy , Cholelithiasis/therapy , Gallbladder/drug effects , Lithotripsy , Phenols/therapeutic use , Acute Disease , Animals , Cholecystitis/complications , Cholelithiasis/complications , Combined Modality Therapy , Dogs , Gallbladder/pathology , Humans , Laparoscopy , Phenol , Phenols/pharmacology , Risk FactorsABSTRACT
The paper provides the results obtained in the course of the cooperative All-Union programme on multifactor prevention of coronary heart disease (CHD), which has been implemented over 3 years to examine the efficiency of preventive actions aimed at correcting the levels of CHD risk factors. The study was conducted in 6 centers of the country among a non-organized male population aged 40-59 years. The outcome of the preventive measures, largely nonpharmacological ones, made during 3 years suggests that the prevalence of the major CHD risk factors may be reduced in the population. The preventive actions are the most beneficial in arterial hypertension and smoking.
Subject(s)
Coronary Disease/prevention & control , Hypercholesterolemia/prevention & control , Hypertension/prevention & control , National Health Programs/organization & administration , Smoking Prevention , Adult , Coronary Disease/epidemiology , Coronary Disease/etiology , Humans , Hypercholesterolemia/complications , Hypercholesterolemia/epidemiology , Hypertension/complications , Hypertension/epidemiology , Male , Middle Aged , Multicenter Studies as Topic , Risk Factors , Smoking/adverse effects , Smoking/epidemiology , Time Factors , USSRABSTRACT
The program of multifactorial primary prophylaxis was carried out for 5 years among the non-organized male population aged 40-59 years. A possibility of the disease control was demonstrated in respect to such risk factors as arterial hypertension and tobacco-smoking. No substantial changes were discovered in the prevalence of hypercholesterolemia, overweight, low physical activity as well as in the lethality due to coronary heart disease or in the rate of new cases of myocardial infarction. In the group of patients suffering from coronary heart disease, measures aimed at multifactorial secondary prophylaxis promoted a significant reduction of the lethality due to that disease and of the rate of new cases of myocardial infarction since the third year of intervention.
Subject(s)
Coronary Disease/prevention & control , Adult , Coronary Disease/etiology , Exercise/physiology , Follow-Up Studies , Humans , Hypertension/complications , Male , Middle Aged , Obesity/complications , Prevalence , Risk Factors , Smoking/adverse effects , UzbekistanABSTRACT
During the implementation of active prophylactic measures of pharmacological and nonpharmacological nature in unorganized population for 2 yrs with respect to 5 CHD risk factors the authors observed a stable decrease in the percentage of persons with high arterial pressure (by 10%) and smoking (by 9.7%). Intense physical training decreased excess body mass resulting in a decrease in the mean level of arterial pressure, the level of cholesterol in the blood and an increase in physical working capacity.
